Gene/Proteome Database (LMPD)

LMPD ID
LMP007899
Gene ID
181790
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein CGT-2
Gene Symbol
cgt-2
Synonyms
CELE_F20B4.6
Chromosome
X
EC Number
2.4.1.80;

Proteins

Protein CGT-2
Refseq ID NP_510857
Protein GI 25147526
UniProt ID G5EC84
mRNA ID NM_078456
Length 443
MGDKITGLEVEIIPEISEVQPESLQEQNASSLYYPLFSQYIPLLLTGTKKILEDIDYCTCFAVFGVVFVSALYFLHIVGLCYGKYRLHRPTKPNPSLPGVSIIKPIIGADANLYTNLETFFTTQYHKFELLFCFDRSDDPAVKVVESLVKKYPSVDSTMFFGGEKIGLNPKINNMMPAYRIAKYQLIMISDSGIFMKSDAVLDMASTMMSHETMALVTQTPYCKDRKGFASVFEQIYFGTSHARIYLAGNCLQFNCPTGMSSMMKKEALDECGGFAAFSGYLAEDYFFGKKLASRGYKSGISTHPALQNSAAVTMTSFTDRVCRWVKLRMAMMPQIIFVEPLQDCFPSALIISFSLNYIANIDMLTTIMLHVVFWITMDCMVMCKMQNKKMSFSPLKFLLIWLLRELFAPLVFIKAALDPSIRWRDNVFHLAWGGKIRSQTSI

Gene Information

Entrez Gene ID
181790
Gene Name
Protein CGT-2
Gene Symbol
cgt-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008120 IEA:UniProtKB-EC F ceramide glucosyltransferase activity
GO:0006665 IEA:UniProtKB-UniPathway P sphingolipid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5653416 Glycosphingolipid metabolism
5652491 Metabolism
5652530 Metabolism of lipids and lipoproteins
5653217 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025993 Ceramide glucosyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
Protein CGT-2
Protein Entry
CGT2_CAEEL
UniProt ID
G5EC84
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity UDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. {ECO:0000269|PubMed:11443131, ECO:0000269|PubMed:21325339}.
Disruption Phenotype Reduced brood size
Disruption Phenotype Reduced brood size. {ECO:0000269|PubMed:21325339}.
Function Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. {ECO:0000269|PubMed:11443131, ECO:0000269|PubMed:21325339}.
Pathway Lipid metabolism; sphingolipid metabolism
Pathway Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:11443131, ECO:0000269|PubMed:21325339}.
Similarity Belongs to the glycosyltransferase 2 family
Similarity Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular Location Membrane ; Multi-pass membrane protein .
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007899 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25147526 RefSeq NP_510857 443 Protein CGT-2

Identical Sequences to LMP007899 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP007899 proteins

Reference Database Accession Length Protein Name