Gene/Proteome Database (LMPD)

LMPD ID
LMP007848
Gene ID
173389
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SPTL-1
Gene Symbol
sptl-1
Synonyms
CELE_C23H3.4
Alternate Names
Protein SPTL-1
Chromosome
II
EC Number
2.3.1.50

Proteins

Protein SPTL-1, isoform a
Refseq ID NP_001021978
Protein GI 71982617
UniProt ID P91079
mRNA ID NM_001026807
Length 458
RefSeq Status REVIEWED
MGFLPDSWHFYIETLLVALLAYVVMRNRSKRQQEKLSKKLTERQKDELIADWTPEPLVPETPQDHPVLNPKYADGKMTKDVSIDGEKYLNMASTNFLSFIGVKRIEDRAKQTIFKYGVGSCGPRGFYGTVDVHLDLEKELAKFMGCEEAVLYSYGFATVSSAIPAYAKKGDVIFVDEGVNFAIQKGLQASRSRVEYFKHNDMEHLERLLLEQEQRDKKDPKKAKSVRRFIVVEGLYVNYADLCPLPKIIEFKWRFKVRVFIDESWSFGVIGKTGRGVTEHFNVPMEDVDMVMASLENALASTGGFCVGRSYVVGHQRLSGLGYCFSASLPPLLATAASEAISIIDEEPSRVQKVTEMAINGQKKLQDALSGSKFSLQGCPESPMKHIYYNGEDEEKQLDTFVETVFTKNHLLLTRARYLDKDELFKIRPSIRVMFQHDLTEEEIQRAVDAIRVVAHKF
Protein SPTL-1, isoform b
Refseq ID NP_001021979
Protein GI 71982625
UniProt ID P91079
mRNA ID NM_001026808
Length 434
RefSeq Status REVIEWED
MRNRSKRQQEKLSKKLTERQKDELIADWTPEPLVPETPQDHPVLNPKYADGKMTKDVSIDGEKYLNMASTNFLSFIGVKRIEDRAKQTIFKYGVGSCGPRGFYGTVDVHLDLEKELAKFMGCEEAVLYSYGFATVSSAIPAYAKKGDVIFVDEGVNFAIQKGLQASRSRVEYFKHNDMEHLERLLLEQEQRDKKDPKKAKSVRRFIVVEGLYVNYADLCPLPKIIEFKWRFKVRVFIDESWSFGVIGKTGRGVTEHFNVPMEDVDMVMASLENALASTGGFCVGRSYVVGHQRLSGLGYCFSASLPPLLATAASEAISIIDEEPSRVQKVTEMAINGQKKLQDALSGSKFSLQGCPESPMKHIYYNGEDEEKQLDTFVETVFTKNHLLLTRARYLDKDELFKIRPSIRVMFQHDLTEEEIQRAVDAIRVVAHKF

Gene Information

Entrez Gene ID
173389
Gene Name
Protein SPTL-1
Gene Symbol
sptl-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0004758 IEA:UniProtKB-EC F serine C-palmitoyltransferase activity
GO:0009058 IEA:InterPro P biosynthetic process
GO:0045197 IMP:UniProtKB P establishment or maintenance of epithelial cell apical/basal polarity
GO:0006665 IEA:UniProtKB-UniPathway P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
cel01100 Metabolic pathways
cel00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5653216 Sphingolipid de novo biosynthesis
5653217 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
Protein SPTL-1
Protein Entry
SPTC1_CAEEL
UniProt ID
P91079
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2).
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Function Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen. {ECO:0000250, ECO:0000269|PubMed:21926990}.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subunit Heterodimer of sptl-1/sptl-2 or sptl-1/sptl-3. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007848 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71982617 RefSeq NP_001021978 458 Protein SPTL-1, isoform a
71982625 RefSeq NP_001021979 434 Protein SPTL-1, isoform b

Identical Sequences to LMP007848 proteins

Reference Database Accession Length Protein Name
GI:71982617 EMBL CCD65323.1 458 Protein SPTL-1, isoform a [Caenorhabditis elegans]
GI:71982625 EMBL CCD65324.1 434 Protein SPTL-1, isoform b [Caenorhabditis elegans]
GI:71982625 GenBank AGU20652.1 434 Sequence 37 from patent US 8519225
GI:71982617 SwissProt P91079.1 458 RecName: Full=Serine palmitoyltransferase 1; AltName: Full=Long chain base biosynthesis protein 1; Short=LCB 1; AltName: Full=Serine-palmitoyl-CoA transferase 1; Short=SPT 1; Short=SPT1 [Caenorhabditis elegans]

Related Sequences to LMP007848 proteins

Reference Database Accession Length Protein Name
GI:71982617 EMBL CAP27344.1 451 Protein CBR-SPTL-1, partial [Caenorhabditis briggsae]
GI:71982625 EMBL CAP27344.1 451 Protein CBR-SPTL-1, partial [Caenorhabditis briggsae]
GI:71982625 EMBL CCD65323.1 458 Protein SPTL-1, isoform a [Caenorhabditis elegans]
GI:71982617 EMBL CCD65324.1 434 Protein SPTL-1, isoform b [Caenorhabditis elegans]
GI:71982625 GenBank ADY43486.1 474 Serine palmitoyltransferase 1 [Ascaris suum]
GI:71982617 GenBank ADY43486.1 474 Serine palmitoyltransferase 1 [Ascaris suum]
GI:71982617 GenBank AGU20652.1 434 Sequence 37 from patent US 8519225
GI:71982625 RefSeq NP_001021978.1 458 Protein SPTL-1, isoform a [Caenorhabditis elegans]
GI:71982617 RefSeq NP_001021979.1 434 Protein SPTL-1, isoform b [Caenorhabditis elegans]
GI:71982625 RefSeq XP_002632140.1 451 C. briggsae CBR-SPTL-1 protein, partial [Caenorhabditis briggsae]
GI:71982617 RefSeq XP_002632140.1 451 C. briggsae CBR-SPTL-1 protein, partial [Caenorhabditis briggsae]
GI:71982625 SwissProt P91079.1 458 RecName: Full=Serine palmitoyltransferase 1; AltName: Full=Long chain base biosynthesis protein 1; Short=LCB 1; AltName: Full=Serine-palmitoyl-CoA transferase 1; Short=SPT 1; Short=SPT1 [Caenorhabditis elegans]