Gene/Proteome Database (LMPD)

LMPD ID
LMP007828
Gene ID
177820
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein FAT-3
Gene Symbol
fat-3
Synonyms
CELE_W08D2.4
Alternate Names
Protein FAT-3
Chromosome
IV
EC Number
1.14.19.-

Proteins

Protein FAT-3, isoform a
Refseq ID NP_001255426
Protein GI 392900191
UniProt ID Q23221
mRNA ID NM_001268497
Length 443
RefSeq Status REVIEWED
MVVDKNASGLRMKVDGKWLYLSEELVKKHPGGAVIEQYRNSDATHIFHAFHEGSSQAYKQLDLLKKHGEHDEFLEKQLEKRLDKVDINVSAYDVSVAQEKKMVESFEKLRQKLHDDGLMKANETYFLFKAISTLSIMAFAFYLQYLGWYITSACLLALAWQQFGWLTHEFCHQQPTKNRPLNDTISLFFGNFLQGFSRDWWKDKHNTHHAATNVIDHDGDIDLAPLFAFIPGDLCKYKASFEKAILKIVPYQHLYFTAMLPMLRFSWTGQSVQWVFKENQMEYKVYQRNAFWEQATIVGHWAWVFYQLFLLPTWPLRVAYFIISQMGGGLLIAHVVTFNHNSVDKYPANSRILNNFAALQILTTRNMTPSPFIDWLWGGLNYQIEHHLFPTMPRCNLNACMKYVKEWCKENNLPYLVDDYFDGYAMNLQQLKNMAEHIQAKAA
Protein FAT-3, isoform b
Refseq ID NP_001255427
Protein GI 392900193
UniProt ID Q23221
mRNA ID NM_001268498
Length 185
RefSeq Status REVIEWED
MLPMLRFSWTGQSVQWVFKENQMEYKVYQRNAFWEQATIVGHWAWVFYQLFLLPTWPLRVAYFIISQMGGGLLIAHVVTFNHNSVDKYPANSRILNNFAALQILTTRNMTPSPFIDWLWGGLNYQIEHHLFPTMPRCNLNACMKYVKEWCKENNLPYLVDDYFDGYAMNLQQLKNMAEHIQAKAA
Protein FAT-3, isoform c
Refseq ID NP_001255428
Protein GI 392900195
UniProt ID Q23221
mRNA ID NM_001268499
Length 77
RefSeq Status REVIEWED
MTPSPFIDWLWGGLNYQIEHHLFPTMPRCNLNACMKYVKEWCKENNLPYLVDDYFDGYAMNLQQLKNMAEHIQAKAA

Gene Information

Entrez Gene ID
177820
Gene Name
Protein FAT-3
Gene Symbol
fat-3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IC:WormBase C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IDA:WormBase F stearoyl-CoA 9-desaturase activity
GO:0014055 IMP:WormBase P acetylcholine secretion, neurotransmission
GO:0040002 IMP:WormBase P collagen and cuticulin-based cuticle development
GO:0030421 IMP:WormBase P defecation
GO:0032456 IMP:WormBase P endocytic recycling
GO:0040011 IMP:WormBase P locomotion
GO:0035264 IMP:WormBase P multicellular organism growth
GO:0006936 IMP:WormBase P muscle contraction
GO:0018991 IMP:WormBase P oviposition
GO:0043050 IMP:WormBase P pharyngeal pumping
GO:0008104 IMP:WormBase P protein localization
GO:0045088 IMP:WormBase P regulation of innate immune response
GO:0001820 IMP:WormBase P serotonin secretion
GO:0006636 IMP:WormBase P unsaturated fatty acid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5653462 Linoleic acid (LA) metabolism
5652530 Metabolism of lipids and lipoproteins
5653461 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5653460 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR005804 Fatty acid desaturase, type 1
IPR012171 Fatty acid/sphingolipid desaturase

UniProt Annotations

Entry Information

Gene Name
Protein FAT-3
Protein Entry
FAT3_CAEEL
UniProt ID
Q23221
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=a; IsoId=Q23221-1; Sequence=Displayed; Name=b; IsoId=Q23221-2; Sequence=VSP_047787; Name=c; IsoId=Q23221-3; Sequence=VSP_047786;
Function Delta(6) fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)) to gamma-linolenic acid (Delta(6,9,12)-18:3, or C18:3(n-6)). {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:9480865}.
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000269|PubMed:11972048, ECO:0000269|PubMed:9480865}.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Similarity Contains 1 cytochrome b5 heme-binding domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007828 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392900191 RefSeq NP_001255426 443 Protein FAT-3, isoform a
392900193 RefSeq NP_001255427 185 Protein FAT-3, isoform b
392900195 RefSeq NP_001255428 77 Protein FAT-3, isoform c

Identical Sequences to LMP007828 proteins

Reference Database Accession Length Protein Name
GI:392900191 EMBL CAA94233.2 443 Protein FAT-3, isoform a [Caenorhabditis elegans]
GI:392900193 EMBL CBZ01799.1 185 Protein FAT-3, isoform b [Caenorhabditis elegans]
GI:392900195 EMBL CBZ01800.1 77 Protein FAT-3, isoform c [Caenorhabditis elegans]
GI:392900191 GenBank AAW18133.1 443 Sequence 14 from patent US 6825017
GI:392900191 GenBank ACH17686.1 443 Sequence 14 from patent US 7402735
GI:392900191 GenBank ADR85378.1 443 Sequence 53 from patent US 7736884
GI:392900191 GenBank AFD40702.1 443 Sequence 14 from patent US 8124838
GI:392900191 SwissProt Q23221.2 443 RecName: Full=Delta(6)-fatty-acid desaturase fat-3; AltName: Full=Fatty acid desaturase 3 [Caenorhabditis elegans]

Related Sequences to LMP007828 proteins

Reference Database Accession Length Protein Name
GI:392900191 EMBL CBL59065.1 443 unnamed protein product [Caenorhabditis elegans]
GI:392900191 EMBL CBL66603.1 443 unnamed protein product [Caenorhabditis elegans]
GI:392900191 EMBL CBL66667.1 443 unnamed protein product [Caenorhabditis elegans]
GI:392900191 EMBL CBL63569.1 443 unnamed protein product [Caenorhabditis elegans]
GI:392900191 EMBL CBL63633.1 443 unnamed protein product [Caenorhabditis elegans]
GI:392900191 EMBL CBL63697.1 443 unnamed protein product [Caenorhabditis elegans]
GI:392900195 GenBank AAW18133.1 443 Sequence 14 from patent US 6825017
GI:392900193 GenBank AAW18133.1 443 Sequence 14 from patent US 6825017
GI:392900193 GenBank ACH17686.1 443 Sequence 14 from patent US 7402735
GI:392900195 GenBank ACH17686.1 443 Sequence 14 from patent US 7402735
GI:392900193 GenBank ADR85378.1 443 Sequence 53 from patent US 7736884
GI:392900195 GenBank ADR85378.1 443 Sequence 53 from patent US 7736884
GI:392900193 GenBank AFD40702.1 443 Sequence 14 from patent US 8124838
GI:392900195 GenBank AFD40702.1 443 Sequence 14 from patent US 8124838
GI:392900193 RefSeq NP_001255426.1 443 Protein FAT-3, isoform a [Caenorhabditis elegans]
GI:392900195 RefSeq NP_001255426.1 443 Protein FAT-3, isoform a [Caenorhabditis elegans]
GI:392900193 SwissProt Q23221.2 443 RecName: Full=Delta(6)-fatty-acid desaturase fat-3; AltName: Full=Fatty acid desaturase 3 [Caenorhabditis elegans]
GI:392900195 SwissProt Q23221.2 443 RecName: Full=Delta(6)-fatty-acid desaturase fat-3; AltName: Full=Fatty acid desaturase 3 [Caenorhabditis elegans]