Gene/Proteome Database (LMPD)

LMPD ID
LMP007865
Gene ID
176716
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein Y39E4A.3
Gene Symbol
Y39E4A.3
Synonyms
CELE_Y39E4A.3
Alternate Names
Protein Y39E4A.3
Chromosome
III
EC Number
1.2.4.4

Proteins

Protein Y39E4A.3, isoform a
Refseq ID NP_001033376
Protein GI 86563355
UniProt ID O45924
mRNA ID NM_001038287
Length 431
RefSeq Status REVIEWED
MHRALLNASRRVATVRSMASTVEGDAFRLSEYSSKYLGHRKAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTMENFMNQCYGNADDLGKGRQMPMHFGTKERNFVTISSPLTTQLPQAVGSAYAFKQQKDNNRIAVVYFGDGAASEGDAHAAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGKGPAYGLHTIRVDGNDLLAVYNATKEARRVALTNRPVLIEAMTYRLGHHSTSDDSTAYRSSDEVQTWGDKDHPITRFKKYITERGWWNEEKEMEWQKEVKKRVLTEFAAAEKRKKAHYHDLFEDVYDELPLRLRRQRDELDAHVAEYKEHYPMLETLQSKP
Protein Y39E4A.3, isoform b
Refseq ID NP_001033377
Protein GI 86563357
UniProt ID O45924
mRNA ID NM_001038288
Length 432
RefSeq Status REVIEWED
MMHRALLNASRRVATVRSMASTVEGDAFRLSEYSSKYLGHRKAAFTEKLEIVNADDTPALPIYRVTNAVGDVIDKSQDPNFDEQTSLKMYKTMTQLNIMDRILYDSQRQGRISFYMTSFGEEGNHVGSAAALEPQDLIYGQYREAGVLLWRGYTMENFMNQCYGNADDLGKGRQMPMHFGTKERNFVTISSPLTTQLPQAVGSAYAFKQQKDNNRIAVVYFGDGAASEGDAHAAFNFAATLKCPIIFFCRNNGYAISTPTSEQYGGDGIAGKGPAYGLHTIRVDGNDLLAVYNATKEARRVALTNRPVLIEAMTYRLGHHSTSDDSTAYRSSDEVQTWGDKDHPITRFKKYITERGWWNEEKEMEWQKEVKKRVLTEFAAAEKRKKAHYHDLFEDVYDELPLRLRRQRDELDAHVAEYKEHYPMLETLQSKP

Gene Information

Entrez Gene ID
176716
Gene Name
Protein Y39E4A.3
Gene Symbol
Y39E4A.3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0003863 IEA:UniProtKB-EC F 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
cel01100 Metabolic pathways
cel00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5652523 Branched-chain amino acid catabolism
5652513 Metabolism of amino acids and derivatives

Domain Information

InterPro Annotations

Accession Description
IPR001017 Dehydrogenase, E1 component
IPR029061 Thiamin diphosphate-binding fold

UniProt Annotations

Entry Information

Gene Name
Protein Y39E4A.3
Protein Entry
ODBA_CAEEL
UniProt ID
O45924
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2- methylpropanoyl)transferase] S-(2- methylpropanoyl)dihydrolipoyllysine + CO(2). {ECO:0000269|PubMed:15340492}.
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
Function The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). {ECO:0000250, ECO:0000269|PubMed:15340492}.
Pathway Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:15340492}.
Similarity Belongs to the BCKDHA family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007865 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
86563355 RefSeq NP_001033376 431 Protein Y39E4A.3, isoform a
86563357 RefSeq NP_001033377 432 Protein Y39E4A.3, isoform b

Identical Sequences to LMP007865 proteins

Reference Database Accession Length Protein Name
GI:86563355 EMBL CAA16329.2 431 Protein Y39E4A.3, isoform a [Caenorhabditis elegans]
GI:86563357 EMBL CAJ21557.1 432 Protein Y39E4A.3, isoform b [Caenorhabditis elegans]
GI:86563355 SwissProt O45924.2 431 RecName: Full=2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; AltName: Full=Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007865 proteins

Reference Database Accession Length Protein Name
GI:86563357 EMBL CAA16329.2 431 Protein Y39E4A.3, isoform a [Caenorhabditis elegans]
GI:86563355 EMBL CAJ21557.1 432 Protein Y39E4A.3, isoform b [Caenorhabditis elegans]
GI:86563357 GenBank ABZ31972.1 478 Sequence 5910 from patent US 7314974
GI:86563355 GenBank ABZ31972.1 478 Sequence 5910 from patent US 7314974
GI:86563357 GenBank EFO83650.1 432 hypothetical protein CRE_03031 [Caenorhabditis remanei]
GI:86563355 GenBank EFO83650.1 432 hypothetical protein CRE_03031 [Caenorhabditis remanei]
GI:86563355 GenBank EGT36804.1 430 hypothetical protein CAEBREN_05328 [Caenorhabditis brenneri]
GI:86563357 RefSeq NP_001033376.1 431 Protein Y39E4A.3, isoform a [Caenorhabditis elegans]
GI:86563355 RefSeq NP_001033377.1 432 Protein Y39E4A.3, isoform b [Caenorhabditis elegans]
GI:86563357 RefSeq XP_003111789.1 432 hypothetical protein CRE_03031 [Caenorhabditis remanei]
GI:86563355 RefSeq XP_003111789.1 432 hypothetical protein CRE_03031 [Caenorhabditis remanei]
GI:86563357 SwissProt O45924.2 431 RecName: Full=2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; AltName: Full=Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; Flags: Precursor [Caenorhabditis elegans]