LIPID MAPS

LMPD ID

LMP007733

Gene ID

Species

Escherichia coli K-12 (E. coli)

Gene Name

ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein

Gene Symbol

Synonyms

ECK3181; JW3159; yrbC

Summary

The first 21 aa are predicted to be a Type I signal peptide. [More information is available at EcoGene: EG12798].

Orthologs

ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]
Refseq ID	NP_417659
Protein GI	16131082
UniProt ID	P0ADV7
Length	211
RefSeq Status	REVIEWED
MFKRLMMVALLVIAPLSAATAADQTNPYKLMDEAAQKTFDRLKNEQPQIRANPDYLRTIVDQELLPYVQVKYAGALVLGQYYKSATPAQREAYFAAFREYLKQAYGQALAMYHGQTYQIAPEQPLGDKTIVPIRVTIIDPNGRPPVRLDFQWRKNSQTGNWQAYDMIAEGVSMITTKQNEWGTLLRTKGIDGLTAQLKSISQQKITLEEKK

Entrez Gene ID

Gene Name

ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein

Gene Symbol

Species

Escherichia coli K-12

GO ID	Source	Type	Description
GO:0042597	IEA:UniProtKB-KW	C	periplasmic space
GO:0005543	IMP:EcoCyc	F	phospholipid binding
GO:0015914	IMP:EcoCyc	P	phospholipid transport

KEGG Pathway ID	Description
eco02010	ABC transporters
ko02010	ABC transporters
M00210	Phospholipid transport system
eco_M00210	Phospholipid transport system

Accession	Description
IPR023094	Tol_tolerance_alpha
IPR008869	Ttg2/MlaC

Gene Name

ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein

Protein Entry

MLAC_ECOLI

UniProt ID

Species

E. coli

Comment Type	Description
Disruption Phenotype	Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269\|PubMed:19383799}.
Function	Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. {ECO:0000269\|PubMed:19383799}.
Similarity	Belongs to the MlaC/ttg2D family. {ECO:0000305}.
Subcellular Location	Periplasm {ECO:0000305\|PubMed:19383799}.

Protein GI	Database	Accession	Length	Protein Name
16131082	RefSeq	NP_417659	211	ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

Reference	Database	Accession	Length	Protein Name
GI:16131082	GenBank	KHJ01631.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KHJ07262.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KHJ13774.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KHJ16505.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KHJ25763.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	gnl	IGS	211	ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein [Escherichia coli ER2796]

Reference	Database	Accession	Length	Protein Name
GI:16131082	GenBank	KFD77921.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KFH82158.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KFH84610.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	GenBank	KFH91955.1	211	ABC transporter substrate-binding protein [Escherichia coli]
GI:16131082	gnl	PRJNA200626	211	auxiliary component YrbC [Escherichia coli O157:H7 str. SS17]
GI:16131082	gnl	PRJNA253471	211	putative ABC transporter, auxiliary component YrbC [Escherichia coli O157:H7 str. EDL933]