Gene/Proteome Database (LMPD)

LMPD ID
LMP007883
Gene ID
179945
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein DLAT-1
Gene Symbol
dlat-1
Synonyms
CELE_F23B12.5
Chromosome
V

Proteins

Protein DLAT-1
Refseq ID NP_506579
Protein GI 17560088
UniProt ID Q19749
mRNA ID NM_074178
Length 507
RefSeq Status REVIEWED
MSKFPVPLRTIGGLRPSTTAAISAANIGFTQSSRALSTGAAAKSSGLVGQVARQYPNAAAFSIKQVRLYSSGNLPKHNRVALPALSPTMELGTVVSWQKKEGDQLSEGDLLCEIETDKATMGFETPEEGYLAKILIQEGSKDVPIGKLLCIIVDNEADVAAFKDFKDDGASSGGSAPAAEKAPEPAKPAASSQPSPPAQMYQAPSVPKSAPIPHSSSGRVSASPFAKKLAAENGLDLSGVSGSGPGGRILASDLSQAPAKGATSTTTQAVSGQDYTDIPLSNMRKTIAKRLTESKSTIPHYYLTSEIQLDTLLQVREKLNGLLAKGTSGQATKISINDFIIKASALACQRVPEANSYWMDSFIRENHHVDVSVAVSTPAGLITPIIFNAHAKGLATIASEIVELAQRAREGKLQPHEFQGGTFTVSNLGMFGSVSDFTAIINPPQSCILAIGGASDKLVPDEAEGYKKIKTMKVTLSCDHRTVDGAVGAVWLRHFKEFLEKPHTMLL

Gene Information

Entrez Gene ID
179945
Gene Name
Protein DLAT-1
Gene Symbol
dlat-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0045254 IEA:InterPro C pyruvate dehydrogenase complex
GO:0004742 IEA:UniProtKB-EC F dihydrolipoyllysine-residue acetyltransferase activity
GO:0006096 IEA:UniProtKB-KW P glycolytic process

Domain Information

InterPro Annotations

Accession Description
IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR000089 Biotin/lipoyl attachment
IPR023213 Chloramphenicol acetyltransferase-like domain
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR004167 E3-binding domain
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
Protein DLAT-1
Protein Entry
Q19749_CAEEL
UniProt ID
Q19749
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
Cofactor Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence= ; Note=Binds 1 lipoyl cofactor covalently. ;
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Similarity Belongs to the 2-oxoacid dehydrogenase family.
Similarity Contains 1 lipoyl-binding domain.
Subcellular Location Mitochondrion matrix .

Identical and Related Proteins

Unique RefSeq proteins for LMP007883 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17560088 RefSeq NP_506579 507 Protein DLAT-1

Identical Sequences to LMP007883 proteins

Reference Database Accession Length Protein Name
GI:17560088 EMBL CAB01163.1 507 Protein DLAT-1 [Caenorhabditis elegans]
GI:17560088 GenBank ABZ32660.1 507 Sequence 6598 from patent US 7314974
GI:17560088 SwissProt Q19749.1 507 RecName: Full=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; AltName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; AltName: Full=Pyruvate dehydrogenase complex component E2; Short=PDC-E2; Short=PDCE2; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007883 proteins

Reference Database Accession Length Protein Name
GI:17560088 EMBL CAP25282.1 507 Protein CBR-DLAT-1 [Caenorhabditis briggsae]
GI:17560088 GenBank EFP11194.1 507 hypothetical protein CRE_30653 [Caenorhabditis remanei]
GI:17560088 GenBank EGT39242.1 507 hypothetical protein CAEBREN_15446 [Caenorhabditis brenneri]
GI:17560088 RefSeq XP_002637823.1 507 Hypothetical protein CBG04612 [Caenorhabditis briggsae]
GI:17560088 RefSeq XP_003112673.1 507 hypothetical protein CRE_30653 [Caenorhabditis remanei]
GI:17560088 RefSeq XP_003112821.1 508 hypothetical protein CRE_30652 [Caenorhabditis remanei]