Gene/Proteome Database (LMPD)

LMPD ID
LMP007943
Gene ID
174001
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein CGT-3
Gene Symbol
cgt-3
Synonyms
CELE_F59G1.1
Alternate Names
Protein CGT-3
Chromosome
II
EC Number
2.4.1.80

Proteins

Protein CGT-3, isoform a
Refseq ID NP_495182
Protein GI 25149574
UniProt ID Q21054
mRNA ID NM_062781
Length 459
RefSeq Status REVIEWED
MCKYGKSNLAAVASSTSSIIGAAAAAVAEAQPSASPSTSSSFLLLEVPFRHLLRLQPPPYFIAGTRRMAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQDCFPSGLIMAFSLNHLVGLNIMPILILHTIYWFSMDYSLMNSMQNGKLSFSPLQFMLIWLLRELTAPFVFIKALLQPTIQWRNNVFHLAWGGQILPPKC
Protein CGT-3, isoform b
Refseq ID NP_495181
Protein GI 25149577
UniProt ID Q21054
mRNA ID NM_062780
Length 470
RefSeq Status REVIEWED
MEVAKAVATNLSTAANSTVLRTVASSTSSIIGAAAAAVAEAQPSASPSTSSSFLLLEVPFRHLLRLQPPPYFIAGTRRMAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQDCFPSGLIMAFSLNHLVGLNIMPILILHTIYWFSMDYSLMNSMQNGKLSFSPLQFMLIWLLRELTAPFVFIKALLQPTIQWRNNVFHLAWGGQILPPKC
Protein CGT-3, isoform c
Refseq ID NP_741005
Protein GI 25149580
UniProt ID Q21054
mRNA ID NM_171006
Length 379
RefSeq Status REVIEWED
MEVAKAVATNLSTAANSTVLRTVASSTSSIIGAAAAAVAEAQPSASPSTSSSFLLLEVPFRHLLRLQPPPYFIAGTRRMAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQVIPKFTFF
Protein CGT-3, isoform d
Refseq ID NP_871996
Protein GI 32564728
UniProt ID Q21054
mRNA ID NM_182196
Length 392
RefSeq Status REVIEWED
MAAQLDVTTLIAIVGFVFVFCLYLIHIIALSYSKYRLHHKVKEDSSLPGVSIIKPIVGKDNNLYENIESFFTTQYHKYELLFCFNSSDDEAVEVVKCLMKKYPKVDAKLFFGGETVGLNPKINNMMPAYRSALYPLILVSDSGIFMRSDGVLDMATTMMSHEKMALVTQTPYCKDREGFDAAFEQMYFGTSHGRIYLAGNCMDFVCSTGMSSMMKKEALDECGGISNFGGYLAEDYFFGRELANRGYKSAISSHPALQNSSSVSVSSFLDRICRWVKLRIAMLPHILLVEPLQDCFPSGLIMAFSLNHLVGLNIMPILILHTIYWFSMDYSLMNSMQNGKLSFSPLQFMLIWLLRELTAPFVFIKALLQPTIQWRNNVFHLAWGGQILPPKC

Gene Information

Entrez Gene ID
174001
Gene Name
Protein CGT-3
Gene Symbol
cgt-3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:WormBase C plasma membrane
GO:0008120 IEA:UniProtKB-EC F ceramide glucosyltransferase activity
GO:0006665 IEA:UniProtKB-UniPathway P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
cel01100 Metabolic pathways
cel00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5653416 Glycosphingolipid metabolism
5653217 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025993 Ceramide glucosyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
Protein CGT-3
Protein Entry
CGT3_CAEEL
UniProt ID
Q21054
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=a; IsoId=Q21054-1; Sequence=Displayed; Name=b; IsoId=Q21054-2; Sequence=VSP_045384; Name=c; IsoId=Q21054-3; Sequence=VSP_045384, VSP_045385, VSP_045386; Name=d; IsoId=Q21054-4; Sequence=VSP_045383;
Catalytic Activity UDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. {ECO:0000269|PubMed:21325339}.
Disruption Phenotype Reduced brood size. Reduced glucosyl- ceramide content and expression at cell surface. Increased expression of sphingomyelins and sphingomyelin clustering at cell surface. Loss of function in the germline leads to defects in oocyte formation and early embryonic divisions and shortened body length. Loss of function in somatic cells may lead to L1 arrest. {ECO:0000269|PubMed:21325339}.
Function Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Seems to be the major active form in the nematode. {ECO:0000269|PubMed:21325339}.
Pathway Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:21325339}.
Similarity Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007943 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25149574 RefSeq NP_495182 459 Protein CGT-3, isoform a
25149577 RefSeq NP_495181 470 Protein CGT-3, isoform b
25149580 RefSeq NP_741005 379 Protein CGT-3, isoform c
32564728 RefSeq NP_871996 392 Protein CGT-3, isoform d

Identical Sequences to LMP007943 proteins

Reference Database Accession Length Protein Name
GI:25149574 EMBL CCD70149.1 459 Protein CGT-3, isoform a [Caenorhabditis elegans]
GI:25149577 EMBL CCD70150.1 470 Protein CGT-3, isoform b [Caenorhabditis elegans]
GI:25149580 EMBL CCD70151.1 379 Protein CGT-3, isoform c [Caenorhabditis elegans]
GI:32564728 EMBL CCD70152.1 392 Protein CGT-3, isoform d [Caenorhabditis elegans]
GI:32564728 GenBank ABD75711.1 392 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149577 GenBank ABD75712.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149577 GenBank ABD75713.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149574 SwissProt Q21054.2 459 RecName: Full=Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

Related Sequences to LMP007943 proteins

Reference Database Accession Length Protein Name
GI:25149577 EMBL CCD70149.1 459 Protein CGT-3, isoform a [Caenorhabditis elegans]
GI:32564728 EMBL CCD70149.1 459 Protein CGT-3, isoform a [Caenorhabditis elegans]
GI:25149574 EMBL CCD70150.1 470 Protein CGT-3, isoform b [Caenorhabditis elegans]
GI:25149580 EMBL CCD70150.1 470 Protein CGT-3, isoform b [Caenorhabditis elegans]
GI:25149580 GenBank ABD75712.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149574 GenBank ABD75712.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:32564728 GenBank ABD75712.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:32564728 GenBank ABD75713.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149580 GenBank ABD75713.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149574 GenBank ABD75713.1 470 ceramide glycosyl transferase [Caenorhabditis elegans]
GI:25149574 GenBank EGT48373.1 470 CBN-CGT-3 protein [Caenorhabditis brenneri]
GI:25149577 GenBank EGT48373.1 470 CBN-CGT-3 protein [Caenorhabditis brenneri]
GI:25149574 PIR - 511 hypothetical protein F59G1.1 - Caenorhabditis elegans [Caenorhabditis elegans]
GI:25149577 PIR - 511 hypothetical protein F59G1.1 - Caenorhabditis elegans [Caenorhabditis elegans]
GI:25149580 PIR - 511 hypothetical protein F59G1.1 - Caenorhabditis elegans [Caenorhabditis elegans]
GI:32564728 RefSeq NP_495182.2 459 Protein CGT-3, isoform a [Caenorhabditis elegans]
GI:25149580 RefSeq NP_495182.2 459 Protein CGT-3, isoform a [Caenorhabditis elegans]
GI:25149577 RefSeq NP_495182.2 459 Protein CGT-3, isoform a [Caenorhabditis elegans]
GI:25149574 RefSeq NP_495181.2 470 Protein CGT-3, isoform b [Caenorhabditis elegans]
GI:25149580 RefSeq NP_495181.2 470 Protein CGT-3, isoform b [Caenorhabditis elegans]
GI:32564728 RefSeq NP_495181.2 470 Protein CGT-3, isoform b [Caenorhabditis elegans]
GI:25149577 RefSeq XP_003113883.1 470 CRE-CGT-3 protein [Caenorhabditis remanei]
GI:25149577 SwissProt Q21054.2 459 RecName: Full=Ceramide glucosyltransferase 3 [Caenorhabditis elegans]
GI:32564728 SwissProt Q21054.2 459 RecName: Full=Ceramide glucosyltransferase 3 [Caenorhabditis elegans]