Gene/Proteome Database (LMPD)
Proteins
| Protein MMCM-1 | |
|---|---|
| Refseq ID | NP_497786 |
| Protein GI | 25144500 |
| UniProt ID | Q23381 |
| mRNA ID | NM_065385 |
| Length | 744 |
| RefSeq Status | REVIEWED |
| MYLQLLKPTLLRCSTRPSSSGAYTRSPIDQKWAAMAKKAMKGREADTLTWNTPEGIPIKPLYLRSDRDCDAQRSVELPGQFPFTRGPYPTMYTQRPWTIRQYAGFSTVEESNKFYKENIKAGQQGLSVAFDLATHRGYDSDNPRVFGDVGMAGVAVDSVEDMRQLFDGINLEKMSVSMTMNGAVVPVLAMYVVAAEEAGVSRKLLAGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIFAYTSREMPKFNSISISGYHMQEAGADAVLEMAFTIADGIQYCETGLNAGLTIDAFAPRLSFFWGISMNFYMEIAKMRAARRLWANLIKERFSPKSDKSMMLRTHSQTSGWSLTEQDPYNNIIRTTIEAMASVFGGTQSLHTNSFDEALGLPTKFSARIARNTQIIIQEESGICNVADPWGGSYMMESLTDEIYEKALAVIKEIDELGGMAKAVASGMTKLKIEEAAAKKQARIDAGKDVIVGVNKYRLDHEQQVEVLKIDNAKVREEQCAKLNHIRATRDAEKAQKALDAITEGARGNGNLMELAIEAARARCTVGEISDAMEKVFNRHAAVNRLVSGAYKSEFGETSEMSQVLERVKSFADRDGRQPRIMVAKMGQDGHDRGAKVIATGFADLGFDVDVGPLFQTPLEAAQQAVDADVHVIGASSLAAGHLTLIPQLIGELKKLGRPDILVVAGGVIPPQDYKELYDAGVALVFGPGTRLPACANQILEKLEANLPEAPGKAASR | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IDA:WormBase | C | mitochondrion |
| GO:0031419 | IEA:UniProtKB-KW | F | cobalamin binding |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0004494 | IEA:UniProtKB-EC | F | methylmalonyl-CoA mutase activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| cel01200 | Carbon metabolism |
| cel00630 | Glyoxylate and dicarboxylate metabolism |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR006158 | Cobalamin (vitamin B12)-binding domain |
| IPR016176 | Cobalamin (vitamin B12)-dependent enzyme, catalytic |
| IPR014348 | Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain |
| IPR006159 | Methylmalonyl-CoA mutase, C-terminal |
| IPR006098 | Methylmalonyl-CoA mutase, alpha chain, catalytic |
| IPR006099 | Methylmalonyl-CoA mutase, alpha/beta chain, catalytic |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (R)-methylmalonyl-CoA = succinyl-CoA. |
| Cofactor | Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408; Evidence={ECO:0000250}; |
| Function | Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the methylmalonyl-CoA mutase family. {ECO:0000305}. |
| Similarity | Contains 1 B12-binding domain. {ECO:0000255|PROSITE- ProRule:PRU00666}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000250}. |
| Subunit | Homodimer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP007963 (as displayed in Record Overview)
Identical Sequences to LMP007963 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:25144500 | EMBL | CAA84676.2 | 744 | Protein MMCM-1 [Caenorhabditis elegans] |
| GI:25144500 | SwissProt | Q23381.2 | 744 | RecName: Full=Probable methylmalonyl-CoA mutase, mitochondrial; AltName: Full=MethylmalonylCoA mutase homolog 1; Short=MCM; Flags: Precursor [Caenorhabditis elegans] |
Related Sequences to LMP007963 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:25144500 | EMBL | CAP24468.2 | 751 | Protein CBR-MMCM-1 [Caenorhabditis briggsae] |
| GI:25144500 | EMBL | CDJ88170.1 | 745 | Methylmalonyl-CoA mutase and Cobalamin (vitamin B12)-binding domain containing protein [Haemonchus contortus] |
| GI:25144500 | GenBank | EGT45828.1 | 744 | hypothetical protein CAEBREN_23569 [Caenorhabditis brenneri] |
| GI:25144500 | GenBank | EYC24963.1 | 783 | hypothetical protein Y032_0012g1610 [Ancylostoma ceylanicum] |
| GI:25144500 | GenBank | EYC24964.1 | 777 | hypothetical protein Y032_0012g1610 [Ancylostoma ceylanicum] |
| GI:25144500 | RefSeq | XP_002647077.1 | 742 | C. briggsae CBR-MMCM-1 protein [Caenorhabditis briggsae] |