Gene/Proteome Database (LMPD)

LMPD ID
LMP008122
Gene ID
173635
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SQV-2
Gene Symbol
sqv-2
Synonyms
CELE_Y110A2AL.14
Alternate Names
Protein SQV-2
Chromosome
II
EC Number
2.4.1.134

Proteins

Protein SQV-2
Refseq ID NP_494394
Protein GI 17537731
UniProt ID Q9N491
mRNA ID NM_061993
Length 330
RefSeq Status REVIEWED
MRFYRTYLLVAGAFCSLCTLAVIFNCGWDDSPPATPSAINGGGSNAPLISSPTNLPETFLYISILTSPNETERRQNVRDTWFRLSTKGPSVFIAKFAVGTMGLAAEDRRLLAEENEKFGDLALLDRHEESYERLAKKTLACFVHAFANFKFKFFLKTDIDSFVRITPLIINLKQIQDPMLYWGFLDGRAKPFRKGKWKEPEWNLCDRYLPYQLGGGYVLSYELIRFLAINAQLFRHYRNEDVSVGAWIGGLDVKYVHDPRFDTEWRSRGCNNEYLITHKHTEQEMQEMFENLKKTGKLCAKEFQKHPSYVYDFSKAPSECCTRVNGSNIP

Gene Information

Entrez Gene ID
173635
Gene Name
Protein SQV-2
Gene Symbol
sqv-2
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:WormBase C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0047220 IDA:WormBase F galactosylxylosylprotein 3-beta-galactosyltransferase activity
GO:0030206 IEA:UniProtKB-UniPathway P chondroitin sulfate biosynthetic process
GO:0009792 IMP:WormBase P embryo development ending in birth or egg hatching
GO:0006024 IDA:WormBase P glycosaminoglycan biosynthetic process
GO:0015012 IEA:UniProtKB-UniPathway P heparan sulfate proteoglycan biosynthetic process
GO:0002009 IMP:WormBase P morphogenesis of an epithelium
GO:0018991 IMP:WormBase P oviposition
GO:0006486 IEA:InterPro P protein glycosylation
GO:0000003 IMP:WormBase P reproduction
GO:0040025 IMP:WormBase P vulval development

KEGG Pathway Links

KEGG Pathway ID Description
cel00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
cel00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
cel_M00057 Glycosaminoglycan biosynthesis, linkage tetrasaccharide

REACTOME Pathway Links

REACTOME Pathway ID Description
5653446 A tetrasaccharide linker sequence is required for GAG synthesis

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
Protein SQV-2
Protein Entry
SQV2_CAEEL
UniProt ID
Q9N491
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity UDP-alpha-D-galactose + 4-beta-D-galactosyl-O- beta-D-xylosyl-[protein] = UDP + 3-beta-D-galactosyl-4-beta-D- galactosyl-O-beta-D-xylosyl-[protein]. {ECO:0000269|PubMed:12584198}.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Disruption Phenotype Worms are infertile because of the failure of the progeny of homozygous mutants to initiate cytokinesis and because of the failure to form an extracellular space between the egg and the eggshell. {ECO:0000269|PubMed:12584198}.
Function Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis. {ECO:0000269|PubMed:12584198}.
Pathway Glycan metabolism; chondroitin sulfate biosynthesis.
Pathway Glycan metabolism; heparan sulfate biosynthesis.
Similarity Belongs to the glycosyltransferase 31 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008122 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17537731 RefSeq NP_494394 330 Protein SQV-2

Identical Sequences to LMP008122 proteins

Reference Database Accession Length Protein Name
GI:17537731 EMBL CCD72980.1 330 Protein SQV-2 [Caenorhabditis elegans]
GI:17537731 GenBank AAO85276.1 330 beta-1,3-galactosyltransferase [Caenorhabditis elegans]
GI:17537731 GenBank ACK12859.1 330 Sequence 10 from patent US 7442501
GI:17537731 SwissProt Q9N491.1 330 RecName: Full=Beta-1,3-galactosyltransferase sqv-2; AltName: Full=Squashed vulva protein 2 [Caenorhabditis elegans]

Related Sequences to LMP008122 proteins

Reference Database Accession Length Protein Name
GI:17537731 EMBL CAJ84707.1 324 beta-1,3-galactosyltransferase 6 [Caenorhabditis briggsae]
GI:17537731 EMBL CAP36830.3 562 Protein CBR-SQV-2 [Caenorhabditis briggsae]
GI:17537731 GenBank EFO88677.1 325 CRE-SQV-2 protein [Caenorhabditis remanei]
GI:17537731 GenBank EGT56471.1 342 hypothetical protein CAEBREN_09023 [Caenorhabditis brenneri]
GI:17537731 RefSeq XP_002646915.1 613 C. briggsae CBR-SQV-2 protein [Caenorhabditis briggsae]
GI:17537731 RefSeq XP_003109888.1 325 CRE-SQV-2 protein [Caenorhabditis remanei]