Gene/Proteome Database (LMPD)

LMPD ID
LMP007923
Gene ID
172520
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein LRP-1
Gene Symbol
lrp-1
Synonyms
CELE_F29D11.1
Alternate Names
Protein LRP-1
Chromosome
I

Proteins

Protein LRP-1
Refseq ID NP_492127
Protein GI 17508271
UniProt ID Q04833
mRNA ID NM_059726
Length 4753
RefSeq Status REVIEWED
MILRLLIFTALAVTTANSSTRQQSTFHSIQVDSPPSVRSRIISASVNTASSVCNENDFRCNDGKCIRTEWKCDGSGDCSDGEDEKDCPHPGCKSDQWQCDTYTWHSVSCIAEYQRCDNITDCADGSDEKDCPASTVDCSSQNVFMCADGRQCFDVSKKCDGKYDCRDLSDEKDSCSRNHTACFQYQFRCADKTQCIQKSWVCDGSKDCADGSDEPDTCEFKKCTANEFQCKNKRCQPRKFRCDYYDDCGDNSDEDECGEYRCPPGKWNCPGTGHCIDQLKLCDGSKDCADGADEQQCSQNLCPSLGCQAGCHPSPHGGECTCPSGYKLDDRFHRTCSDINECAEFGYCDQLCANHRPGFTCSCLGDCFTLQMEHGPGKDNLTMRGYCVSNNADKMKLFVARREGLYRLNPKNPDEEVKKLASGEFIYGIDFDYGDRKIFWTDRLAHSAFSADVDDEGEISQIKKLSLKSLVYPRCLAVDWITNTLYIIESGSRRIDVSSYDGERRTVLLADGLTLPLDIALDPLRGEMFFTNQLKLEAAAMDGTNRRTLVNTHTHQVSGIVVDITAKRVYWVDPKVDRLESIDYQGNDRRIVAQGMNVVPHPFGLALFDQYLYWTDWTRLGVIQVEKFGSDTKLLWSNTENNVFPMGISAYHPMAQPGPGQSECLAMKIENPCTNADCEGMCILSKDNGGFGVGYKCACPIGQKLVNGKRCIDSIDYLLFSSNKIVRGIFPEINEKALAEAVLPISPISQRRIGMYFEVECDVHGNSFFYADIMDNTIYRIRPDGEGAAPVLVTHNDGLFSMSFDWISKQLYYVDNIRNSLEVVKIGETGLVHPDELVRRQLITELRDPVSVVVHPWKGLLFYAEAMRPAAIYRCHIDGQNCQVIRNTTLGRPSEMAIDFAENRLCWGDTLLKTISCMDFDGKNVVKLDIDNPIPVAITIMNEYIYYVHQRPYSIRRVHKKNGGGSKIVREFGADERSIFSLKACSHQNQPIPDDSREHPCRASQCTQLCFATPSESHPNELEAKCACRQGFMINKENNHSCQKDPAEKIEQLCSSNSTQFQCKNGRCIPKEWKCDGENDCLDESDEIDEKGDKCFHETECAENTIKCRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKPVCAAKKFQCDNHRCIPEQWKCDSDNDCGDGSDEKLEMCGNATCAANQFSCANGRCIPIYWLCDGDNDCYDGTDEDKERCPPVQCSALQFRCANGRQCVPLRNHCDGQSDCEDGSDEDSCAVTAESCTPDQFKCVSSGLCIPASWKCDGQQDCDDGSDEPKFGCTSGRQCSSDQFKCGNGRCILNNWLCDGENDCGDGSDESSERGCKTSMNARKCPFEHVACENDQETCIPLHQLCDGKTHCPGGTDEGGRCARDLCSADRAGCSFKCHNSPNGPICSCPFGEQLVNKTKCEPENECLDSSSCSQRCKDEKHGFTCSCDEGYELDVDKRTCKVADNVKDTRIYVSNRNRIYYSDHKLDNWHTFGAIVENAIALAWDSLTDRIYWSDIREKKILSANRNGTNATVFIADGLDITEGIALDWVGRNLYWVDSSLNTIEVANLEDPKQRTLLVHQNVSQPRGIAVDPRKGVMFWTDWGQNPCIERASMDGTDRQIIVKTKIYWPNTIALDYTTDRVYFADSKLDFIDFVNYDGSGRTQVLASSKFVQHPHALAIFEDMMYYSDRRLQKLQVYPKYPNGTTSEYPSHTFSKALGVVAVHPVLQPVIKNNPCSTNPCSHLCLLNNKNTFTCKCPMGEKLDASGKKCIDDAKPFLVIIQKTNVFGIEMNSASEKETPVLAGMVPLSGLGNAFDAAYDALSEEMFILEHTNHAKTLAQITTDSAIYRSTVNGGNKTKMFSSAVPDDAYCLGFDWNGRNLVVGNKITQTIEIIRTQGKQYRSVILSNDQSPTAVVTPVAIAVDADKGYVFWLDRGGGAADAKVARAGLDGSNPLVIASNDLAELDHIAIDTTNTRVYFSEAKAGRISSVTYDGQDRHYVLSDGGRQPNGLAFYGDRLFYADSAFDSIEVATINGDSQPPQWTHFKKDVENLANIKALQPRASSSGHPCHINNGNCDHICIPLMFAQRTCTCANGYVKDGQTSCKLFDESFVIVATKTKVIGYPIDETQSKGVAMEPIGGLSITGVDYDYESKTIYVAEASGINKGITAYTIGESSPRAVIRDSIGSLTIKSLAIDWINYNMYFINHDAERTNIEVSKLDGTYRKILLTTKTETPSSIAVDPVSRYLYWADQGQKPTIQRSFLDGSRREVIVSSGIAEPTDLVVDVASKMIYWSDAKMDGIYRVRSTGGTPELVRSDIASAAGVALHGQNMYWTDNRLEKLFRATSKPNQTSLLLSPTTVAASLKDIGDVAVFSSNNQPRASSPCQITDNLRKSPCTQLCFATPGTQTPTCSCARGVLKGRTCEEPDTYIMFSDGDKIIDVAIEPDVKASRPLKDPFPEISNLQTFDVDVNLRRVYFVVESPVGVNISWFSMNNAENPRLVFGASKQPHAKEIRHISDMKLDWLTQKIYFTTGRGGKVMAIDTAGEHLSTIASGDWTYALAIDPCSGLLFWSDSGYKTSGGLYEPRIERSNLAGGSRKVIVSESISLPAAIAVDFRNQKIYWADVNRLNIEVADYDGQNRKVIASGYRAKSLDIWDRWLYMSDPLSNGVFRIDKESGSGLENVVSDRRIPGALRVFASESDVRTRNQVCNALTSQLCKTDNGGCDQLCTVVADDIGLAASKVQCSCNDTYELVQEPGKDYPTQCVLRGSNSEPAKECLPPYNFQCGDGSCILLGATCDSKPDCADASDENPNYCNTRSCPEDYNLCTNRRCIDSAKKCNHIDDCGDGSDELDCPSAVACAEGTFPCSNGHCINQTKVCDGHNDCHDEQVSDESLATCPGLPIDCRGVKVRCPNTNICIQPADLCDGYDDCGDKADENQLFCMNQQCAQHYVRCPSGRCIPETWQCDGDNDCSDGWDETHTNCTDTAGKKICVGDYLFQCDNLKCISRAFICDGEDDCGDGSDEHSRHGCGNRTCTDQEFHCTSNAKLAQPKYECIPRAWLCDGDVTCAGGEDESTELCKTEKKECNKGEFRCSNQHCIHSTWECDGDNDCLDGSDEHANCTYSSCQPDFFQCANHKCVPNSWKCDGNDDCEDGSDEKDCPKNSASAQKASKCSNGQFQCTSGECIDDAKVCDRNFDCTDRSDESSLCFIDECSLAEKPLCEQKCMDMKIGYKCDCFEGFAIDISDQKSCHNVNECYEGISGCSQKCDDKIGSYKCGCVDGYQLSSDDHSCKRTEMEPEPFFLLANKHYIRKISIDGNKYELAAQGFDNVVSLDIDLTEKKAYLIDQGKLRLLRVDLDEMDSPLSSYETVLRHNVYGTEGIAVDWVGRKLYMLNRQERSIRVCELDGRFCKTLIRDRIQQPKAIVVHPGKGYLFFTEWSLQPYIGRIALDGSPELQDPIFKLAEHDLGWPNAIAIDYFSDRLFWGDAHLNEIGFMDFDGNGRRHIPAQRTSHVSSMVVFDDYLYWADWNLREVLRCDKWTGKNETILKKTVQLPNDLRIVHPMRQPAYPNPCGDNNGGCSHLCLIGAGGNGYTCSCPDQFVLLSDQKTCEPNCTERQFACGGDDAKCIPKLWYCDGEPDCRDGSDEPGESICGQRICPVGEFQCTNHNCTRPFQICDGNDDCGDSSDEQNCDKACDPWMFKCAATGRCIPRRFTCDGDDDCGDRSDEADTLCMSAERNCTAEEFRCNNNKCIAKAWRCDNDDDCGDGSDETPECAQIECKKGWTRCSSSYRCIPNWAFCNGQDDCRDNSDEDKQRCPTCDDVGEFRCATSGKCIPRRWMCDTENDCGDNSDELDASCGGTTRPCSESEFRCNDGKCIPGSKVCDGTIQCSDGLDESQCTLRRCLPGHRQCDDGTCIAEHKWCDRKKDCPNAADELHCEDVSRRTCSPFEFECANSVCIPRKFMCDGDNDCGDNSDETSSECRSAQCDPPLRFRCAHSRLCLNILQLCNGFNDCGPNDFSDEHLSMCSSFSEYGDCSSDQFKCANGKCVNGTVACDRKDDCGDASDEIGCSKHGGKTSCEAFGNNGGCKHICTDVRDGFYCHCRDGFRPDPQSPKECIDIDECAGNNTCTQLCLNTKGSYLCRCHEDYENNVVVGSMTGKDCRAKGDAANVMIGADDSLVQLSLHGSGTNRHAAAKANDDDNDIIGIAFDPRKELMYWIDGSERTIYRSAIANGNQSHEGQKLDVDFAAMGVVPTAIAVDYTTGNLFIAAVSENIENGLVTARKKRMSEPIDNQNTGFIFVCLPDGRYLKKIVAGHLQQPTALITAPSAGRICYSDAGLHAKIECADMDGTHRQIIVKDLVFSPTSMAIDEGKGNRIYWVDPKYRRVDAVNIDGSERTTVVHDRHIPYAVDVFENHIYWLSRESKTLYVQDKFGRGRVSVLASDLEDGHTVRVSQKYAKDTQRTVSGCERAQCSHLCVSLPSTGFACLCPDGIVPQLDGSCATQHVEALTMPKQCKCTNGGKCRLDGSCECTSDFEGDQCEKESSVSRKIIGTLSENFITVLLYILAFLFAFGLIGFCALNLYKRRQLLFKKNEAADGSVSFHGNVISFSNPVLENKQDAPGSEFNMQQMTSMHDDSTTFTNPVYELEDVDMSSPPPSNDQPSTSASAMSPNRPSTSAASSFVPPTFDQDEIELKTADEIIVPKAEISKPPIPARPKKEKADPLRVDNPLYDPDSEVSDV

Gene Information

Entrez Gene ID
172520
Gene Name
Protein LRP-1
Gene Symbol
lrp-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016324 IDA:WormBase C apical plasma membrane
GO:0005905 IEA:UniProtKB-KW C coated pit
GO:0030139 IDA:WormBase C endocytic vesicle
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0015248 IMP:WormBase F sterol transporter activity
GO:0042395 IMP:WormBase P ecdysis, collagen and cuticulin-based cuticle
GO:0006897 IEA:UniProtKB-KW P endocytosis
GO:0002119 IMP:WormBase P nematode larval development
GO:0040017 IMP:WormBase P positive regulation of locomotion
GO:0040018 IMP:WormBase P positive regulation of multicellular organism growth
GO:0030334 IGI:WormBase P regulation of cell migration
GO:0015918 IMP:WormBase P sterol transport

KEGG Pathway Links

KEGG Pathway ID Description
cel04340 Hedgehog signaling pathway
ko04340 Hedgehog signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001881 EGF-like calcium-binding domain
IPR018097 EGF-like calcium-binding, conserved site
IPR013032 EGF-like, conserved site
IPR000742 Epidermal growth factor-like domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR000033 LDLR class B repeat
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
IPR011042 Six-bladed beta-propeller, TolB-like

UniProt Annotations

Entry Information

Gene Name
Protein LRP-1
Protein Entry
LRP_CAEEL
UniProt ID
Q04833
Species
C. elegans

Comments

Comment Type Description
Function May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease- inhibitor complexes and vitellogenin.
Similarity Belongs to the LDLR family. {ECO:0000305}.
Similarity Contains 17 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Similarity Contains 30 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
Similarity Contains 35 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}.
Subcellular Location Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Identical and Related Proteins

Unique RefSeq proteins for LMP007923 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17508271 RefSeq NP_492127 4753 Protein LRP-1

Identical Sequences to LMP007923 proteins

Reference Database Accession Length Protein Name
GI:17508271 EMBL CAA98124.1 4753 Protein LRP-1 [Caenorhabditis elegans]
GI:17508271 GenBank AAA28105.1 4753 LDL receptor-related protein [Caenorhabditis elegans]
GI:17508271 GenBank ABZ31181.1 4753 Sequence 5119 from patent US 7314974
GI:17508271 GenBank AGU20862.1 4753 Sequence 247 from patent US 8519225
GI:17508271 SwissProt Q04833.1 4753 RecName: Full=Low-density lipoprotein receptor-related protein; Short=LRP; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP007923 proteins

Reference Database Accession Length Protein Name
GI:17508271 EMBL CAP30953.2 4829 Protein CBR-LRP-1 [Caenorhabditis briggsae]
GI:17508271 GenBank EFO92853.1 4438 CRE-LRP-1 protein [Caenorhabditis remanei]
GI:17508271 GenBank EGT42186.1 4402 hypothetical protein CAEBREN_28281 [Caenorhabditis brenneri]
GI:17508271 GenBank EGT57713.1 4759 CBN-LRP-1 protein [Caenorhabditis brenneri]
GI:17508271 RefSeq XP_002638687.1 4759 Hypothetical protein CBG11882 [Caenorhabditis briggsae]
GI:17508271 RefSeq XP_003093860.1 4438 CRE-LRP-1 protein [Caenorhabditis remanei]