Gene/Proteome Database (LMPD)

LMPD ID
LMP007800
Gene ID
174131
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein ASM-1
Gene Symbol
asm-1
Synonyms
CELE_B0252.2
Chromosome
II

Proteins

Protein ASM-1
Refseq ID NP_495415
Protein GI 25149810
UniProt ID Q10916
mRNA ID NM_063014
Length 564
RefSeq Status REVIEWED
MRIIYLISTVLLIYTNATVLRTKESIQNKVTYDKYGFQPLCISCTGLISVASFFLKFDVSEPVILEFATIVCKLFAKQPWAVCDGISSQFRDEFFYVFRRLANESPSQICGIILPDCADPTDPSESGWMVALPPKPKRTRISKKKVQKKPNMSMSQNLNVLQLTDLHVDFEYKYPSEANCDDPVCCRVSVSEPKKAAGYWGSVGKCDIPFWTVENMLSHINKTHMIDMVIMTGDYINHVDWEYSIEEHLSVLRKLHRLVQNTFPSTPIYWALGNHEGVPVNSFAPHSVDERFWPTWLYKEFQTMSGPWLSEGAKDSLLKRGSYSTQVMDGLKLITLNTGFCEVTNFFLYLNQSDPDSSMSWFVKELFESEKKGEQVYVLAHIPPGDSECLEGWAFNYYRVIQRFSSTIAAQFFGHDHLDYFTVFYEDMHNVSSKPISVGYASPSVTTFEYQNPAYRIYEIDPYNKFKIVDFTTYYADLEKATEDKKPVWEKLYSARQAHGMDDLSPLSWNKVIQKLFTSEKKREKFYQYAFRNFSPQCDSTCQMQLMCNLRMGHHNSTLYCPTF

Gene Information

Entrez Gene ID
174131
Gene Name
Protein ASM-1
Gene Symbol
asm-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IDA:UniProtKB C extracellular region
GO:0005764 IDA:WormBase C lysosome
GO:0016798 IEA:UniProtKB-KW F hydrolase activity, acting on glycosyl bonds
GO:0004767 IDA:UniProtKB F sphingomyelin phosphodiesterase activity
GO:0046513 IDA:UniProtKB P ceramide biosynthetic process
GO:0006685 IDA:UniProtKB P sphingomyelin catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase

UniProt Annotations

Entry Information

Gene Name
Protein ASM-1
Protein Entry
Q10916_CAEEL
UniProt ID
Q10916
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Developmental Stage Preferentially expressed in embryos, lower expression in later development.
Function Converts sphingomyelin to ceramide.
Miscellaneous Does not require zinc ions as a cofactor.
Miscellaneous There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinase has been found in worms. {ECO:0000250|UniProtKB:P17405, ECO:0000269|PubMed:9603947}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the acid sphingomyelinase family.
Similarity Contains 1 saposin B-type domain.
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP007800 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25149810 RefSeq NP_495415 564 Protein ASM-1

Identical Sequences to LMP007800 proteins

Reference Database Accession Length Protein Name
GI:25149810 EMBL CCD61537.1 564 Protein ASM-1 [Caenorhabditis elegans]
GI:25149810 SwissProt Q10916.2 564 RecName: Full=Sphingomyelin phosphodiesterase 1; AltName: Full=Acid sphingomyelinase 1; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007800 proteins

Reference Database Accession Length Protein Name
GI:25149810 EMBL CAP30378.1 562 Protein CBR-ASM-1 [Caenorhabditis briggsae]
GI:25149810 GenBank ABZ31496.1 605 Sequence 5434 from patent US 7314974
GI:25149810 GenBank EFP07393.1 561 CRE-ASM-1 protein [Caenorhabditis remanei]
GI:25149810 GenBank EGT46124.1 568 hypothetical protein CAEBREN_07995 [Caenorhabditis brenneri]
GI:25149810 RefSeq XP_002630450.1 562 C. briggsae CBR-ASM-1 protein [Caenorhabditis briggsae]
GI:25149810 RefSeq XP_003113481.1 561 CRE-ASM-1 protein [Caenorhabditis remanei]