Gene/Proteome Database (LMPD)

LMPD ID
LMP008139
Gene ID
174287
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein NRF-6
Gene Symbol
nrf-6
Synonyms
CELE_C08B11.4
Alternate Names
Protein NRF-6
Chromosome
II

Proteins

Protein NRF-6
Refseq ID NP_495680
Protein GI 17535341
UniProt ID Q09225
mRNA ID NM_063279
Length 822
RefSeq Status REVIEWED
MGNMRRLLIFAVLVILTVISNSKSSYKYDGSLFSSKELDYDETDTKAMGSVFSRYMSDSDAQLILDLDFFRHFFNYAEAYRDGAEEGNLELMKYAVEMVEKLKSFDISMACVGDMMHLAWTGVEYATHVEEHKNCSDCKCTPLFQQKKSERHWIFNVFDAMGKVPAGIMSGNNLWVGSWSTCRKIDVVKNAQGQKWKGQYCLATIDAYERDNPLVYFGNMMSGPPDKHCYDKTVKNVTDDGFCFALFPVLKFGVCMPNTCTNHDVKQMLSFAIRATEGAVGTKSVCNVDVECRAESYSDAMSENGLAMFALYLLIATVVLVTFGTLYDLFIVSKAPQDEKNSSAFNHPFIKFILAFSMYTNGSEILQSKKNDREINSLHGVRFLSMCWIILGHTYYYIGTSLTTDNLVPTLINFPKQFHTQIIVQAPLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLSAFNWQTWPMYYYKRYIRITPTYIIVMLFDVTLFTYISNGPFWRPIERQGCSIAWWTNLIYLNNFLLQDQECCMGWTWYLANDMQFHIFLMPLLVIVFLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPILTAKLQIVYQLNDYWNDVYVRPYIRCTPFIVGIVVAYLLNAWTTREQKDLKIKLERRTVIICWCTSTVLGLYSVFGLYWFAKTGDISKPWEILYTIFGTPAYALALGWVVFACTTGNGGPVDTILSWRLFVPLSKITFCAYLLHPIMLQIYNLSRPQPFHFTTFIQMIRYTVEAVFASYTIAFFFSLAFEKPLNKIDEMLFNSKKMMNGENGNTTEMVPLNKIRNSD

Gene Information

Entrez Gene ID
174287
Gene Name
Protein NRF-6
Gene Symbol
nrf-6
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0016747 IEA:InterPro F transferase activity, transferring acyl groups other than amino-acyl groups
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development

Domain Information

InterPro Annotations

Accession Description
IPR002656 Acyltransferase 3
IPR006621 Nose resistant-to-fluoxetine protein, N-terminal

UniProt Annotations

Entry Information

Gene Name
Protein NRF-6
Protein Entry
NRF6_CAEEL
UniProt ID
Q09225
Species
C. elegans

Comments

Comment Type Description
Disruption Phenotype Increased resistance to fluoxetine-induced nose muscle contraction. Slow development, embryonic lethality and defective yolk transport to the oocytes leading to accumulation of yolk granules in the pseudocoelomic fluid and appearance of pale eggs. Reduced level of sensitivity to dihomo-gamma-linolenic acid- induced sterility. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:16487504}.
Function Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:16487504}.
Similarity Belongs to the acyltransferase 3 family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity In L1 larvae through to adult, hyp3 and hyp5, the most anterior cells in the hypodermis, and in intestine. Other hypodermal cells show weaker expression. {ECO:0000269|PubMed:10488330}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008139 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17535341 RefSeq NP_495680 822 Protein NRF-6

Identical Sequences to LMP008139 proteins

Reference Database Accession Length Protein Name
GI:17535341 EMBL CAA86669.2 822 Protein NRF-6 [Caenorhabditis elegans]
GI:17535341 GenBank AAD51972.1 822 transmembrane protein NRF-6 [Caenorhabditis elegans]
GI:17535341 SwissProt Q09225.3 822 RecName: Full=Nose resistant to fluoxetine protein 6; Short=Protein nrf-6; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008139 proteins

Reference Database Accession Length Protein Name
GI:17535341 EMBL CAP32259.2 827 Protein CBR-NRF-6 [Caenorhabditis briggsae]
GI:17535341 EMBL CDJ90705.1 828 Hypothetical protein CBG06590 [Haemonchus contortus]
GI:17535341 GenBank EFO86322.1 840 CRE-NRF-6 protein [Caenorhabditis remanei]
GI:17535341 GenBank EGT38650.1 724 hypothetical protein CAEBREN_31353 [Caenorhabditis brenneri]
GI:17535341 RefSeq XP_002629988.1 821 C. briggsae CBR-NRF-6 protein, partial [Caenorhabditis briggsae]
GI:17535341 RefSeq XP_003117456.1 840 CRE-NRF-6 protein [Caenorhabditis remanei]