Gene/Proteome Database (LMPD)
LMPD ID
LMP007749
Gene ID
Species
Escherichia coli K-12 (E. coli)
Gene Name
undecaprenyl phosphate-L-Ara4FN transferase
Gene Symbol
Synonyms
ECK2247; JW2248; ORF2; pmrF; yfbF
Summary
Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. [More information is available at EcoGene: EG14090]. ArnC is an undecaprenyl transferase that acts in a pathway which modifies lipid A phosphates with 4-amino-4-deoxy-L-arabinose (L-Ara4N), causing increased resistance to polymyxin . [More information is available at EcoCyc: G7167].
Orthologs
Proteins
| undecaprenyl phosphate-L-Ara4FN transferase [Escherichia coli str. K-12 substr. MG1655] | |
|---|---|
| Refseq ID | NP_416757 |
| Protein GI | 16130189 |
| UniProt ID | P77757 |
| Length | 322 |
| RefSeq Status | REVIEWED |
| MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE | |
Gene Information
Entrez Gene ID
Gene Name
undecaprenyl phosphate-L-Ara4FN transferase
Gene Symbol
Species
Escherichia coli K-12
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:EcoCyc | C | membrane |
| GO:0005886 | IEA:UniProtKB-HAMAP | C | plasma membrane |
| GO:0016780 | IDA:EcoCyc | F | phosphotransferase activity, for other substituted phosphate groups |
| GO:0016757 | IEA:UniProtKB-KW | F | transferase activity, transferring glycosyl groups |
| GO:0036108 | IEA:UniProtKB-UniPathway | P | 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process |
| GO:0009245 | IEA:UniProtKB-HAMAP | P | lipid A biosynthetic process |
| GO:0009103 | IEA:UniProtKB-UniPathway | P | lipopolysaccharide biosynthetic process |
| GO:0046677 | IEA:UniProtKB-KW | P | response to antibiotic |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| eco00520 | Amino sugar and nucleotide sugar metabolism |
| ko00520 | Amino sugar and nucleotide sugar metabolism |
| eco01110 | Biosynthesis of secondary metabolites |
BIOCYC Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
undecaprenyl phosphate-L-Ara4FN transferase
Protein Entry
ARNC_ECOLI
UniProt ID
Species
E. coli
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | UDP-4-deoxy-4-formamido-beta-L-arabinose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4- formamido-alpha-L-arabinose ditrans,octacis-undecaprenyl phosphate. {ECO:0000269|PubMed:15695810}. |
| Function | Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. {ECO:0000269|PubMed:11706007}. |
| Induction | Induced by BasR. {ECO:0000250}. |
| Pathway | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000269|PubMed:17928292}. |
| Pathway | Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L- arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy- alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4- formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2. {ECO:0000269|PubMed:17928292}. |
| Similarity | Belongs to the glycosyltransferase 2 family. {ECO:0000305}. |
| Subcellular Location | Cell inner membrane; Multi-pass membrane protein. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007749 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16130189 | RefSeq | NP_416757 | 322 | undecaprenyl phosphate-L-Ara4FN transferase [Escherichia coli str. K-12 substr. MG1655] |
Identical Sequences to LMP007749 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130189 | GenBank | KHI74504.1 | 322 | UDP phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli] |
| GI:16130189 | GenBank | KHI82387.1 | 322 | UDP phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli] |
| GI:16130189 | GenBank | KHI92638.1 | 322 | UDP phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli] |
| GI:16130189 | GenBank | KHJ14693.1 | 322 | UDP phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli] |
| GI:16130189 | GenBank | KHJ24267.1 | 322 | UDP phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli] |
| GI:16130189 | gnl | IGS | 322 | undecaprenyl phosphate-L-Ara4FN transferase [Escherichia coli ER2796] |
Related Sequences to LMP007749 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16130189 | GenBank | EMW34552.1 | 322 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli 2785200] |
| GI:16130189 | GenBank | EMW60669.1 | 322 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli 2756500] |
| GI:16130189 | GenBank | ENF83446.1 | 322 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli P0305260.11] |
| GI:16130189 | GenBank | ENG42258.1 | 322 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli p0305293.11] |
| GI:16130189 | GenBank | ENG71164.1 | 322 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli p0305293.8] |
| GI:16130189 | RefSeq | WP_001638148.1 | 322 | undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli] |