Gene/Proteome Database (LMPD)
Proteins
| Protein ADS-1 | |
|---|---|
| Refseq ID | NP_497185 |
| Protein GI | 17556096 |
| UniProt ID | O45218 |
| mRNA ID | NM_064784 |
| Length | 597 |
| RefSeq Status | REVIEWED |
| MSASYQTIEHDVPQSYRDKILKWNGWGYSDSQFAINKDGHVTFTGDKYEISGKVMPHFRPWFENYLGIDLGFVSPAQKLSDVIIDAPVENEDIIEFLQENKISFSNEARIRLMRGHGHTVHDMINLREGKIPRLPDIVVWPKSEHEIVKIIEGAMSHNCAIIPIGGGTSVTNALDTPETEKRAVISMDMALLDKILWIDRENLTCRAQAGIVGQSLERQLNKKGFTCGHEPDSIEFSTLGGWVSTRASGMKKNKYGNIEDLVVHLNFVCPKGIIQKQCQVPRMSSGPDIHQIILGSEGTLGVVSEVTIKIFPIPEVKRFGSFVFPNFESGVNFFREVAIQRCQPASLRLMDNDQFVMGQALKVASDSWWADLKSSVSKMYITSWKGFKVDEICAATCVYEGNREEVDQHEERLNKLAEQFHGVVGGAENGQYGYRLTFAIAYLRDLGMNHGVLGESFETSVPWDKVLSLCRNVKELMKREAKAQGVTHPVLANCRVTQVYDAGACVYFYFGFNARGLKNGLEVYDRIETAARDEIIACGGSISHHHGVGKIRKQWMLTTNGAVGIALLKAIKSELDPANIFASANLIDIIGSPHCKL | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005777 | IEA:UniProtKB-KW | C | peroxisome |
| GO:0008609 | ISS:UniProtKB | F | alkylglycerone-phosphate synthase activity |
| GO:0071949 | ISS:UniProtKB | F | FAD binding |
| GO:0008762 | IEA:InterPro | F | UDP-N-acetylmuramate dehydrogenase activity |
| GO:0008611 | ISS:UniProtKB | P | ether lipid biosynthetic process |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5652681 | Plasmalogen biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR025650 | Alkyldihydroxyacetonephosphate synthase |
| IPR016169 | CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 |
| IPR016166 | FAD-binding, type 2 |
| IPR016167 | FAD-binding, type 2, subdomain 1 |
| IPR004113 | FAD-linked oxidase, C-terminal |
| IPR016164 | FAD-linked oxidase-like, C-terminal |
| IPR006094 | FAD linked oxidase, N-terminal |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion. |
| Cofactor | Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; |
| Function | Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. {ECO:0000250}. |
| Pathway | Glycerolipid metabolism; ether lipid biosynthesis. |
| Similarity | Belongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO:0000305}. |
| Similarity | Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule:PRU00718}. |
| Subcellular Location | Peroxisome. |
| Subunit | Homodimer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007822 (as displayed in Record Overview)
Identical Sequences to LMP007822 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:17556096 | EMBL | CAA05690.1 | 597 | alkyl-dihydroxyacetonephosphate synthase [Caenorhabditis elegans] |
| GI:17556096 | EMBL | CCD73794.1 | 597 | Protein ADS-1 [Caenorhabditis elegans] |
| GI:17556096 | SwissProt | O45218.1 | 597 | RecName: Full=Alkyldihydroxyacetonephosphate synthase; Short=Alkyl-DHAP synthase; AltName: Full=Alkylglycerone-phosphate synthase [Caenorhabditis elegans] |
Related Sequences to LMP007822 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:17556096 | EMBL | CAP33892.1 | 597 | Protein CBR-ADS-1 [Caenorhabditis briggsae] |
| GI:17556096 | GenBank | EFP08408.1 | 597 | CRE-ADS-1 protein [Caenorhabditis remanei] |
| GI:17556096 | GenBank | EGT47786.1 | 597 | CBN-ADS-1 protein [Caenorhabditis brenneri] |
| GI:17556096 | GenBank | EYC27684.1 | 594 | hypothetical protein Y032_0008g128 [Ancylostoma ceylanicum] |
| GI:17556096 | RefSeq | XP_002640829.1 | 597 | C. briggsae CBR-ADS-1 protein [Caenorhabditis briggsae] |
| GI:17556096 | RefSeq | XP_003100881.1 | 597 | CRE-ADS-1 protein [Caenorhabditis remanei] |