Gene/Proteome Database (LMPD)

LMPD ID
LMP007827
Gene ID
177819
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein FAT-4
Gene Symbol
fat-4
Synonyms
CELE_T13F2.1
Alternate Names
Protein FAT-4
Chromosome
IV
EC Number
1.14.19.-

Proteins

Protein FAT-4, isoform a
Refseq ID NP_001255423
Protein GI 392900185
UniProt ID G5EG11
mRNA ID NM_001268494
Length 447
RefSeq Status REVIEWED
MVLREQEHEPFFIKIDGKWCQIDDAVLRSHPGGSAITTYKNMDATTVFHTFHTGSKEAYQWLTELKKECPTQEPEIPDIKDDPIKGIDDVNMGTFNISEKRSAQINKSFTDLRMRVRAEGLMDGSPLFYIRKILETIFTILFAFYLQYHTYYLPSAILMGVAWQQLGWLIHEFAHHQLFKNRYYNDLASYFVGNFLQGFSSGGWKEQHNVHHAATNVVGRDGDLDLVPFYATVAEHLNNYSQDSWVMTLFRWQHVHWTFMLPFLRLSWLLQSIIFVSQMPTHYYDYYRNTAIYEQVGLSLHWAWSLGQLYFLPDWSTRIMFFLVSHLVGGFLLSHVVTFNHYSVEKFALSSNIMSNYACLQIMTTRNMRPGRFIDWLWGGLNYQIEHHLFPTMPRHNLNTVMPLVKEFAAANGLPYMVDDYFTGFWLEIEQFRNIANVAAKLTKKIA
Protein FAT-4, isoform b
Refseq ID NP_001255424
Protein GI 392900187
UniProt ID G5EG11
mRNA ID NM_001268495
Length 356
RefSeq Status REVIEWED
MGTFNISEKRSAQINKSFTDLRMRVRAEGLMDGSPLFYIRKILETIFTILFAFYLQYHTYYLPSAILMGVAWQQLGWLIHEFAHHQLFKNRYYNDLASYFVGNFLQGFSSGGWKEQHNVHHAATNVVGRDGDLDLVPFYATVAEHLNNYSQDSWVMTLFRWQHVHWTFMLPFLRLSWLLQSIIFVSQMPTHYYDYYRNTAIYEQVGLSLHWAWSLGQLYFLPDWSTRIMFFLVSHLVGGFLLSHVVTFNHYSVEKFALSSNIMSNYACLQIMTTRNMRPGRFIDWLWGGLNYQIEHHLFPTMPRHNLNTVMPLVKEFAAANGLPYMVDDYFTGFWLEIEQFRNIANVAAKLTKKIA
Protein FAT-4, isoform c
Refseq ID NP_001255425
Protein GI 392900189
UniProt ID G5EG11
mRNA ID NM_001268496
Length 55
RefSeq Status REVIEWED
MPRHNLNTVMPLVKEFAAANGLPYMVDDYFTGFWLEIEQFRNIANVAAKLTKKIA

Gene Information

Entrez Gene ID
177819
Gene Name
Protein FAT-4
Gene Symbol
fat-4
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IDA:WormBase F stearoyl-CoA 9-desaturase activity
GO:0006636 IMP:WormBase P unsaturated fatty acid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5653462 Linoleic acid (LA) metabolism
5653288 PPARA activates gene expression
5653461 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5653460 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR005804 Fatty acid desaturase, type 1
IPR012171 Fatty acid/sphingolipid desaturase

UniProt Annotations

Entry Information

Gene Name
Protein FAT-4
Protein Entry
FAT4_CAEEL
UniProt ID
G5EG11
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=a; IsoId=G5EG11-1; Sequence=Displayed; Name=b; IsoId=G5EG11-2; Sequence=VSP_047789; Name=c; IsoId=G5EG11-3; Sequence=VSP_047788;
Function Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) to generate arachidonic acid (20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:9845325, ECO:0000269|PubMed:9917342}.
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:9845325, ECO:0000269|PubMed:9917342}.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Similarity Contains 1 cytochrome b5 heme-binding domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007827 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392900185 RefSeq NP_001255423 447 Protein FAT-4, isoform a
392900187 RefSeq NP_001255424 356 Protein FAT-4, isoform b
392900189 RefSeq NP_001255425 55 Protein FAT-4, isoform c

Identical Sequences to LMP007827 proteins

Reference Database Accession Length Protein Name
GI:392900187 EMBL CBL43456.1 356 Protein FAT-4, isoform b [Caenorhabditis elegans]
GI:392900189 EMBL CBZ01822.1 55 Protein FAT-4, isoform c [Caenorhabditis elegans]
GI:392900185 GenBank AFD40698.1 447 Sequence 2 from patent US 8124838
GI:392900185 GenBank AFK97131.1 447 Sequence 20 from patent US 8158392
GI:392900185 GenBank AFL61024.1 447 Sequence 20 from patent US 8106226
GI:392900185 GenBank AGB67179.1 447 Sequence 20 from patent US 8288572
GI:392900185 GenBank AHE22357.1 447 Sequence 20 from patent US 8575377
GI:392900185 SwissProt G5EG11.1 447 RecName: Full=Delta(5) fatty acid desaturase fat-4; AltName: Full=Fatty acid desaturase 4 [Caenorhabditis elegans]

Related Sequences to LMP007827 proteins

Reference Database Accession Length Protein Name
GI:392900187 EMBL CAB61031.1 447 Protein FAT-4, isoform a [Caenorhabditis elegans]
GI:392900189 EMBL CAB61031.1 447 Protein FAT-4, isoform a [Caenorhabditis elegans]
GI:392900187 GenBank AAC95143.1 447 delta 5 fatty acid desaturase [Caenorhabditis elegans]
GI:392900189 GenBank AAC95143.1 447 delta 5 fatty acid desaturase [Caenorhabditis elegans]
GI:392900189 GenBank AAD13294.1 447 delta5-fatty acid desaturase [Caenorhabditis elegans]
GI:392900187 GenBank AAD13294.1 447 delta5-fatty acid desaturase [Caenorhabditis elegans]
GI:392900185 GenBank ABZ32169.1 454 Sequence 6107 from patent US 7314974
GI:392900185 GenBank EFP04845.1 447 CRE-FAT-4 protein [Caenorhabditis remanei]
GI:392900185 GenBank EGT37844.1 447 hypothetical protein CAEBREN_21723 [Caenorhabditis brenneri]
GI:392900185 GenBank EGT37907.1 447 hypothetical protein CAEBREN_17271 [Caenorhabditis brenneri]
GI:392900189 GenBank AFK97131.1 447 Sequence 20 from patent US 8158392
GI:392900187 GenBank AFK97131.1 447 Sequence 20 from patent US 8158392
GI:392900187 GenBank AFL61024.1 447 Sequence 20 from patent US 8106226
GI:392900189 GenBank AFL61024.1 447 Sequence 20 from patent US 8106226
GI:392900185 PIR - 454 protein T13F2.1 [imported] - Caenorhabditis elegans [Caenorhabditis elegans]
GI:392900185 RefSeq XP_003102806.1 447 CRE-FAT-4 protein [Caenorhabditis remanei]
GI:392900187 SwissProt G5EG11.1 447 RecName: Full=Delta(5) fatty acid desaturase fat-4; AltName: Full=Fatty acid desaturase 4 [Caenorhabditis elegans]
GI:392900189 SwissProt G5EG11.1 447 RecName: Full=Delta(5) fatty acid desaturase fat-4; AltName: Full=Fatty acid desaturase 4 [Caenorhabditis elegans]