Gene/Proteome Database (LMPD)

LMPD ID
LMP007952
Gene ID
174542
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein C08H9.3
Gene Symbol
CELE_C08H9.3
Synonyms
CELE_C08H9.3
Alternate Names
Protein C08H9.3
Chromosome
II
EC Number
2.4.1.265

Proteins

Protein C08H9.3, isoform a
Refseq ID NP_001021940
Protein GI 392891338
UniProt ID P52887
mRNA ID NM_001026769
Length 766
RefSeq Status REVIEWED
MGEVQLVLAVTAILISFKCLLIPAYVSTDFEVHRNWMAVTWQRPLCEWYTEATSEWTLDYPPFFAYFELGLASVAHFFGFDECLVISKTPRFSRRILIFQRFSVIFCDILYIAVCALYSFRSPRLVSRIPKKLQQNGREACFVLLASLQALIICDSIHFQYNSMLTAIFLMSLFFIDTERYLMAALSYSILLNFKHIYVYYALGYVFYYLVNYFQFSGNVLLANTPKAISLAIALLIPFCASIFPFIHASGVQGLQNIATRLFPVSRGLTHAYWAPNFWALYNFADLCLYRVLSLLKIGKFDAPTYTSGLVQEYSHSVLPNVSPMGTLCLVVISSMIVLTGLVIRRKDSADFSLFAVFSAFCFFYFGYHVHEKAIILVTVPMTVFAIKNPKYHSILIHLTCIASFSLFPLLFTPFETLLKYAICVSYFFIQLVFLKRVTLMPLSDLIPTRHVASWLLMGMVEVYNTFLHKWLWTSRLPFAPLMAISILTAIELTGLIGALIWSTFGDGIFEIWWAKATCQIRERLIRDSTYSVQAVEDLDDVKLVAGIDTSAAKLNSDMVYISVSFWTYPDLKHVATISDTRMLELPYIPQYLAVREAEVMADFLKSVITERPELRPDVILCDGFGEFHSRGCGMACHVGALSGIASIGVAKNLTLHHTYETIGMENKSKVDSFVEHCREVYKNNKTSPGFIPFDIVEPVVLNILRMGSSMNGVFVSAGYGIDLELSTEICSQLLLNNTTIEPIRAADLESRRLVRENFDGNEKLE
Protein C08H9.3, isoform b
Refseq ID NP_001021941
Protein GI 71981515
UniProt ID P52887
mRNA ID NM_001026770
Length 123
RefSeq Status REVIEWED
MGEVQLVLAVTAILISFKCLLIPAYVSTDFEVHRNWMAVTWQRPLCEWYTEATSEWTLDYPPFFAYFELGLASVAHFFGFDECLVISKTPRFSRRILIFQRFSVIFCDILLLSALYTPSALHV

Gene Information

Entrez Gene ID
174542
Gene Name
Protein C08H9.3
Gene Symbol
CELE_C08H9.3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004519 IEA:InterPro F endonuclease activity
GO:0016758 IEA:InterPro F transferase activity, transferring hexosyl groups
GO:0006281 IEA:InterPro P DNA repair
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5652982 Asparagine N-linked glycosylation
5652981 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5652580 Metabolism of proteins
5652867 Post-translational protein modification

Domain Information

InterPro Annotations

Accession Description
IPR021173 Bifunctional dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase/endonuclease V
IPR007581 Endonuclease V
IPR004856 Glycosyl transferase, ALG6/ALG8

UniProt Annotations

Entry Information

Gene Name
Protein C08H9.3
Protein Entry
ALG8_CAEEL
UniProt ID
P52887
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=a; IsoId=P52887-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=b; IsoId=P52887-2; Sequence=VSP_012307, VSP_012308; Note=No experimental confirmation available.;
Catalytic Activity Dolichyl beta-D-glucosyl phosphate + D-Glc- alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha- (1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)- D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha- (1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D- Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man- alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta- (1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
Function Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). {ECO:0000250}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the ALG6/ALG8 glucosyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP007952 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
392891338 RefSeq NP_001021940 766 Protein C08H9.3, isoform a
71981515 RefSeq NP_001021941 123 Protein C08H9.3, isoform b

Identical Sequences to LMP007952 proteins

Reference Database Accession Length Protein Name
GI:71981515 EMBL CAH60747.1 123 Protein C08H9.3, isoform b [Caenorhabditis elegans]
GI:392891338 EMBL CAA91145.3 766 Protein C08H9.3, isoform a [Caenorhabditis elegans]
GI:392891338 SwissProt P52887.3 766 RecName: Full=Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 8 homolog; AltName: Full=Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase; AltName: Full=Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase [Caenorhabditis elegans]

Related Sequences to LMP007952 proteins

Reference Database Accession Length Protein Name
GI:392891338 EMBL CAP22260.2 821 Protein CBG00995 [Caenorhabditis briggsae]
GI:71981515 EMBL CAP22260.2 821 Protein CBG00995 [Caenorhabditis briggsae]
GI:71981515 EMBL CAA91145.3 766 Protein C08H9.3, isoform a [Caenorhabditis elegans]
GI:392891338 EMBL CDJ98447.1 767 Glycosyltransferase and Endonuclease V domain containing protein [Haemonchus contortus]
GI:71981515 GenBank EFP13118.1 439 hypothetical protein CRE_07703 [Caenorhabditis remanei]
GI:392891338 GenBank EFP13118.1 439 hypothetical protein CRE_07703 [Caenorhabditis remanei]
GI:392891338 GenBank EGT34974.1 691 hypothetical protein CAEBREN_21094 [Caenorhabditis brenneri]
GI:392891338 RefSeq XP_002629759.1 690 Hypothetical protein CBG00995 [Caenorhabditis briggsae]
GI:392891338 RefSeq XP_003098317.1 439 hypothetical protein CRE_07703 [Caenorhabditis remanei]
GI:71981515 RefSeq XP_003098317.1 439 hypothetical protein CRE_07703 [Caenorhabditis remanei]
GI:71981515 RefSeq NP_001021940.2 766 Protein C08H9.3, isoform a [Caenorhabditis elegans]
GI:71981515 SwissProt P52887.3 766 RecName: Full=Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; AltName: Full=Asparagine-linked glycosylation protein 8 homolog; AltName: Full=Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase; AltName: Full=Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase [Caenorhabditis elegans]