Gene/Proteome Database (LMPD)
Proteins
| Protein SNF-3 | |
|---|---|
| Refseq ID | NP_493910 |
| Protein GI | 25146584 |
| UniProt ID | G5EBN9 |
| mRNA ID | NM_061509 |
| Length | 600 |
| RefSeq Status | REVIEWED |
| MGTSEHVPLPTDEAKAKELEQSQHSEEPDRGQWTGKFDFLMSMVAYAVGLGNVWRFPYLCYKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQKGAMEMWLMCPLFRGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSIAWVFPWETCNNYWNDATCVTGKENFTELARIKALVASAGGHTQTSVEQFWEKRVLHDTGDISEFGGIQWELFFIMAAAWLIVYFALWKGITQARKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNCFKDAITMCFINGCTSITAGFAVFSILGYMSHVAQKDISEIVKPGVGLAFLAYPEVASNLPMKQVFAVLFFLMITILGLDSQVCMMEGLFTALEDAFPILRKYKKQSLGIFCLFFFCIGIPMVTHSGSHWLTLFDAYGASGYALLFVVFFEVVGLAYGFGAHNIRKALHEMIGVTLPKGIEYVWKFCAPATSLVLFVFCVVYYHPVKYPDGKDFPFWANAFGWFLSSCSMVVIPGYAIYYLFFTNKHLTLKERVRKGLNLDGSFESPAKKNLVNNAEELKFIESSSQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0005328 | IEA:InterPro | F | neurotransmitter:sodium symporter activity |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000175 | Na/ntran_symport |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disruption Phenotype | Mutant worms are morphologically similar to the wild-type but exhibit mild swimming defects and are lethargic when crawling on a food-free environment with their movement being interrupted by frequent pauses. Worms paralyze in the presence of exogenous betaine. Simultaneous knockdown of snf-3 and egl-8 results in uncoordinated, hypercontracted and paralyzed animals. |
| Function | Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space. Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine. |
| Similarity | Belongs to the sodium:neurotransmitter symporter (SNF) family. |
| Subcellular Location | Cell membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Highly expressed in the head, the excretory canal, tail hypodermal cells, epidermis and vulval epithelial cells. Expressed in the excretory canal-associated neuron and in some non-amphidial sensory neurons in the head (at protein level). |
Identical and Related Proteins
Unique RefSeq proteins for LMP008120 (as displayed in Record Overview)
Identical Sequences to LMP008120 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:25146584 | EMBL | CCD63487.1 | 600 | Protein SNF-3 [Caenorhabditis elegans] |
| GI:25146584 | GenBank | AAZ23105.1 | 600 | sodium-coupled betaine transporter protein [Caenorhabditis elegans] |
| GI:25146584 | GenBank | ABF20556.1 | 600 | SNF-3 [Caenorhabditis elegans] |
| GI:25146584 | SwissProt | G5EBN9.1 | 600 | RecName: Full=Sodium- and chloride-dependent betaine transporter; AltName: Full=Betaine transporter SNF-3; AltName: Full=Na(+)/Cl(-) betaine/GABA transporter; AltName: Full=Sodium:neurotransmitter symporter family protein 3 [Caenorhabditis elegans] |
Related Sequences to LMP008120 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:25146584 | EMBL | CAP27175.1 | 599 | Protein CBR-SNF-3 [Caenorhabditis briggsae] |
| GI:25146584 | GenBank | EFO99258.1 | 613 | CRE-SNF-3 protein [Caenorhabditis remanei] |
| GI:25146584 | GenBank | EGT38698.1 | 599 | CBN-SNF-3 protein [Caenorhabditis brenneri] |
| GI:25146584 | GenBank | EYC16738.1 | 799 | hypothetical protein Y032_0032g2465 [Ancylostoma ceylanicum] |
| GI:25146584 | RefSeq | XP_002632310.1 | 599 | C. briggsae CBR-SNF-3 protein [Caenorhabditis briggsae] |
| GI:25146584 | RefSeq | XP_003105850.1 | 613 | CRE-SNF-3 protein [Caenorhabditis remanei] |