Gene/Proteome Database (LMPD)

LMPD ID
LMP008025
Gene ID
179962
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein GAR-3
Gene Symbol
gar-3
Synonyms
CELE_Y40H4A.1
Chromosome
V

Proteins

Protein GAR-3, isoform a
Refseq ID NP_001024235
Protein GI 72001135
UniProt ID Q9U7D5
mRNA ID NM_001029064
Length 585
RefSeq Status REVIEWED
MQSSSLGNADDPRFRQTHLFQMLVKVINTSAENATKTAIATSSTSTPSFVDTYSTSSLLGEEGRMVMIVVIGAMFALVTSLGNLMVMVSFKIDKQLQTISNYFLFSLAVADIAIGVISIPMFTYYTAIQKWDLGYTMCQFWLCIDYLMSNASVLNLLLISFDRYFSVTRPLSYRPRRTTKKALTMIACTYIISLILWPPWIISWPYIEGKFTAEPGTCVVQFLQTNPYVTVGTAVAAFYLPVTIMCILYTRVYWETQKRQKEFGKLQATQFSRRSMKRDVSSTSIIKSSGSMRKKNNQDGYVEDSVTPCTSSRNSKRKSWLRNCTGKSNSSSEDSSEAVAMNLDDTSLSSSHFALSGSRRRNISPPCTPMPTNFEDEEQTDAGASMRNGSARFRSRPSDTGKNNNSDTYTVLIELNDEGSRPSVRLSSCEPYLDEPISTRNRSKSDCNSEIDERRHSLLNKQSPFKNGRILKNFSSQERKSEKEQRKNERKQESKAAKTLSAILCAFIATWTPYNLIVCWEAFFPNTVPNVLWTFSYFLCYINSTINPLCYALCNARFRHTYMRILRCKFKAERPTMNQGYVRRN
Protein GAR-3, isoform b
Refseq ID NP_001024236
Protein GI 72001137
UniProt ID Q9U7D5
mRNA ID NM_001029065
Length 611
RefSeq Status REVIEWED
MQSSSLGNADDPRFRQTHLFQMLVKVINTSAENATKTAIATSSTSTPSFVDTYSTSSLLGEEGRMVMIVVIGAMFALVTSLGNLMVMVSFKIDKQLQTISNYFLFSLAVADIAIGVISIPMFTYYTAIQKWDLGYTMCQFWLCIDYLMSNASVLNLLLISFDRYFSVTRPLSYRPRRTTKKALTMIACTYIISLILWPPWIISWPYIEGKFTAEPGTCVVQFLQTNPYVTVGTAVAAFYLPVTIMCILYTRVYWETQKRQKEFGKLQATQTWASDVVDRPSTQSFRNSKMWKKVKKFSRRSMKRDVSSTSIIKSSGSMRKKNNQDGYVEDSVTPCTSSRNSKRKSWLRNCTGKSNSSSEDSSEAVAMNLDDTSLSSSHFALSGSRRRNISPPCTPMPTNFEDEEQTDAGASMRNGSARFRSRPSDTGKNNNSDTYTVLIELNDEGSRPSVRLSSCEPYLDEPISTRNRSKSDCNSEIDERRHSLLNKQSPFKNGRILKNFSSQERKSEKEQRKNERKQESKAAKTLSAILCAFIATWTPYNLIVCWEAFFPNTVPNVLWTFSYFLCYINSTINPLCYALCNARFRHTYMRILRCKFKAERPTMNQGYVRRN

Gene Information

Entrez Gene ID
179962
Gene Name
Protein GAR-3
Gene Symbol
gar-3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 IDA:WormBase C integral component of plasma membrane
GO:0016907 IEA:InterPro F G-protein coupled acetylcholine receptor activity
GO:0007213 IMP:WormBase P G-protein coupled acetylcholine receptor signaling pathway
GO:0001508 IMP:WormBase P action potential
GO:0014057 IMP:WormBase P positive regulation of acetylcholine secretion, neurotransmission
GO:0043051 IMP:WormBase P regulation of pharyngeal pumping

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000995 Muscarinic acetylcholine receptor family

UniProt Annotations

Entry Information

Gene Name
Protein GAR-3
Protein Entry
Q9U7D5_CAEEL
UniProt ID
Q9U7D5
Species
C. elegans

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=b; Synonyms=GAR-3a; IsoId=Q9U7D5-1; Sequence=Displayed; Name=a; Synonyms=GAR-3b; IsoId=Q9U7D5-2; Sequence=VSP_012003;
Developmental Stage Isoform a and isoform b are expressed at all developmental stages examined, isoform a is more abundant at embryonic and early larval stages and isoform b at first larval instar.
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:10635059, ECO:0000269|PubMed:12927813}.
Similarity Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. {ECO:0000255|PROSITE- ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP008025 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
72001135 RefSeq NP_001024235 585 Protein GAR-3, isoform a
72001137 RefSeq NP_001024236 611 Protein GAR-3, isoform b

Identical Sequences to LMP008025 proteins

Reference Database Accession Length Protein Name
GI:72001135 EMBL CAA22301.2 585 Protein GAR-3, isoform a [Caenorhabditis elegans]
GI:72001137 EMBL CAE47471.1 611 Protein GAR-3, isoform b [Caenorhabditis elegans]
GI:72001135 GenBank AAD48771.1 585 muscarinic acetylcholine receptor [Caenorhabditis elegans]
GI:72001137 GenBank AAP97492.1 611 muscarinic acetylcholine receptor large isoform [Caenorhabditis elegans]
GI:72001137 SwissProt Q9U7D5.2 611 RecName: Full=Muscarinic acetylcholine receptor gar-3; AltName: Full=G-protein-linked acetylcholine receptor 3 [Caenorhabditis elegans]

Related Sequences to LMP008025 proteins

Reference Database Accession Length Protein Name
GI:72001137 EMBL CAA22301.2 585 Protein GAR-3, isoform a [Caenorhabditis elegans]
GI:72001135 EMBL CAE47471.1 611 Protein GAR-3, isoform b [Caenorhabditis elegans]
GI:72001137 EMBL CAP25255.2 609 Protein CBR-GAR-3 [Caenorhabditis briggsae]
GI:72001135 EMBL CAP25255.2 609 Protein CBR-GAR-3 [Caenorhabditis briggsae]
GI:72001137 GenBank AAD48771.1 585 muscarinic acetylcholine receptor [Caenorhabditis elegans]
GI:72001135 GenBank AAP97492.1 611 muscarinic acetylcholine receptor large isoform [Caenorhabditis elegans]
GI:72001137 GenBank EFP05934.1 629 CRE-GAR-3 protein [Caenorhabditis remanei]
GI:72001137 RefSeq NP_001024235.1 585 Protein GAR-3, isoform a [Caenorhabditis elegans]
GI:72001135 RefSeq NP_001024236.1 611 Protein GAR-3, isoform b [Caenorhabditis elegans]
GI:72001135 RefSeq XP_002637796.1 584 C. briggsae CBR-GAR-3 protein [Caenorhabditis briggsae]
GI:72001137 RefSeq XP_003102315.1 629 CRE-GAR-3 protein [Caenorhabditis remanei]
GI:72001135 SwissProt Q9U7D5.2 611 RecName: Full=Muscarinic acetylcholine receptor gar-3; AltName: Full=G-protein-linked acetylcholine receptor 3 [Caenorhabditis elegans]