Gene/Proteome Database (LMPD)

LMPD ID
LMP007788
Gene ID
175339
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein MBOA-6
Gene Symbol
mboa-6
Synonyms
CELE_R155.1
Alternate Names
Protein MBOA-6
Chromosome
III
EC Number
2.3.1.-

Proteins

Protein MBOA-6, isoform a
Refseq ID NP_001022735
Protein GI 71989981
UniProt ID O01925
mRNA ID NM_001027564
Length 473
RefSeq Status REVIEWED
MGVVGALSEVTSASEDALRLLISVLAGYPLAVVHRTFFYNKPAQHQHLFFVIVGLSLWMFNCGSSVIHPILSIFGAFFITNFMAGTDASIYAAHIVFLGHLLIGYWFHETDTYDITWTTPFCIMTLRFIGLVMDVYDGAQKPEHLKPDQKLTAISDKPGLLEIAAFGLFFQGTLVGPQFTLSKFRSFVNGDWLDSDGQPPKSAFLPSIGRFLAGCTYMVLHQWGQFWIPDQYFNSDAYNNLSFFWRWSWVTLWFRLTMYKYCAMWLITEGASILSGLGHNGKDAEGNDRWDGVRDLHIIKWETGHDYNSVVESFNCGTNTFAKNHIHRRLRWVNNKLASHVITLSYLAIWHGYHLGYFLLFGVELGCVQAQNQLYALIKRTPGWSEAISKPISRPFIWIFGKLTISYSMGFAFLMFGLIKTKYWIGPVKSLYFIGFIIYFIVWPILHMVLLRVLPRHPKKAAAEKPEEVKKEL
Protein MBOA-6, isoform b
Refseq ID NP_001022736
Protein GI 71989986
UniProt ID O01925
mRNA ID NM_001027565
Length 341
RefSeq Status REVIEWED
MDVYDGAQKPEHLKPDQKLTAISDKPGLLEIAAFGLFFQGTLVGPQFTLSKFRSFVNGDWLDSDGQPPKSAFLPSIGRFLAGCTYMVLHQWGQFWIPDQYFNSDAYNNLSFFWRWSWVTLWFRLTMYKYCAMWLITEGASILSGLGHNGKDAEGNDRWDGVRDLHIIKWETGHDYNSVVESFNCGTNTFAKNHIHRRLRWVNNKLASHVITLSYLAIWHGYHLGYFLLFGVELGCVQAQNQLYALIKRTPGWSEAISKPISRPFIWIFGKLTISYSMGFAFLMFGLIKTKYWIGPVKSLYFIGFIIYFIVWPILHMVLLRVLPRHPKKAAAEKPEEVKKEL

Gene Information

Entrez Gene ID
175339
Gene Name
Protein MBOA-6
Gene Symbol
mboa-6
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 ISS:WormBase C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047184 IEA:UniProtKB-EC F 1-acylglycerophosphocholine O-acyltransferase activity
GO:0008374 ISS:WormBase F O-acyltransferase activity
GO:0002119 IMP:WormBase P nematode larval development
GO:0006656 IMP:WormBase P phosphatidylcholine biosynthetic process
GO:0006646 IMP:WormBase P phosphatidylethanolamine biosynthetic process
GO:0006659 IMP:WormBase P phosphatidylserine biosynthetic process
GO:0040010 IMP:WormBase P positive regulation of growth rate
GO:0040032 IMP:WormBase P post-embryonic body morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
cel00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5653397 Acyl chain remodelling of PC
5653402 Acyl chain remodelling of PE
5653401 Acyl chain remodelling of PS

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT

UniProt Annotations

Entry Information

Gene Name
Protein MBOA-6
Protein Entry
MBOA5_CAEEL
UniProt ID
O01925
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=a; IsoId=O01925-1; Sequence=Displayed; Name=b; IsoId=O01925-2; Sequence=VSP_053557;
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. {ECO:0000269|PubMed:18782225}.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:18782225}.
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. {ECO:0000269|PubMed:18782225}.
Domain The di-lysine motif may confer endoplasmic reticulum localization. {ECO:0000250}.
Function Probable acyltransferase which may mediate the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn- glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2- hydroxy-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Required for incorporation of arachidonic acid into PC, PE, and PS. {ECO:0000269|PubMed:18782225}.
Pathway Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:18782225}.
Similarity Belongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007788 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71989981 RefSeq NP_001022735 473 Protein MBOA-6, isoform a
71989986 RefSeq NP_001022736 341 Protein MBOA-6, isoform b

Identical Sequences to LMP007788 proteins

Reference Database Accession Length Protein Name
GI:71989981 EMBL CCD71668.1 473 Protein MBOA-6, isoform a [Caenorhabditis elegans]
GI:71989986 EMBL CCD71669.1 341 Protein MBOA-6, isoform b [Caenorhabditis elegans]
GI:71989981 SwissProt O01925.2 473 RecName: Full=Lysophospholipid acyltransferase 5; Short=LPLAT 5; AltName: Full=Probable 1-acylglycerophosphocholine O-acyltransferase; AltName: Full=Probable 1-acylglycerophosphoethanolamine O-acyltransferase; AltName: Full=Probable 1-acylglycerophosphoserine O-acyltransferase; AltName: Full=Probable lysophosphatidylcholine acyltransferase; Short=LPCAT; Short=Lyso-PC acyltransferase; AltName: Full=Probable lysophosphatidylethanolamine acyltransferase; Short=LPEAT; Short=Lyso-PE acyltransferase; AltName: Full=Probable lysophosphatidylserine acyltransferase; Short=LPSAT; Short=Lyso-PS acyltransferase [Caenorhabditis elegans]

Related Sequences to LMP007788 proteins

Reference Database Accession Length Protein Name
GI:71989981 EMBL CAP30839.2 475 Protein CBG11740 [Caenorhabditis briggsae]
GI:71989986 EMBL CCD71668.1 473 Protein MBOA-6, isoform a [Caenorhabditis elegans]
GI:71989981 GenBank EFP06159.1 474 hypothetical protein CRE_05908 [Caenorhabditis remanei]
GI:71989986 GenBank EFP06159.1 474 hypothetical protein CRE_05908 [Caenorhabditis remanei]
GI:71989986 GenBank EGT57089.1 475 CBN-MBOA-6 protein [Caenorhabditis brenneri]
GI:71989981 GenBank EGT57089.1 475 CBN-MBOA-6 protein [Caenorhabditis brenneri]
GI:71989986 RefSeq NP_001022735.1 473 Protein MBOA-6, isoform a [Caenorhabditis elegans]
GI:71989981 RefSeq NP_001022736.1 341 Protein MBOA-6, isoform b [Caenorhabditis elegans]
GI:71989981 RefSeq XP_002640991.1 491 Hypothetical protein CBG11740 [Caenorhabditis briggsae]
GI:71989986 RefSeq XP_003102280.1 474 hypothetical protein CRE_05908 [Caenorhabditis remanei]
GI:71989981 RefSeq XP_003102280.1 474 hypothetical protein CRE_05908 [Caenorhabditis remanei]
GI:71989986 SwissProt O01925.2 473 RecName: Full=Lysophospholipid acyltransferase 5; Short=LPLAT 5; AltName: Full=Probable 1-acylglycerophosphocholine O-acyltransferase; AltName: Full=Probable 1-acylglycerophosphoethanolamine O-acyltransferase; AltName: Full=Probable 1-acylglycerophosphoserine O-acyltransferase; AltName: Full=Probable lysophosphatidylcholine acyltransferase; Short=LPCAT; Short=Lyso-PC acyltransferase; AltName: Full=Probable lysophosphatidylethanolamine acyltransferase; Short=LPEAT; Short=Lyso-PE acyltransferase; AltName: Full=Probable lysophosphatidylserine acyltransferase; Short=LPSAT; Short=Lyso-PS acyltransferase [Caenorhabditis elegans]