Gene/Proteome Database (LMPD)

LMPD ID
LMP007834
Gene ID
181252
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein MBOA-7
Gene Symbol
mboa-7
Synonyms
CELE_F14F3.3
Chromosome
X

Proteins

Protein MBOA-7
Refseq ID NP_509760
Protein GI 133958222
UniProt ID Q19468
mRNA ID NM_077359
Length 453
RefSeq Status REVIEWED
MENILGLMSKDDWIYTGLLLFSFGASCYVRKIGNNILASGALGFAMSLFIIGPKIVYSLGICSIAISIQLLANKKSTPLYVFLTTFTYLMFVRFAHYILPVNEVASHTNVIQLIITLRIIGITFEENDAWVHKSDENPTKRYLTELPTILEKFAYFYHFCGLFTGPYYTYQMLIDSQNPILKSWDPTLEVKSRFVRLLWSVPVFVITNHYFPLDILRSDAIWEVSFFTRLVYAALIFVVFKTRVYSAWAIAESICVILGIGIYPAASNPKIIMGPTDLNAFDKLKTRENIEMSSDAIVNLDIPKVEFSDGFRDGMKAWNRSVQTWLALYVHSRVKVMRVETTMLVSAVWHGTYAGYFMSFGVVAMCAILEDVIFKLVPVDTETGVRPKWFRILYTHTIRCRGFEMLATGFLLKNAYDVHHFWSSIYYWLPLLCIPFYIYSAKISKPKKAQKSE

Gene Information

Entrez Gene ID
181252
Gene Name
Protein MBOA-7
Gene Symbol
mboa-7
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:WormBase C intracellular membrane-bounded organelle
GO:0008374 IDA:WormBase F O-acyltransferase activity
GO:0035264 IGI:WormBase P multicellular organism growth
GO:0002119 IMP:WormBase P nematode larval development
GO:0018991 IMP:WormBase P oviposition
GO:0006661 IDA:WormBase P phosphatidylinositol biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT

UniProt Annotations

Entry Information

Gene Name
Protein MBOA-7
Protein Entry
Q19468_CAEEL
UniProt ID
Q19468
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylinositol = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylinositol.
Catalytic Activity Acyl-[acyl-carrier-protein] + 1-acyl-sn- glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn- glycerol 3-phosphate.
Disruption Phenotype Mutants show larval arrest at an early developmental stage and egg-laying defects; 14% of mutants accumulate unlaid eggs that hatched internally.
Function Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acyl-sn-glycero-3-phosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA or eicosapentaenoic acid (EPA) as the acyl donor. Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
Pathway Lipid metabolism; phospholipid metabolism.
Similarity Belongs to the membrane-bound acyltransferase family.
Subcellular Location Membrane ; Multi-pass membrane protein .
Tissue Specificity Expressed ubiquitously throughout development from early embryo to larval and adult stages. In adults, strongly expressed in pharyngeal muscle, body wall muscle, vulval cells, distal tip cells, intestinal cells and spermatheca.

Identical and Related Proteins

Unique RefSeq proteins for LMP007834 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
133958222 RefSeq NP_509760 453 Protein MBOA-7

Identical Sequences to LMP007834 proteins

Reference Database Accession Length Protein Name
GI:133958222 EMBL CAA90185.2 453 Protein MBOA-7 [Caenorhabditis elegans]
GI:133958222 GenBank ABV66274.1 453 lysophosphatidylinositol acyltransferase [Caenorhabditis elegans]
GI:133958222 SwissProt Q19468.2 453 RecName: Full=Lysophospholipid acyltransferase 7; Short=LPLAT 7; AltName: Full=1-acylglycerophosphatidylinositol O-acyltransferase; AltName: Full=Lysophosphatidylinositol acyltransferase; Short=LPIAT; Short=Lyso-PI acyltransferase; AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 7 [Caenorhabditis elegans]

Related Sequences to LMP007834 proteins

Reference Database Accession Length Protein Name
GI:133958222 EMBL CAP25198.1 452 Protein CBR-MBOA-7 [Caenorhabditis briggsae]
GI:133958222 GenBank EFO89701.1 455 CRE-MBOA-7 protein [Caenorhabditis remanei]
GI:133958222 GenBank EGT59425.1 455 CBN-MBOA-7 protein [Caenorhabditis brenneri]
GI:133958222 RefSeq XP_002644127.1 452 C. briggsae CBR-TAG-289 protein [Caenorhabditis briggsae]
GI:133958222 RefSeq XP_003109559.1 455 CRE-MBOA-7 protein [Caenorhabditis remanei]
GI:133958222 SwissProt A8WXS4.1 452 RecName: Full=Lysophospholipid acyltransferase 7; Short=LPLAT 7; AltName: Full=1-acylglycerophosphatidylinositol O-acyltransferase; AltName: Full=Lysophosphatidylinositol acyltransferase; Short=LPIAT; Short=Lyso-PI acyltransferase; AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 7 [Caenorhabditis briggsae]