Gene/Proteome Database (LMPD)

LMPD ID
LMP007792
Gene ID
178072
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SMS-1
Gene Symbol
sms-1
Synonyms
CELE_H21P03.3
Chromosome
IV

Proteins

Protein SMS-1, isoform a
Refseq ID NP_502169
Protein GI 392900847
UniProt ID Q9U3D4
mRNA ID NM_069768
Length 429
RefSeq Status REVIEWED
MKMSWNHQYTNYGSIADDNGDEEKAENSEGAAAEKVEKQHDDDGVVVHEETDGVASSRSSHHDKQKPGETKKSGDGKMDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE
Protein SMS-1, isoform b
Refseq ID NP_502168
Protein GI 392900843
UniProt ID Q9U3D4
mRNA ID NM_069767
Length 469
RefSeq Status REVIEWED
MSVTVEVADEETHDVPLVEQVRTTPDQNVDVKVQENNVVTTKIGPKLETIPAAKMQDDNGDEEKAENSEGAAAEKVEKQHDDDGVVVHEETDGVASSRSSHHDKQKPGETKKSGDGKMDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE
Protein SMS-1, isoform c
Refseq ID NP_001129861
Protein GI 392900849
UniProt ID Q9U3D4
mRNA ID NM_001136389
Length 352
RefSeq Status REVIEWED
MDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE
Protein SMS-1, isoform d
Refseq ID NP_001255559
Protein GI 392900845
UniProt ID H2L2K5
mRNA ID NM_001268630
Length 415
RefSeq Status REVIEWED
MQDDNGDEEKAENSEGAAAEKVEKQHDDDGVVVHEETDGVASSRSSHHDKQKPGETKKSGDGKMDDDDIITTARSSSRRICGSAASSSDSETADDAPLLPDEGPSHAVRLEMPGDKPASPHDRFPKTPLKTLVAFLMLVVAAAGNTITLSWIHERYPLTPPLPDIVFELIPKIPWGLRLCENLMIGSFVSLLVLILFHRHRWIVLRRLCFIGSILYGMRCITMMVTPVPKADEDFECSPRFGENATFSLIVMRGVWSMFGLGLNLFDNQKVVLCGDYIYSGHTLVLVVSALFIGEYSPRRFYILHWLSWLVCSVGVIFLVLSHGHYTIDVILSYFACTRVFWAYHTQAAHPSIRLSVQNHQAKEFWFPLLRWFEGDIRRPVPRRFDCPISYSQVCNAFRRVRPRGRNGAARPAFE

Gene Information

Entrez Gene ID
178072
Gene Name
Protein SMS-1
Gene Symbol
sms-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 ISS:UniProtKB C integral component of Golgi membrane
GO:0047493 ISS:UniProtKB F ceramide cholinephosphotransferase activity
GO:0033188 IEA:UniProtKB-EC F sphingomyelin synthase activity
GO:0006686 ISS:UniProtKB P sphingomyelin biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5652491 Metabolism
5652530 Metabolism of lipids and lipoproteins
5653216 Sphingolipid de novo biosynthesis
5653217 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025749 Sphingomyelin synthase-like domain

UniProt Annotations

Entry Information

Gene Name
Protein SMS-1
Protein Entry
Q9U3D4_CAEEL
UniProt ID
Q9U3D4
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=b {ECO:0000305}; IsoId=Q9U3D4-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=a {ECO:0000305}; IsoId=Q9U3D4-2; Sequence=VSP_050674; Note=No experimental confirmation available. {ECO:0000305}; Name=c; IsoId=Q9U3D4-3; Sequence=VSP_039807; Note=No experimental confirmation available.;
Catalytic Activity A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol. {ECO:0000269|PubMed:14685263}.
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. {ECO:0000269|PubMed:14685263}.
Pathway Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:14685263}.
Similarity Belongs to the sphingomyelin synthase family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007792 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392900847 RefSeq NP_502169 429 Protein SMS-1, isoform a
392900843 RefSeq NP_502168 469 Protein SMS-1, isoform b
392900849 RefSeq NP_001129861 352 Protein SMS-1, isoform c
392900845 RefSeq NP_001255559 415 Protein SMS-1, isoform d

Identical Sequences to LMP007792 proteins

Reference Database Accession Length Protein Name
GI:392900843 EMBL CAB54269.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900847 EMBL CAB09114.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900849 EMBL CAQ58114.2 352 Protein SMS-1, isoform c [Caenorhabditis elegans]
GI:392900845 EMBL CCE72098.1 415 Protein SMS-1, isoform d [Caenorhabditis elegans]
GI:392900843 SwissProt Q9U3D4.2 469 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Sphingomyelin synthase 1 [Caenorhabditis elegans]

Related Sequences to LMP007792 proteins

Reference Database Accession Length Protein Name
GI:392900849 EMBL CAB54269.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900847 EMBL CAB54269.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900845 EMBL CAB54269.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900843 EMBL CAB09114.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900849 EMBL CAB09114.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900845 EMBL CAB09114.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900843 EMBL CCE72098.1 415 Protein SMS-1, isoform d [Caenorhabditis elegans]
GI:392900847 EMBL CCE72098.1 415 Protein SMS-1, isoform d [Caenorhabditis elegans]
GI:392900849 EMBL CCE72098.1 415 Protein SMS-1, isoform d [Caenorhabditis elegans]
GI:392900843 GenBank EFO93703.1 461 CRE-SMS-1 protein [Caenorhabditis remanei]
GI:392900847 GenBank EGT53363.1 418 hypothetical protein CAEBREN_17296 [Caenorhabditis brenneri]
GI:392900845 RefSeq XP_003107804.1 461 CRE-SMS-1 protein [Caenorhabditis remanei]
GI:392900843 RefSeq XP_003107804.1 461 CRE-SMS-1 protein [Caenorhabditis remanei]
GI:392900845 RefSeq NP_502168.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900847 RefSeq NP_502168.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900849 RefSeq NP_502168.2 469 Protein SMS-1, isoform b [Caenorhabditis elegans]
GI:392900847 RefSeq NP_001255559.1 415 Protein SMS-1, isoform d [Caenorhabditis elegans]
GI:392900843 RefSeq NP_001255559.1 415 Protein SMS-1, isoform d [Caenorhabditis elegans]
GI:392900845 RefSeq NP_502169.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900843 RefSeq NP_502169.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900849 RefSeq NP_502169.2 429 Protein SMS-1, isoform a [Caenorhabditis elegans]
GI:392900849 SwissProt Q9U3D4.2 469 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Sphingomyelin synthase 1 [Caenorhabditis elegans]
GI:392900847 SwissProt Q9U3D4.2 469 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Sphingomyelin synthase 1 [Caenorhabditis elegans]
GI:392900845 SwissProt Q9U3D4.2 469 RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1; AltName: Full=Sphingomyelin synthase 1 [Caenorhabditis elegans]