Gene/Proteome Database (LMPD)
LMPD ID
LMP007781
Gene ID
Species
Escherichia coli K-12 (E. coli)
Gene Name
3-oxoacyl-[acyl-carrier-protein] synthase III
Gene Symbol
Synonyms
ECK1077; JW1077
Summary
fabH is an essential gene. [More information is available at EcoGene: EG10277]. There are three -ketoacyl-ACP synthases (KAS) in Escherichia coli: |FRAME: [More information is available at EcoCyc: EG10277].
Orthologs
Proteins
| 3-oxoacyl-[acyl-carrier-protein] synthase III [Escherichia coli str. K-12 substr. MG1655] | |
|---|---|
| Refseq ID | NP_415609 |
| Protein GI | 16129054 |
| UniProt ID | P0A6R0 |
| Length | 317 |
| RefSeq Status | REVIEWED |
| MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF | |
Gene Information
Entrez Gene ID
Gene Name
3-oxoacyl-[acyl-carrier-protein] synthase III
Gene Symbol
Species
Escherichia coli K-12
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-HAMAP | C | cytoplasm |
| GO:0004315 | IEA:InterPro | F | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| GO:0033818 | IDA:EcoCyc | F | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| GO:0006633 | IEA:UniProtKB-HAMAP | P | fatty acid biosynthetic process |
| GO:0006631 | IMP:CACAO | P | fatty acid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| eco00061 | Fatty acid biosynthesis |
| ko00061 | Fatty acid biosynthesis |
| M00083 | Fatty acid biosynthesis, elongation |
| eco_M00083 | Fatty acid biosynthesis, elongation |
| M00082 | Fatty acid biosynthesis, initiation |
| eco_M00082 | Fatty acid biosynthesis, initiation |
| eco01212 | Fatty acid metabolism |
| ko01212 | Fatty acid metabolism |
| eco01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6519 | 7-keto-8-aminopelargonate biosynthesis I |
| BIOTIN-BIOSYNTHESIS-PWY | biotin biosynthesis I |
| PWY-4381 | fatty acid biosynthesis initiation I |
| PWY-4381 | fatty acid biosynthesis initiation I |
| PWY-4381 | fatty acid biosynthesis initiation I |
| PWY-5966 | fatty acid biosynthesis initiation II |
| PWY-5966 | fatty acid biosynthesis initiation II |
| PWY-5966 | fatty acid biosynthesis initiation II |
| FASYN-ELONG-PWY | fatty acid elongation -- saturated |
| PWY0-881 | superpathway of fatty acid biosynthesis I (E. coli) |
| PWY0-881 | superpathway of fatty acid biosynthesis I (E. coli) |
| FASYN-INITIAL-PWY | superpathway of fatty acid biosynthesis initiation (E. coli) |
| FASYN-INITIAL-PWY | superpathway of fatty acid biosynthesis initiation (E. coli) |
| FASYN-INITIAL-PWY | superpathway of fatty acid biosynthesis initiation (E. coli) |
| PWY-6285 | superpathway of fatty acids biosynthesis (E. coli) |
Domain Information
UniProt Annotations
Entry Information
Gene Name
3-oxoacyl-[acyl-carrier-protein] synthase III
Protein Entry
FABH_ECOLI
UniProt ID
Species
E. coli
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2). |
| Domain | The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. {ECO:0000269|PubMed:11078736}. |
| Enzyme Regulation | Negatively regulated by acyl-ACP, possibly by binding to either the free enzyme or the acyl-enzyme intermediate. {ECO:0000269|PubMed:8631920}. |
| Function | Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain. |
| Miscellaneous | Inhibited by the SB418011 antibiotic. Not inhibited by cerulenin and thiolactomycin. |
| Pathway | Lipid metabolism; fatty acid biosynthesis. |
| Similarity | Belongs to the FabH family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm. |
| Subunit | Homodimer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007781 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 16129054 | RefSeq | NP_415609 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase III [Escherichia coli str. K-12 substr. MG1655] |
Identical Sequences to LMP007781 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16129054 | GenBank | KHJ03799.1 | 317 | 3-oxoacyl-ACP synthase [Escherichia coli] |
| GI:16129054 | GenBank | KHJ05626.1 | 317 | 3-oxoacyl-ACP synthase [Escherichia coli] |
| GI:16129054 | GenBank | KHJ17518.1 | 317 | 3-oxoacyl-ACP synthase [Escherichia coli] |
| GI:16129054 | GenBank | KHJ22770.1 | 317 | 3-oxoacyl-ACP synthase [Escherichia coli] |
| GI:16129054 | GenBank | KHJ27491.1 | 317 | 3-oxoacyl-ACP synthase [Escherichia coli] |
| GI:16129054 | gnl | IGS | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase III [Escherichia coli ER2796] |
Related Sequences to LMP007781 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:16129054 | GenBank | EOQ76225.1 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 [Escherichia coli KTE33] |
| GI:16129054 | GenBank | EOU44437.1 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 [Escherichia sp. KTE114] |
| GI:16129054 | GenBank | EOV65094.1 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 [Escherichia coli KTE69] |
| GI:16129054 | GenBank | EOV73894.1 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 [Escherichia coli KTE70] |
| GI:16129054 | RefSeq | WP_016240891.1 | 317 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 [Escherichia coli] |
| GI:16129054 | RefSeq | WP_024239750.1 | 317 | 3-oxoacyl-ACP synthase [Escherichia coli] |