Gene/Proteome Database (LMPD)

LMPD ID
LMP007814
Gene ID
181323
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein ASM-2
Gene Symbol
asm-2
Synonyms
CELE_ZK455.4
Chromosome
X

Proteins

Protein ASM-2
Refseq ID NP_509894
Protein GI 25152317
UniProt ID Q23498
mRNA ID NM_077493
Length 618
RefSeq Status REVIEWED
MQQPLIILGIGIVLALVSNVESGVLRKPVDEHEYEKWTNARGNEAAVPPPKYKMLRYAKKAINEPENRKMSCLFCTFAVDGVQALIAQNSTDNEIAAFLVNLCDLFDVEQPHVCKNIIYAFKDEVVFVLERSVFTPEEICGAFIANCGHSDKPLTHMWNITIPGGKPPIKPWPKIPDNKPTFKVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLKDKPIYVPAGPWGMPYLCDLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNVFLEYFPGVPVYVSIGNHEGVPQDAMAPHTMPEYDTRGPQWLYKIMSEMWSHWIPQEALDTVQYRASYAVYPKPGLKLISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELQDSENKGELVHIISHIPPGDNYCLKGWSWNFFEIVKRYENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFHFNWISPSLTTYDWLNPAYRIYEIDGGYEGATYTVKDAKTYFANVTEANMKNKEPEWVLSYDTREHYQMADFSPQSWSDLSDKLWTNTTLFRDYVRLYYRNHYNNECYTDYKCRYTFVCDIKKGRSYDESFCDHLTK

Gene Information

Entrez Gene ID
181323
Gene Name
Protein ASM-2
Gene Symbol
asm-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IDA:UniProtKB C extracellular region
GO:0005622 IDA:WormBase C intracellular
GO:0016798 IEA:UniProtKB-KW F hydrolase activity, acting on glycosyl bonds
GO:0004767 IDA:UniProtKB F sphingomyelin phosphodiesterase activity
GO:0046513 IDA:UniProtKB P ceramide biosynthetic process
GO:0006685 IDA:UniProtKB P sphingomyelin catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
IPR008139 Saposin B
IPR011001 Saposin-like
IPR007856 Saposin-like type B, 1
IPR011160 Sphingomyelin phosphodiesterase

UniProt Annotations

Entry Information

Gene Name
Protein ASM-2
Protein Entry
Q23498_CAEEL
UniProt ID
Q23498
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ;
Developmental Stage Preferentially expressed in post-embryonic development.
Function Converts sphingomyelin to ceramide.
Miscellaneous Fully active upon secretion independent of zinc ions.
Miscellaneous There are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinase has been found in worms. {ECO:0000250|UniProtKB:P17405, ECO:0000269|PubMed:9603947}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the acid sphingomyelinase family.
Similarity Contains 1 saposin B-type domain.
Subcellular Location Secreted . Note=Only the secreted form is enzymatically active.

Identical and Related Proteins

Unique RefSeq proteins for LMP007814 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25152317 RefSeq NP_509894 618 Protein ASM-2

Identical Sequences to LMP007814 proteins

Reference Database Accession Length Protein Name
GI:25152317 EMBL CAA91493.2 618 Protein ASM-2 [Caenorhabditis elegans]
GI:25152317 SwissProt Q23498.3 618 RecName: Full=Sphingomyelin phosphodiesterase 2; AltName: Full=Acid sphingomyelinase 2; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007814 proteins

Reference Database Accession Length Protein Name
GI:25152317 EMBL CAP35043.2 625 Protein CBR-ASM-2 [Caenorhabditis briggsae]
GI:25152317 GenBank ABZ32972.1 572 Sequence 6910 from patent US 7314974
GI:25152317 GenBank EFO89624.1 612 CRE-ASM-2 protein [Caenorhabditis remanei]
GI:25152317 GenBank EGT29962.1 618 hypothetical protein CAEBREN_28121 [Caenorhabditis brenneri]
GI:25152317 RefSeq XP_002643985.1 568 C. briggsae CBR-ASM-2 protein [Caenorhabditis briggsae]
GI:25152317 RefSeq XP_003109482.1 612 CRE-ASM-2 protein [Caenorhabditis remanei]