Gene/Proteome Database (LMPD)

LMPD ID
LMP007767
Gene ID
947315
Species
Escherichia coli K-12 (E. coli)
Gene Name
fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase
Gene Symbol
aas
Synonyms
ECK2832; JW2804
Summary
The protein contains bound ACP. [More information is available at EcoCyc: EG11679].
Orthologs
View orthologs and multiple alignments for aas

Proteins

fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase [Escherichia coli str. K-12 substr. MG1655]
Refseq ID NP_417313
Protein GI 16130740
UniProt ID P31119
Length 719
RefSeq Status REVIEWED
MLFSFFRNLCRVLYRVRVTGDTQALKGERVLITPNHVSFIDGILLGLFLPVRPVFAVYTSISQQWYMRWLKSFIDFVPLDPTQPMAIKHLVRLVEQGRPVVIFPEGRITTTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSRLKGLVKRRLFPQITLHILPPTQVAMPDAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLSAMYRFGAGKKCVEDVNFTPDSYRKLLTKTLFVGRILEKYSVEGERIGLMLPNAGISAAVIFGAIARRRMPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTTADKVWIFAHLLMPRLAQVKQQPEEEALILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTTNDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRSCTVLFGTSTFLGHYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLSVPGIEEGGRLQLKGPNIMNGYLRVEKPGVLEVPTAENVRGEMERGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKVHATAIKSDASKGEALVLFTTDNELTRDKLQQYAREHGVPELAVPRDIRYLKQMPLLGSGKPDFVTLKSWVDEAEQHDE

Gene Information

Entrez Gene ID
947315
Gene Name
fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase
Gene Symbol
aas
Species
Escherichia coli K-12

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:EcoliWiki C integral component of membrane
GO:0005886 IEA:UniProtKB-HAMAP C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008779 IDA:EcoliWiki F acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
GO:0008922 IDA:EcoliWiki F long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0006631 IGI:EcoliWiki P fatty acid metabolic process
GO:0008654 IGI:EcoliWiki P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
eco00071 Fatty acid degradation
ko00071 Fatty acid degradation
eco00564 Glycerophospholipid metabolism
ko00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR023775 Bifunctional_Aas
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase
Protein Entry
AAS_ECOLI
UniProt ID
P31119
Species
E. coli

Comments

Comment Type Description
Catalytic Activity ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein]. {ECO:0000255|HAMAP- Rule:MF_01162}.
Catalytic Activity Acyl-[acyl-carrier-protein] + O-(2-acyl-sn- glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1- beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. {ECO:0000255|HAMAP-Rule:MF_01162}.
Function Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1. {ECO:0000255|HAMAP-Rule:MF_01162, ECO:0000269|PubMed:1649829}.
Similarity In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family. {ECO:0000255|HAMAP- Rule:MF_01162}.
Similarity In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family. {ECO:0000255|HAMAP-Rule:MF_01162}.
Subcellular Location Cell inner membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007767 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16130740 RefSeq NP_417313 719 fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase [Escherichia coli str. K-12 substr. MG1655]

Identical Sequences to LMP007767 proteins

Reference Database Accession Length Protein Name
GI:16130740 GenBank KHH95558.1 719 acyl-ACP synthetase [Escherichia coli]
GI:16130740 GenBank KHI18345.1 719 acyl-ACP synthetase [Escherichia coli]
GI:16130740 GenBank KHI20352.1 719 acyl-ACP synthetase [Escherichia coli]
GI:16130740 GenBank KHI58877.1 719 acyl-ACP synthetase [Escherichia coli]
GI:16130740 GenBank KHJ23346.1 719 acyl-ACP synthetase [Escherichia coli]
GI:16130740 gnl IGS 719 fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase [Escherichia coli ER2796]

Related Sequences to LMP007767 proteins

Reference Database Accession Length Protein Name
GI:16130740 EMBL CDP77799.1 719 Putative uncharacterized protein [Escherichia coli D6-117.29]
GI:16130740 GenBank EYE11643.1 719 bifunctional protein aas [Escherichia coli 1-110-08_S3_C3]
GI:16130740 GenBank EYE19703.1 719 bifunctional protein aas [Escherichia coli 1-110-08_S3_C2]
GI:16130740 GenBank KDU39149.1 719 bifunctional protein aas [Escherichia coli 3-073-06_S4_C1]
GI:16130740 RefSeq WP_000899055.1 719 2-acyl-glycerophospho-ethanolamine acyltransferase [Escherichia coli]
GI:16130740 RefSeq WP_032230146.1 719 acyl-ACP synthetase [Escherichia coli]