Gene/Proteome Database (LMPD)
Proteins
| Protein SMS-3 | |
|---|---|
| Refseq ID | NP_497425 |
| Protein GI | 17555564 |
| UniProt ID | Q965Q4 |
| mRNA ID | NM_065024 |
| Length | 340 |
| RefSeq Status | REVIEWED |
| MGSVSKTVISARGASPDDEQNGTKNGISNGSEWAKCIFLFFFLFIAGMSNWAVLAYTHDYVPRESLPDIVFSLVSEQRWASSLGDFCVALCIVMLGALLVIHQHRGTILKRVVFCAGTLYAMRSVTLAATQLPSGYTDNQGRCRDQVESEAGVFFGRLFEQTIRIGFQSKDQMLCGDLLFSGHTLVMVTCSLAVAYYLPKSIKPLQWVSHVACLIGMICMTISRTHYTIDVVIAYWLSNMVFRMYHAYCEVDMCMERRKSILYSWWPCRIVDWLEQDIVPGRLENRCQLPWRRSTPRGQERGGASAESSDSSVTMCDNITTSHHQKHVSISSSSTYPLPC | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | NAS:UniProtKB | C | integral component of membrane |
| GO:0047493 | ISS:UniProtKB | F | ceramide cholinephosphotransferase activity |
| GO:0033188 | IEA:UniProtKB-EC | F | sphingomyelin synthase activity |
| GO:0006686 | ISS:UniProtKB | P | sphingomyelin biosynthetic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR025749 | Sphingomyelin synthase-like domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol. |
| Function | Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity). |
| Pathway | Lipid metabolism; sphingolipid metabolism. |
| Similarity | Belongs to the sphingomyelin synthase family. |
| Subcellular Location | Membrane ; Multi-pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP007823 (as displayed in Record Overview)
Identical Sequences to LMP007823 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:17555564 | EMBL | CCD73749.1 | 340 | Protein SMS-3 [Caenorhabditis elegans] |
| GI:17555564 | SwissProt | Q965Q4.1 | 340 | RecName: Full=Putative phosphatidylcholine:ceramide cholinephosphotransferase 3; AltName: Full=Sphingomyelin synthase 3 [Caenorhabditis elegans] |
Related Sequences to LMP007823 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:17555564 | EMBL | CAP30876.2 | 297 | Protein CBR-SMS-3 [Caenorhabditis briggsae] |
| GI:17555564 | EMBL | CDJ98059.1 | 353 | Sphingomyelin synthase-related 2 [Haemonchus contortus] |
| GI:17555564 | GenBank | EFP06128.1 | 413 | CRE-SMS-3 protein [Caenorhabditis remanei] |
| GI:17555564 | GenBank | EGT57164.1 | 355 | CBN-SMS-3 protein [Caenorhabditis brenneri] |
| GI:17555564 | RefSeq | XP_002640954.1 | 314 | C. briggsae CBR-SMS-3 protein, partial [Caenorhabditis briggsae] |
| GI:17555564 | RefSeq | XP_003102249.1 | 413 | CRE-SMS-3 protein [Caenorhabditis remanei] |