Gene/Proteome Database (LMPD)

LMPD ID
LMP007873
Gene ID
178387
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein DLD-1
Gene Symbol
dld-1
Synonyms
CELE_LLC1.3
Alternate Names
Protein DLD-1
Chromosome
IV
EC Number
1.8.1.4

Proteins

Protein DLD-1, isoform a
Refseq ID NP_001255810
Protein GI 392901817
UniProt ID O17953
mRNA ID NM_001268881
Length 495
RefSeq Status REVIEWED
MSLSRTTQLPFAKRQFFQVLARNYSNTQDADLVVIGGGPGGYVAAIKAAQLGMKTVCVEKNATLGGTCLNVGCIPSKALLNNSHYLHMAQHDFAARGIDCTASLNLPKMMEAKSNSVKQLTGGIKQLFKANKVGHVEGFATIVGPNTVQAKKNDGSVETINARNILIASGSEVTPFPGITIDEKQIVSSTGALSLGQVPKKMVVIGAGVIGLELGSVWQRLGAEVTAVEFLGHVGGMGIDGEVSKNFQRSLTKQGFKFLLNTKVMGASQNGSTITVEVEGAKDGKKQTLECDTLLVSVGRRPYTEGLGLSNVQIDLDNRGRVPVNERFQTKVPSIFAIGDVIEGPMLAHKAEDEGILCVEGIAGGPVHIDYNCVPSVVYTHPEVAWVGKAEEQLKQEGVAYKIGKFPFVANSRAKTNNDQEGFVKVLADKQTDRMLGVHIIGPNAGEMIAEATLAMEYGASAEDVARVCHPHPTLSEAFREANLAAYCGKAINNV
Protein DLD-1, isoform b
Refseq ID NP_001255811
Protein GI 392901819
UniProt ID O17953
mRNA ID NM_001268882
Length 150
RefSeq Status REVIEWED
MLAHKAEDEGILCVEGIAGGPVHIDYNCVPSVVYTHPEVAWVGKAEEQLKQEGVAYKIGKFPFVANSRAKTNNDQEGFVKVLADKQTDRMLGVHIIGPNAGEMIAEATLAMEYGASAEDVARVCHPHPTLSEAFREANLAAYCGKAINNV

Gene Information

Entrez Gene ID
178387
Gene Name
Protein DLD-1
Gene Symbol
dld-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0004148 IEA:UniProtKB-EC F dihydrolipoyl dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0045454 IEA:InterPro P cell redox homeostasis
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
cel00020 Citrate cycle (TCA cycle)
cel_M00009 Citrate cycle (TCA cycle, Krebs cycle)
cel00260 Glycine, serine and threonine metabolism
cel00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR006258 Dihydrolipoamide dehydrogenase
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

UniProt Annotations

Entry Information

Gene Name
Protein DLD-1
Protein Entry
DLDH_CAEEL
UniProt ID
O17953
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=a; IsoId=O17953-1; Sequence=Displayed; Name=b; IsoId=O17953-2; Sequence=VSP_045381;
Catalytic Activity Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
Miscellaneous The active site is a redox-active disulfide bond. {ECO:0000250}.
Similarity Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007873 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392901817 RefSeq NP_001255810 495 Protein DLD-1, isoform a
392901819 RefSeq NP_001255811 150 Protein DLD-1, isoform b

Identical Sequences to LMP007873 proteins

Reference Database Accession Length Protein Name
GI:392901817 EMBL CAB05249.2 495 Protein DLD-1, isoform a [Caenorhabditis elegans]
GI:392901819 EMBL CBK19462.1 150 Protein DLD-1, isoform b [Caenorhabditis elegans]
GI:392901817 GenBank AGU20779.1 495 Sequence 164 from patent US 8519225
GI:392901817 SwissProt O17953.2 495 RecName: Full=Dihydrolipoyl dehydrogenase, mitochondrial; AltName: Full=Dihydrolipoamide dehydrogenase; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007873 proteins

Reference Database Accession Length Protein Name
GI:392901819 EMBL CAB05249.2 495 Protein DLD-1, isoform a [Caenorhabditis elegans]
GI:392901817 EMBL CAP38335.2 495 Protein CBR-DLD-1 [Caenorhabditis briggsae]
GI:392901817 GenBank ABZ32286.1 464 Sequence 6224 from patent US 7314974
GI:392901819 GenBank EFO88408.1 495 hypothetical protein CRE_11384 [Caenorhabditis remanei]
GI:392901817 GenBank EFO88408.1 495 hypothetical protein CRE_11384 [Caenorhabditis remanei]
GI:392901817 GenBank EGT53974.1 495 hypothetical protein CAEBREN_01666 [Caenorhabditis brenneri]
GI:392901819 GenBank AGU20779.1 495 Sequence 164 from patent US 8519225
GI:392901817 RefSeq XP_002632654.1 464 Hypothetical protein CBG21577 [Caenorhabditis briggsae]
GI:392901819 RefSeq XP_003095799.1 495 hypothetical protein CRE_11384 [Caenorhabditis remanei]
GI:392901817 RefSeq XP_003095799.1 495 hypothetical protein CRE_11384 [Caenorhabditis remanei]
GI:392901819 RefSeq NP_001255810.1 495 Protein DLD-1, isoform a [Caenorhabditis elegans]
GI:392901819 SwissProt O17953.2 495 RecName: Full=Dihydrolipoyl dehydrogenase, mitochondrial; AltName: Full=Dihydrolipoamide dehydrogenase; Flags: Precursor [Caenorhabditis elegans]