Gene/Proteome Database (LMPD)

LMPD ID
LMP008031
Gene ID
180533
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein HEX-1
Gene Symbol
hex-1
Synonyms
CELE_T14F9.3
Alternate Names
Protein HEX-1
Chromosome
X
EC Number
3.2.1.52

Proteins

Protein HEX-1
Refseq ID NP_508409
Protein GI 17569815
UniProt ID Q22492
mRNA ID NM_076008
Length 555
RefSeq Status REVIEWED
MRLLIPILIFALITTAVTWFYGRDDPDRWSVGGVWPLPKKIVYGSKNRTITYDKIGIDLGDKKDCDILLSMADNYMNKWLFPFPVEMKTGGTEDFIITVTVKDECPSGPPVHGASEEYLLRVSLTEAVINAQTVWGALRAMESLSHLVFYDHKSQEYQIRTVEIFDKPRFPVRGIMIDSSRHFLSVNVIKRQLEIMSMNKLNVLHWHLVDSESFPYTSVKFPELHGVGAYSPRHVYSREDIADVIAFARLRGIRVIPEFDLPGHTSSWRGRKGFLTECFDEKGVETFLPNLVDPMNEANFDFISEFLEEVTETFPDQFLHLGGDEVSDYIVECWERNKKIRKFMEEKGFGNDTVLLENYFFEKLYKIVENLKLKRKPIFWQEVFDNNIPDPNAVIHIWKGNTHEEIYEQVKNITSQNFPVIVSACWYLNYIKYGADWRDEIRGTAPSNSRYYYCDPTNFNGTVAQKELVWGGIAAIWGELVDNTNIEARLWPRASAAAERLWSPAEKTQRAEDAWPRMHELRCRLVSRGYRIQPNNNPDYCPFEFDEPPATKTEL

Gene Information

Entrez Gene ID
180533
Gene Name
Protein HEX-1
Gene Symbol
hex-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0004563 IDA:UniProtKB F beta-N-acetylhexosaminidase activity
GO:0015929 IDA:WormBase F hexosaminidase activity
GO:0005975 IDA:UniProtKB P carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
cel00520 Amino sugar and nucleotide sugar metabolism
cel04142 Lysosome

REACTOME Pathway Links

REACTOME Pathway ID Description
5653417 CS/DS degradation
5653416 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029019 Beta-hexosaminidase, eukaryotic type, N-terminal
IPR025705 Beta_hexosaminidase_sua/sub
IPR029018 Chitobiase/beta-hexosaminidase domain 2-like
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase superfamily
IPR013781 Glycoside hydrolase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
Protein HEX-1
Protein Entry
HEXA_CAEEL
UniProt ID
Q22492
Species
C. elegans

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=1.1 mM for p-nitrophenyl-beta-N-acetylglucosaminide {ECO:0000269|PubMed:17636254}; pH dependence: Optimum pH is 5.5. {ECO:0000269|PubMed:17636254};
Catalytic Activity Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides. {ECO:0000269|PubMed:17636254}.
Developmental Stage Expressed throughout the life cycle. {ECO:0000269|PubMed:17636254}.
Disruption Phenotype Worms show reduced degradation of p- nitrophenyl-beta-N-acetylglucosaminide and no chitotriosidase activity. {ECO:0000269|PubMed:17636254}.
Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose. {ECO:0000269|PubMed:17636254}.
Similarity Belongs to the glycosyl hydrolase 20 family. {ECO:0000305}.
Subcellular Location Lysosome {ECO:0000305}.
Tissue Specificity Expressed in coelomocytes and neurons of the pharyngeal region and nerve cord. {ECO:0000269|PubMed:17636254}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008031 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17569815 RefSeq NP_508409 555 Protein HEX-1

Identical Sequences to LMP008031 proteins

Reference Database Accession Length Protein Name
GI:17569815 EMBL CAO72174.1 555 hexosaminidase [Caenorhabditis elegans]
GI:17569815 EMBL CCD68941.1 555 Protein HEX-1 [Caenorhabditis elegans]
GI:17569815 GenBank ABZ32782.1 555 Sequence 6720 from patent US 7314974
GI:17569815 SwissProt Q22492.1 555 RecName: Full=Beta-hexosaminidase A; AltName: Full=Beta-N-acetylhexosaminidase; AltName: Full=N-acetyl-beta-glucosaminidase; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008031 proteins

Reference Database Accession Length Protein Name
GI:17569815 EMBL CAP32722.2 552 Protein CBR-HEX-1 [Caenorhabditis briggsae]
GI:17569815 GenBank EFO83073.1 567 CRE-HEX-1 protein [Caenorhabditis remanei]
GI:17569815 GenBank EYB89966.1 550 hypothetical protein Y032_0225g2761 [Ancylostoma ceylanicum]
GI:17569815 RefSeq XP_002644284.1 557 C. briggsae CBR-HEX-1 protein [Caenorhabditis briggsae]
GI:17569815 RefSeq XP_003118475.1 567 CRE-HEX-1 protein [Caenorhabditis remanei]
GI:17569815 SwissProt Q619W7.2 552 RecName: Full=Beta-hexosaminidase A; AltName: Full=Beta-N-acetylhexosaminidase; AltName: Full=N-acetyl-beta-glucosaminidase; Flags: Precursor [Caenorhabditis briggsae]