Gene/Proteome Database (LMPD)

LMPD ID
LMP007916
Gene ID
172167
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein LET-363
Gene Symbol
let-363
Synonyms
CELE_B0261.2
Alternate Names
Protein LET-363
Chromosome
I
EC Number
2.7.11.1

Proteins

Protein LET-363, isoform a
Refseq ID NP_491549
Protein GI 32563905
UniProt ID Q95Q95
mRNA ID NM_059148
Length 2695
RefSeq Status REVIEWED
MLQQHGISFQMNADRQNKAATTSNRIVSAPATNEFDERHRKQGIDAARALASQYRSRITENRDANQRQAARELSRYVRSELKDEPNTFSDAFLNAIDGRTDIASQSAIYNCMKSNSNIDQKRAGIYLIVCLAETHSGNVIRYANYLLKMLNNGNGLDEDTVKMASKALAFLIATCKSYAAELVDRCLDHCHEWLGQNVPHSQQPKNQQEIDQIRRLAASHLSRELALATPTAFFLRVNLFFKYIFNAVRDKNPAVRIAGIDALHVVLTIVSQREAKNKTEWFKKCFDEALEGQPNPSQKDDLDRWHAVALILNELLRISDQRFELIRCESSQFIKQKFLKEDEEEGVEWLVLTKQQTIVESVTARKLVLERFPKILDCVRQIIPLANKTSSTKQQSSIYLNTVLMQLLPRICAFPQCDRTFQTISFDTSFTILQRNAVAAPAIGMMMLSNPDVHATHIEKTISFISAAIKKTTNSDVLDNYFTFLFLFVDAYHEQVTTQIKAIIPQLMDITLSRSLANVLKMIMMRIPKLRLNVQDGVMASVYQTLTGSLIPPKSEPIGRPASPKAILQKAETDPKELQRIVLAVDVLGEFYFSRGALQRIMQYVADYYLTADNVEIRLAAVSSCCEMVVPFVGVYKKVTSDKRNSLLQTIYGVLRAVCSVIVNDQDVRVRMQVISCFGQMPRPFLAHLAQPEMLEVQFMALHDEKLEMQQACVTLLGRLAELNPALVLPRLRLMLLETLSQMQQSGQARLEQHSAKMIAQLAKQSPKFMRPYVGSLMIAMIPKLRNDQKYAEVTAQVLNAVSEIAVIGGAEIVKNLKPLFEKLTHMINDSSSLHKREAALRAIGGICRSTAYVVDPYRDYPSLLDDLLRILKTVMSNTMRREAIKTLGILGAIDPYTHKVFTGSVQSSTAISTALSLPISETDSKDPRQDIIHWFNYEKCTLEEFYPAITIANLMLMMQDEDSQSYAEIAQAIVTIFRSLGDMAPLYTEQVIPRLIEVCRRATESSNRANLREFFLQQLANFVAIIRKHAAPYMPAIFTIIADAWKEDISVKMVVIEVLTDMGTAIGNDFSKYTGELIPYLLTVLQTDKTKERVLTVKVMESIQKLTHCIVQHLHLVLPPLLIILDDFSLKLSIRNTALSTVLHMTQQVDVSAYAPRMMQSWHHNISTAEMRDKLLLLLIEIIKQLGKFFDIFKRGVDQKLRDYNLDKSVHYEQYRKLAQRAQMSRDVLTSSVFAGSNGNIQYSSTQAGMRGQANNVYANNDLHERLMNGSIDSGASRQDNRDDYYRYGVEEKISEEVPKVAPTTARPTSELVTVQITKQRLNKDALMPQWKNENLTSKDEWLQWLMKIRIGFLTYGSSPSLRAASSLGDQHPHLARDLFPAAFMSVWTELDSDVQNDLTSCLLRAISTGIPELIQTILNLAEFMDHSEKGPLPISHDVLGRWAEQTKAFAKACRYKEMSVLKKSGSMQTTFTRKVKLEPNDCQSLITYANKLNVQEEAAGVVRYAERNEMNFQMRGRWYEKLNEWEKALGAYELEEKKKSSCPNLQVYDEKDHLMTPEEAATAEEARMHEMRCLEALGRWDELNSKSVVWADQRGNRNDSVRDEINKKQLDHKMAVIAARGAWAVDNWERMADYVSVISENTQDGAMLRAVVAVHNDENTKAMGLIEKVREMIDSELTAMANESYERAYIPMVSVQQMAELEEAIEYKTRPERRPRIALLWSRRLQGCRRNVEQWQRLIMLRGLVLSPQEMHPLRVKFSSMCRKQGKNSMSRAVLRELLSLPANSDLVRAKAPFDKPLLVLALAKQLYQDDHKDEAIRALEDLANHWNKRINPIPKATGRELIPPSTKEPARICAKVLLKLGEWTELKSKTSNNMQVGELSFVRQQVSPQYRTKESRTPETIAFENTINYYQQATQYDPGWHKVWHKLASTHFYAVCRERPHPTTVISPPQQPQQPKKMHIPPVTRATSPPPPAQKSPQPAPFHSITEPLSVIIDYPVPPPLGSLVGLPPMPAYLSSNSSLPPQHHHVSPLSNDSPSNSAENKLYLKHAAHAVRCFAKALMCSPGSRLEDTLRLMQLWFDHGDDKDQDVYFALTETIFDLPVTTWLEAIPQLMARLDCPDDQKSVQLVLRVLCEIARHRPQAVIYALTVASRSKDVHRSKNAGTVLEKMMEYHSKLVREASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAMFDALRNMNDLMQKGAPTTMKEHSFQQTYSSDLKEAGRYVQAFESSGNVKDLNQAWEIYCSVFKKLRDQLATLNSLDLVYVSPNLVSAKDLELVVPGTYDPSAPIVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKDTGGRQNMAGAVLPSSSTTDSIMETIKRKLDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSPLNLCQSYIGWCPFW
Protein LET-363, isoform b
Refseq ID NP_491552
Protein GI 32563909
UniProt ID Q95Q95
mRNA ID NM_059151
Length 2692
RefSeq Status REVIEWED
MLQQHGISFQMNADRQNKAATTSNRIVSAPATNEFDERHRKQGIDAARALASQYRSRITENRDANQRQAARELSRYVRSELKDEPNTFSDAFLNAIDGRTDIASQSAIYNCMKSNSNIDQKRAGIYLIVCLAETHSGNVIRYANYLLKMLNNGNGLDEDTVKMASKALAFLIATCKSYAAELVDRCLDHCHEWLGQNVPHSQQPKNQQEIDQIRRLAASHLSRELALATPTAFFLRVNLFFKYIFNAVRDKNPAVRIAGIDALHVVLTIVSQREAKNKTEWFKKCFDEALEGQPNPSQKDDLDRWHAVALILNELLRISDQRFELIRCESSQFIKQKFLKEDEEEGVEWLVLTKQQTIVESVTARKLVLERFPKILDCVRQIIPLANKTSSTKQQSSIYLNTVLMQLLPRICAFPQCDRTFQTISFDTSFTILQRNAVAAPAIGMMMLSNPDVHATHIEKTISFISAAIKKTTNSDVLDNYFTFLFLFVDAYHEQVTTQIKAIIPQLMDITLSRSLANVLKMIMMRIPKLRLNVQDGVMASVYQTLTGSLIPPKSEPIGRPASPKAILQKAETDPKELQRIVLAVDVLGEFYFSRGALQRIMQYVADYYLTADNVEIRLAAVSSCCEMVVPFVGVYKKVTSDKRNSLLQTIYGVLRAVCSVIVNDQDVRVRMQVISCFGQMPRPFLAHLAQPEMLEVQFMALHDEKLEMQQACVTLLGRLAELNPALVLPRLRLMLLETLSQMQQSGQARLEQHSAKMIAQLAKQSPKFMRPYVGSLMIAMIPKLRNDQKYAEVTAQVLNAVSEIAVIGGAEIVKNLKPLFEKLTHMINDSSSLHKREAALRAIGGICRSTAYVVDPYRDYPSLLDDLLRILKTVMSNTMRREAIKTLGILGAIDPYTHKVFTGSVQSSTAISTALSLPISETDSKDPRQDIIHWFNYEKCTLEEFYPAITIANLMLMMQDEDSQSYAEIAQAIVTIFRSLGDMAPLYTEQVIPRLIEVCRRATESSNRANLREFFLQQLANFVAIIRKHAAPYMPAIFTIIADAWKEDISVKMVVIEVLTDMGTAIGNDFSKYTGELIPYLLTVLQTDKTKERVLTVKVMESIQKLTHCIVQHLHLVLPPLLIILDDFSLKLSIRNTALSTVLHMTQQVDVSAYAPRMMQSWHHNISTAEMRDKLLLLLIEIIKQLGKFFDIFKRGVDQKLRDYNLDKSVHYEQYRKLAQRAQMSRDVLTSSVFAGSNGNIQYSSTQAGMRGQANNVYANNDLHERLMNGSIDSGASRQDNRDDYYRYGVEEKISEEVPKVAPTTARPTSELVTVQITKQRLNKDALMPQWKNENLTSKDEWLQWLMKIRIGFLTYGSSPSLRAASSLGDQHPHLARDLFPAAFMSVWTELDSDVQNDLTSCLLRAISTGIPELIQTILNLAEFMDHSEKGPLPISHDVLGRWAEQTKAFAKACRYKEMSVLKKSGSMQTTFTRKVKLEPNDCQSLITYANKLNVQEEAAGVVRYAERNEMNFQMRGRWYEKLNEWEKALGAYELEEKKKSSCPNLQVYDEKDHLMTPEEAATAEEARMHEMRCLEALGRWDELNSKSVVWADQRGNRNDSVRDEINKKQLDHKMAVIAARGAWAVDNWERMADYVSVISENTQDGAMLRAVVAVHNDENTKAMGLIEKVREMIDSELTAMANESYERAYIPMVSVQQMAELEEAIEYKTRPERRPRIALLWSRRLQGCRRNVEQWQRLIMLRGLVLSPQEMHPLRVKFSSMCRKQGKNSMSRAVLRELLSLPANSDLVRAKAPFDKPLLVLALAKQLYQDDHKDEAIRALEDLANHWNKRINPIPKATGRELIPPSTKEPARICAKVLLKLGEWTELKSKTSNNMQVGELSFVRQQVSPQYRTKESRTPETIAFENTINYYQQATQYDPGWHKVWHKLASTHFYAVCRERPHPTTVISPPQQPQQPKKMHIPPVTRATSPPPPAQKSPQPAPFHSITEPLSDYPVPPPLGSLVGLPPMPAYLSSNSSLPPQHHHVSPLSNDSPSNSAENKLYLKHAAHAVRCFAKALMCSPGSRLEDTLRLMQLWFDHGDDKDQDVYFALTETIFDLPVTTWLEAIPQLMARLDCPDDQKSVQLVLRVLCEIARHRPQAVIYALTVASRSKDVHRSKNAGTVLEKMMEYHSKLVREASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAMFDALRNMNDLMQKGAPTTMKEHSFQQTYSSDLKEAGRYVQAFESSGNVKDLNQAWEIYCSVFKKLRDQLATLNSLDLVYVSPNLVSAKDLELVVPGTYDPSAPIVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKDTGGRQNMAGAVLPSSSTTDSIMETIKRKLDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSPLNLCQSYIGWCPFW

Gene Information

Entrez Gene ID
172167
Gene Name
Protein LET-363
Gene Symbol
let-363
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:WormBase C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0031931 ISS:WormBase C TORC1 complex
GO:0031932 ISS:WormBase C TORC2 complex
GO:0016303 ISS:WormBase F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0008144 IEA:InterPro F drug binding
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity
GO:0000492 IMP:WormBase P box C/D snoRNP assembly
GO:0008340 IGI:WormBase P determination of adult lifespan
GO:0002119 IMP:WormBase P nematode larval development
GO:0036092 ISS:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0046854 ISS:WormBase P phosphatidylinositol phosphorylation
GO:0045727 IMP:WormBase P positive regulation of translation
GO:0006417 IMP:WormBase P regulation of translation
GO:0031929 IMP:WormBase P TOR signaling

KEGG Pathway Links

KEGG Pathway ID Description
cel04012 ErbB signaling pathway
ko04012 ErbB signaling pathway
cel04150 mTOR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR024585 Domain of unknown function DUF3385, target of rapamycin protein
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR014009 PIK-related kinase
IPR003151 PIK-related kinase, FAT
IPR003152 PIK-related kinase, FATC
IPR011009 Protein kinase-like domain
IPR009076 Rapamycin-binding domain

UniProt Annotations

Entry Information

Gene Name
Protein LET-363
Protein Entry
TOR_CAEEL
UniProt ID
Q95Q95
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=a; IsoId=Q95Q95-1; Sequence=Displayed; Name=b; IsoId=Q95Q95-2; Sequence=VSP_009223;
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Disruption Phenotype Defects strongly increase lifespan, the mean lifetime being of 25 days instead of 10 days, suggesting that it may be involved in aging process. {ECO:0000269|PubMed:14668850}.
Function Kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May act as a mediator of lifespan regulation by insulin signaling and nutrient sensing. {ECO:0000269|PubMed:12225660, ECO:0000269|PubMed:14668850}.
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000305}.
Similarity Contains 1 FATC domain. {ECO:0000255|PROSITE- ProRule:PRU00535}.
Similarity Contains 1 FAT domain. {ECO:0000255|PROSITE- ProRule:PRU00534}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 7 HEAT repeats. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12225660}.
Tissue Specificity Ubiquitous. Expressed in all major tissues and organs, including the intestine, gonads and hypodermal cells. {ECO:0000269|PubMed:12225660}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007916 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32563905 RefSeq NP_491549 2695 Protein LET-363, isoform a
32563909 RefSeq NP_491552 2692 Protein LET-363, isoform b

Identical Sequences to LMP007916 proteins

Reference Database Accession Length Protein Name
GI:32563905 EMBL CCD61569.1 2695 Protein LET-363, isoform a [Caenorhabditis elegans]
GI:32563909 EMBL CCD61570.1 2692 Protein LET-363, isoform b [Caenorhabditis elegans]

Related Sequences to LMP007916 proteins

Reference Database Accession Length Protein Name
GI:32563909 EMBL CCD61569.1 2695 Protein LET-363, isoform a [Caenorhabditis elegans]
GI:32563905 EMBL CCD61570.1 2692 Protein LET-363, isoform b [Caenorhabditis elegans]
GI:32563909 GenBank ABZ31098.1 2697 Sequence 5036 from patent US 7314974
GI:32563905 GenBank ABZ31098.1 2697 Sequence 5036 from patent US 7314974
GI:32563905 PIR - 2697 hypothetical protein B0261.2 - Caenorhabditis elegans [Caenorhabditis elegans]
GI:32563909 PIR - 2697 hypothetical protein B0261.2 - Caenorhabditis elegans [Caenorhabditis elegans]
GI:32563909 RefSeq NP_491549.2 2695 Protein LET-363, isoform a [Caenorhabditis elegans]
GI:32563905 RefSeq NP_491552.2 2692 Protein LET-363, isoform b [Caenorhabditis elegans]
GI:32563905 RefSeq XP_003114766.1 2743 CRE-LET-363 protein [Caenorhabditis remanei]
GI:32563909 RefSeq XP_003114766.1 2743 CRE-LET-363 protein [Caenorhabditis remanei]
GI:32563909 SwissProt Q95Q95.3 2697 RecName: Full=Target of rapamycin homolog; AltName: Full=CeTOR; AltName: Full=Lethal protein 363 [Caenorhabditis elegans]
GI:32563905 SwissProt Q95Q95.3 2697 RecName: Full=Target of rapamycin homolog; AltName: Full=CeTOR; AltName: Full=Lethal protein 363 [Caenorhabditis elegans]