Gene/Proteome Database (LMPD)

LMPD ID
LMP008047
Gene ID
181326
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein PGP-3
Gene Symbol
pgp-3
Synonyms
CELE_ZK455.7
Alternate Names
Protein PGP-3
Chromosome
X
EC Number
3.6.3.44

Proteins

Protein PGP-3
Refseq ID NP_509901
Protein GI 17569143
UniProt ID P34713
mRNA ID NM_077500
Length 1268
RefSeq Status REVIEWED
MKKTKVNPEDDITLGKFTPKPSPQDSYQGNFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINMPWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFDETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITVPLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLNEARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGTRRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYPTRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYNIRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSALDTESERMVQTALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIAERGTHDELISKDDGIYASMVKAQEIERAKEDTTLDDEEDEKTHRSFHRDSVTSDEERELQQSLARDSTRLRQSMISTTTQVPEWEIENAREEMIEEGAMEASLFDIFKYASPEMRNIIISLVFTLIRGFTWPAFSIVYGQLFKILSAGGDDVSIKALLNSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSLTSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSSVAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVRGLWQSLSFALAGSFVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAASYFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDTPTIKGNINMRGVYFAYPNRRRQLVLDGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNIALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGASGGRLSGGQKQRVAIARAIVRDPKILLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLLARRGLYYRLVEKQSS

Gene Information

Entrez Gene ID
181326
Gene Name
Protein PGP-3
Gene Symbol
pgp-3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016324 IDA:WormBase C apical plasma membrane
GO:0016021 IBA:RefGenome C integral component of membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042626 IBA:RefGenome F ATPase activity, coupled to transmembrane movement of substances
GO:0008559 IEA:UniProtKB-EC F xenobiotic-transporting ATPase activity
GO:0050829 IGI:WormBase P defense response to Gram-negative bacterium
GO:0045087 IGI:WormBase P innate immune response
GO:0010038 IGI:WormBase P response to metal ion
GO:1990170 IEP:WormBase P stress response to cadmium ion
GO:0055085 IBA:RefGenome P transmembrane transport

KEGG Pathway Links

KEGG Pathway ID Description
cel02010 ABC transporters
ko02010 ABC transporters

REACTOME Pathway Links

REACTOME Pathway ID Description
5653288 PPARA activates gene expression
5653289 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
Protein PGP-3
Protein Entry
PGP3_CAEEL
UniProt ID
P34713
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Function Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency (By similarity). {ECO:0000250}.
Similarity Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
Similarity Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.
Similarity Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
Tissue Specificity Intestinal cells. {ECO:0000269|PubMed:8096815}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008047 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17569143 RefSeq NP_509901 1268 Protein PGP-3

Identical Sequences to LMP008047 proteins

Reference Database Accession Length Protein Name
GI:17569143 EMBL CAA91495.1 1268 Protein PGP-3 [Caenorhabditis elegans]
GI:17569143 GenBank ABZ32976.1 1268 Sequence 6914 from patent US 7314974
GI:17569143 GenBank ABZ32977.1 1268 Sequence 6915 from patent US 7314974
GI:17569143 SwissProt P34713.2 1268 RecName: Full=Multidrug resistance protein pgp-3; AltName: Full=P-glycoprotein C; AltName: Full=P-glycoprotein-related protein 3 [Caenorhabditis elegans]

Related Sequences to LMP008047 proteins

Reference Database Accession Length Protein Name
GI:17569143 EMBL CAA46191.1 1254 P-glycoprotein C [Caenorhabditis elegans]
GI:17569143 EMBL CBJ25073.1 1266 Protein PGP-4, isoform b [Caenorhabditis elegans]
GI:17569143 EMBL CAP35037.2 1298 Protein CBR-PGP-3 [Caenorhabditis briggsae]
GI:17569143 GenBank EFO89819.1 1317 CRE-PGP-3 protein [Caenorhabditis remanei]
GI:17569143 RefSeq XP_002643979.1 1268 C. briggsae CBR-PGP-3 protein [Caenorhabditis briggsae]
GI:17569143 RefSeq XP_003109677.1 1317 CRE-PGP-3 protein [Caenorhabditis remanei]