Gene/Proteome Database (LMPD)

LMPD ID
LMP007761
Gene ID
947026
Species
Escherichia coli K-12 (E. coli)
Gene Name
phosphatidylglycerophosphatase C, membrane bound
Gene Symbol
pgpC
Synonyms
ECK2558; JW5408; yfhB
Summary
None
Orthologs
View orthologs and multiple alignments for pgpC

Proteins

phosphatidylglycerophosphatase C, membrane bound [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417055
Protein GI 90111459
UniProt ID P0AD42
Length 211
RefSeq Status REVIEWED
MATHERRVVFFDLDGTLHQQDMFGSFLRYLLRRQPLNALLVLPLLPIIAIALLIKGRAARWPMSLLLWGCTFGHSEARLQTLQADFVRWFRDNVTAFPLVQERLTTYLLSSDADIWLITGSPQPLVEAVYFDTPWLPRVNLIASQIQRGYGGWVLTMRCLGHEKVAQLERKIGTPLRLYSGYSDSNQDNPLLYFCQHRWRVTPRGELQQLE

Gene Information

Entrez Gene ID
947026
Gene Name
phosphatidylglycerophosphatase C, membrane bound
Gene Symbol
pgpC
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 IDA:EcoCyc C integral component of plasma membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0008962 IMP:EcoCyc F phosphatidylglycerophosphatase activity
GO:0016311 IMP:GOC P dephosphorylation
GO:0046474 IMP:EcoCyc P glycerophospholipid biosynthetic process
GO:0006655 IEA:UniProtKB-UniPathway P phosphatidylglycerol biosynthetic process
GO:0009395 IEA:UniProtKB-KW P phospholipid catabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5668 cardiolipin biosynthesis I
PWY-5668 cardiolipin biosynthesis I
PWY0-1545 cardiolipin biosynthesis III
PWY0-1545 cardiolipin biosynthesis III
PHOSLIPSYN-PWY phospholipid biosynthesis I
PHOSLIPSYN-PWY phospholipid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR006435 HAD-SF_hydro_IF_YfhB
IPR023214 HAD-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylglycerophosphatase C, membrane bound
Protein Entry
PGPC_ECOLI
UniProt ID
P0AD42
Species
E. coli

Comments

Comment Type Description
Catalytic Activity Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. {ECO:0000269|PubMed:21148555}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:21148555};
Disruption Phenotype No visible phenotype. Simultaneous deletion of pgpC and pgpA increases phosphatidylglycerophosphate (PGP) levels almost hundredfold relative to wild-type. In constrast, simultaneous deletion of pgpC and pgpB leads to a twofold increase of PGP levels. Lethal when combined with deletion of both pgpA and pgpB. {ECO:0000269|PubMed:21148555}.
Function Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). {ECO:0000269|PubMed:21148555}.
Pathway Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
Sequence Caution Sequence=AAA79822.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA10910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA51063.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Subcellular Location Cell inner membrane {ECO:0000269|PubMed:21148555}; Single-pass membrane protein {ECO:0000269|PubMed:21148555}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007761 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90111459 RefSeq NP_417055 211 phosphatidylglycerophosphatase C, membrane bound [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007761 proteins

Reference Database Accession Length Protein Name
GI:90111459 GenBank KHJ01126.1 211 hypothetical protein PU11_11035 [Escherichia coli]
GI:90111459 GenBank KHJ09762.1 211 hypothetical protein PU08_00835 [Escherichia coli]
GI:90111459 GenBank KHJ14098.1 211 hypothetical protein PU10_06925 [Escherichia coli]
GI:90111459 GenBank KHJ21487.1 211 hypothetical protein PU06_05450 [Escherichia coli]
GI:90111459 GenBank KHJ27203.1 211 hypothetical protein PU03_05800 [Escherichia coli]
GI:90111459 gnl IGS 211 hypothetical protein ER2796_2642 [Escherichia coli ER2796]

Related Sequences to LMP007761 proteins

Reference Database Accession Length Protein Name
GI:90111459 GenBank EFW74713.1 211 hypothetical protein ECoL_02962 [Escherichia coli EC4100B]
GI:90111459 GenBank EGK21916.1 211 hypothetical protein SFK272_3349 [Shigella flexneri K-272]
GI:90111459 GenBank EGK35506.1 211 hypothetical protein SFK227_3185 [Shigella flexneri K-227]
GI:90111459 GenBank KHJ21998.1 211 hypothetical protein PU04_18295 [Escherichia coli]
GI:90111459 RefSeq WP_000190652.1 211 hypothetical protein [Escherichia coli]
GI:90111459 RefSeq WP_005076349.1 211 MULTISPECIES: hypothetical protein [Enterobacteriaceae]