Gene/Proteome Database (LMPD)

LMPD ID
LMP007847
Gene ID
173120
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein ASAH-1
Gene Symbol
asah-1
Synonyms
CELE_K11D2.2
Alternate Names
Protein ASAH-1
Chromosome
I
EC Number
3.5.1.23

Proteins

Protein ASAH-1
Refseq ID NP_493173
Protein GI 17508209
UniProt ID O45686
mRNA ID NM_060772
Length 393
RefSeq Status REVIEWED
MLRELSVLLLVAVCAAKHVELPAPFKDHCILDDKQNLYDPSKQFDIKWYDVNLDLPPSERWVQIATANKEHIADLIGVLINLITPWFPNAIDFVDDVFGDLAPKLAQPYRDEIFSIANATGIPLGQITMYNIFYEIFTVCTSVIAQDKDGHVFHARNLDFGLFMGWDPVLHDWQISQKLRKMIINVNWLKDGKLLYKSNNFAGYIGIYNGLKPNAFSLTADDRFQLVGGYYGILKWVFGLEADGKWMSWLARETLETKTTYLDAKEHLMNTPMLSPVYFILGGSKKDEGCIIARSLDKTALLTEMATSPHGWYLLETNYDQGTEDLYLDDRDTPGFRCMDKLTQKNVGFEGIFNVLSSRTNLNKLTTYTVLMSVETSRFETILQSCPGECYPW

Gene Information

Entrez Gene ID
173120
Gene Name
Protein ASAH-1
Gene Symbol
asah-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0017040 IEA:UniProtKB-EC F ceramidase activity
GO:0006665 IEA:UniProtKB-UniPathway P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
cel04142 Lysosome
cel01100 Metabolic pathways
cel00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5653416 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016699 Acid_ceramidase-like
IPR029130 Acid ceramidase, N-terminal
IPR029132 Choloylglycine hydrolase/NAAA C-terminal

UniProt Annotations

Entry Information

Gene Name
Protein ASAH-1
Protein Entry
ASAH1_CAEEL
UniProt ID
O45686
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity N-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Function Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. {ECO:0000250}.
Interaction Q9TYY1:lag-1; NbExp=1; IntAct=EBI-324508, EBI-324482; Q9XUQ4:vps-39; NbExp=1; IntAct=EBI-324508, EBI-318975;
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the acid ceramidase family. {ECO:0000305}.
Subcellular Location Lysosome {ECO:0000250}.
Subunit Heterodimer of one alpha and one beta subunit. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007847 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17508209 RefSeq NP_493173 393 Protein ASAH-1

Identical Sequences to LMP007847 proteins

Reference Database Accession Length Protein Name
GI:17508209 EMBL CAB05556.1 393 Protein ASAH-1 [Caenorhabditis elegans]
GI:17508209 SwissProt O45686.1 393 RecName: Full=Acid ceramidase; AltName: Full=Acylsphingosine amidohydrolase 1; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007847 proteins

Reference Database Accession Length Protein Name
GI:17508209 EMBL CAP33700.1 396 Protein CBR-ASAH-1 [Caenorhabditis briggsae]
GI:17508209 GenBank EFO91037.1 395 CRE-ASAH-1 protein [Caenorhabditis remanei]
GI:17508209 GenBank EGT31387.1 395 hypothetical protein CAEBREN_30192 [Caenorhabditis brenneri]
GI:17508209 GenBank EGT52618.1 395 hypothetical protein CAEBREN_00023 [Caenorhabditis brenneri]
GI:17508209 RefSeq XP_002646404.1 396 C. briggsae CBR-ASAH-1 protein [Caenorhabditis briggsae]
GI:17508209 RefSeq XP_003094688.1 395 CRE-ASAH-1 protein [Caenorhabditis remanei]