Gene/Proteome Database (LMPD)

LMPD ID
LMP007786
Gene ID
176047
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein HMGR-1
Gene Symbol
hmgr-1
Synonyms
CELE_F08F8.2
Chromosome
III

Proteins

Protein HMGR-1
Refseq ID NP_498626
Protein GI 25144592
UniProt ID Q19207
mRNA ID NM_066225
Length 550
RefSeq Status REVIEWED
MVADKRKLLDFLQSCDISDEASRKIENFICENYDQKEKPKRKPLFSVGEDDDSEEYVSPIKETCETGTQCKRDVEYPEIESGNRSLDEISREWKECKDVTPGEAVRLLRRGQAKSRELESRFPAEQAIPIRRTFINKKFENLPYLGYDYTLATECCCENVIGYTPVPVGVAGPLTLNGTSEIYVPMATTEGALIASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPENQDRARQEFQSCSRFAKLKSIDITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLMENFPEMTVLALSGNLCVDKKAAAKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGSSRAGAVGGSNAHAANIVAAIFIATGQDAAQVVSSSMCSTRMEVTADKNLYVSCTLPCVEVGTVGGGTILAPQRACLESLGCAGPNKEQPGQNAERLAEVIAATVLAGELSLMAALTTNELVSSHMKLNRSKQQLYADDSGKATHFEKEVEKAGSLLSGKSGNIKLKRLPQDVVQCSNIL

Gene Information

Entrez Gene ID
176047
Gene Name
Protein HMGR-1
Gene Symbol
hmgr-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:InterPro C integral component of membrane
GO:0004420 IEA:UniProtKB-EC F hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0050661 IEA:InterPro F NADP binding
GO:0015936 IEA:InterPro P coenzyme A metabolic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal

UniProt Annotations

Entry Information

Gene Name
Protein HMGR-1
Protein Entry
Q19207_CAEEL
UniProt ID
Q19207
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity (R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
Similarity Belongs to the HMG-CoA reductase family.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP007786 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25144592 RefSeq NP_498626 550 Protein HMGR-1

Identical Sequences to LMP007786 proteins

Reference Database Accession Length Protein Name
GI:25144592 EMBL CCD69058.1 550 Protein HMGR-1 [Caenorhabditis elegans]

Related Sequences to LMP007786 proteins

Reference Database Accession Length Protein Name
GI:25144592 EMBL CAP33633.1 555 Protein CBG15296 [Caenorhabditis briggsae]
GI:25144592 EMBL CDJ81121.1 578 Hydroxymethylglutaryl-CoA reductase domain containing protein [Haemonchus contortus]
GI:25144592 GenBank EFO97551.1 555 hypothetical protein CRE_12323 [Caenorhabditis remanei]
GI:25144592 GenBank EGT36682.1 551 hypothetical protein CAEBREN_19887 [Caenorhabditis brenneri]
GI:25144592 RefSeq XP_002643123.1 555 Hypothetical protein CBG15296 [Caenorhabditis briggsae]
GI:25144592 RefSeq XP_003092294.1 555 hypothetical protein CRE_12323 [Caenorhabditis remanei]