Gene/Proteome Database (LMPD)
LMPD ID
LMP007737
Gene ID
Species
Escherichia coli K-12 (E. coli)
Gene Name
methylmalonyl-CoA mutase
Gene Symbol
Synonyms
ECK2913; JW2884; mcm; sbm; yliK
Summary
Part of a four gene operon encoding enzymes converting succinate to propionate. [More information is available at EcoGene: EG11444]. Methylmalonyl-CoA mutase (MCM) catalyzes the reversible, stereospecific interconversion of methylmalonyl-CoA to succinyl-CoA . [More information is available at EcoCyc: EG11444].
Orthologs
Proteins
| methylmalonyl-CoA mutase [Escherichia coli str. K-12 substr. MG1655] | |
|---|---|
| Refseq ID | NP_417392 |
| Protein GI | 16130818 |
| UniProt ID | P27253 |
| Length | 714 |
| RefSeq Status | REVIEWED |
| MSNVQEWQQLANKELSRREKTVDSLVHQTAEGIAIKPLYTEADLDNLEVTGTLPGLPPYVRGPRATMYTAQPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNPRVAGDVGKAGVAIDTVEDMKVLFDQIPLDKMSVSMTMNGAVLPVLAFYIVAAEEQGVTPDKLTGTIQNDILKEYLCRNTYIYPPKPSMRIIADIIAWCSGNMPRFNTISISGYHMGEAGANCVQQVAFTLADGIEYIKAAISAGLKIDDFAPRLSFFFGIGMDLFMNVAMLRAARYLWSEAVSGFGAQDPKSLALRTHCQTSGWSLTEQDPYNNVIRTTIEALAATLGGTQSLHTNAFDEALGLPTDFSARIARNTQIIIQEESELCRTVDPLAGSYYIESLTDQIVKQARAIIQQIDEAGGMAKAIEAGLPKRMIEEASAREQSLIDQGKRVIVGVNKYKLDHEDETDVLEIDNVMVRNEQIASLERIRATRDDAAVTAALNALTHAAQHNENLLAAAVNAARVRATLGEISDALEVAFDRYLVPSQCVTGVIAQSYHQSEKSASEFDAIVAQTEQFLADNGRRPRILIAKMGQDGHDRGAKVIASAYSDLGFDVDLSPMFSTPEEIARLAVENDVHVVGASSLAAGHKTLIPELVEALKKWGREDICVVAGGVIPPQDYAFLQERGVAAIYGPGTPMLDSVRDVLNLISQHHD | |
Gene Information
Entrez Gene ID
Gene Name
methylmalonyl-CoA mutase
Gene Symbol
Species
Escherichia coli K-12
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031419 | IDA:EcoCyc | F | cobalamin binding |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004494 | IDA:EcoCyc | F | methylmalonyl-CoA mutase activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| eco01200 | Carbon metabolism |
| ko01200 | Carbon metabolism |
| eco00630 | Glyoxylate and dicarboxylate metabolism |
| ko00630 | Glyoxylate and dicarboxylate metabolism |
| eco01100 | Metabolic pathways |
| eco01120 | Microbial metabolism in diverse environments |
| eco00640 | Propanoate metabolism |
| ko00640 | Propanoate metabolism |
| eco00280 | Valine, leucine and isoleucine degradation |
| ko00280 | Valine, leucine and isoleucine degradation |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY0-43 | conversion of succinate to propionate |
| PWY0-43 | conversion of succinate to propionate |
| PWY0-43 | conversion of succinate to propionate |
| PWY-5088 | glutamate degradation VIII (to propionate) |
| PROPIONMET-PWY | propionyl CoA degradation |
| PROPIONMET-PWY | propionyl CoA degradation |
| P108-PWY | pyruvate fermentation to propionate I |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006158 | Cobalamin (vitamin B12)-binding domain |
| IPR016176 | Cobalamin (vitamin B12)-dependent enzyme, catalytic |
| IPR014348 | Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain |
| IPR006159 | Methylmalonyl-CoA mutase, C-terminal |
| IPR006098 | Methylmalonyl-CoA mutase, alpha chain, catalytic |
| IPR006099 | Methylmalonyl-CoA mutase, alpha/beta chain, catalytic |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (R)-methylmalonyl-CoA = succinyl-CoA. {ECO:0000269|PubMed:10769117, ECO:0000269|PubMed:11955068}. |
| Cofactor | Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408; Evidence={ECO:0000269|PubMed:10769117, ECO:0000269|PubMed:11955068}; |
| Function | Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA. Could be part of a pathway that converts succinate to propionate. {ECO:0000269|PubMed:10769117, ECO:0000269|PubMed:11955068}. |
| Similarity | Belongs to the methylmalonyl-CoA mutase family. {ECO:0000305}. |
| Similarity | Contains 1 B12-binding domain. {ECO:0000255|PROSITE- ProRule:PRU00666}. |
| Subunit | Homodimer. Interacts with ArgK. {ECO:0000269|PubMed:18950999}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007737 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16130818 | RefSeq | NP_417392 | 714 | methylmalonyl-CoA mutase [Escherichia coli str. K-12 substr. MG1655] |
Identical Sequences to LMP007737 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130818 | GenBank | KHI14498.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |
| GI:16130818 | GenBank | KHI16091.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |
| GI:16130818 | GenBank | KHI24241.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |
| GI:16130818 | GenBank | KHI62540.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |
| GI:16130818 | GenBank | KHI94656.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |
| GI:16130818 | gnl | IGS | 714 | methylmalonyl-CoA mutase [Escherichia coli ER2796] |
Related Sequences to LMP007737 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130818 | GenBank | EGX04620.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli G58-1] |
| GI:16130818 | GenBank | EQS92499.1 | 714 | protein sbm [Escherichia coli HVH 164 (4-5953081)] |
| GI:16130818 | GenBank | ERB18560.1 | 714 | protein sbm [Escherichia coli UMEA 3151-1] |
| GI:16130818 | RefSeq | WP_000073222.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |
| GI:16130818 | RefSeq | WP_021536837.1 | 714 | protein sbm [Escherichia coli] |
| GI:16130818 | RefSeq | WP_033550288.1 | 714 | methylmalonyl-CoA mutase [Escherichia coli] |