Gene/Proteome Database (LMPD)

LMPD ID
LMP008144
Gene ID
174482
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SDHB-1
Gene Symbol
sdhb-1
Synonyms
CELE_F42A8.2
Alternate Names
Protein SDHB-1
Chromosome
II
EC Number
1.3.5.1

Proteins

Protein SDHB-1
Refseq ID NP_495992
Protein GI 17533915
UniProt ID Q09545
mRNA ID NM_063591
Length 298
RefSeq Status REVIEWED
MLARSARLLHSAELAANAIRAASGAPATAAAAEASFPSTDDVAAKTKKTGNRIKTFEIYRFNPEAPGAKPTVQKFDVDLDQCGTMILDALIKIKNEVDPTLTFRRSCREGICGSCAMNIGGQNTLACICKIDSDTSKSTKIYPLPHMFVVKDLVPDMNLFYAQYASIQPWIQKKTPLTLGEKQMHQSVAERDRLDGLYECILCACCSTSCPSYWWNADKYLGPAVLMQAYRWVIDSRDDYATERLHRMHDSFSAFKCHTIMNCTKTCPKHLNPAKAIGEIKSLLTGFTSKPAAEPSAF

Gene Information

Entrez Gene ID
174482
Gene Name
Protein SDHB-1
Gene Symbol
sdhb-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0005749 ISS:UniProtKB C mitochondrial respiratory chain complex II
GO:0005739 IDA:WormBase C mitochondrion
GO:0051537 ISS:UniProtKB F 2 iron, 2 sulfur cluster binding
GO:0051538 ISS:UniProtKB F 3 iron, 4 sulfur cluster binding
GO:0051539 ISS:UniProtKB F 4 iron, 4 sulfur cluster binding
GO:0009055 IEA:InterPro F electron carrier activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0008177 IEA:UniProtKB-EC F succinate dehydrogenase (ubiquinone) activity
GO:0048039 ISS:UniProtKB F ubiquinone binding
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
cel01200 Carbon metabolism
cel00020 Citrate cycle (TCA cycle)
cel_M00009 Citrate cycle (TCA cycle, Krebs cycle)
cel_M00148 Succinate dehydrogenase (ubiquinone)

Domain Information

InterPro Annotations

Accession Description
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
IPR001041 2Fe-2S ferredoxin-type domain
IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
IPR009051 Alpha-helical ferredoxin
IPR012675 Beta-grasp domain
IPR025192 Succinate dehydogenase/fumarate reductase N-terminal
IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein

UniProt Annotations

Entry Information

Gene Name
Protein SDHB-1
Protein Entry
SDHB_CAEEL
UniProt ID
Q09545
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Succinate + a quinone = fumarate + a quinol.
Cofactor Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000250}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
Cofactor Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000250}; Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
Cofactor Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
Function Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Sequence Caution Sequence=BAA23717.1; Type=Frameshift; Positions=4, 15, 28; Evidence={ECO:0000305};
Similarity Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO:0000305}.
Similarity Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
Similarity Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00711}.
Subcellular Location Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Subunit Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008144 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17533915 RefSeq NP_495992 298 Protein SDHB-1

Identical Sequences to LMP008144 proteins

Reference Database Accession Length Protein Name
GI:17533915 EMBL CAA87780.1 298 Protein SDHB-1 [Caenorhabditis elegans]
GI:17533915 GenBank ABZ31578.1 298 Sequence 5516 from patent US 7314974
GI:17533915 SwissProt Q09545.1 298 RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; AltName: Full=Iron-sulfur subunit of complex II; Short=Ip; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008144 proteins

Reference Database Accession Length Protein Name
GI:17533915 DBBJ BAA23717.1 297 iron-sulfur subunit of mitochondrial succinate dehydrogenase [Caenorhabditis elegans]
GI:17533915 EMBL CAP22357.2 282 Protein CBR-SDHB-1 [Caenorhabditis briggsae]
GI:17533915 GenBank EGT46387.1 282 hypothetical protein CAEBREN_09832 [Caenorhabditis brenneri]
GI:17533915 GenBank EGT51763.1 282 hypothetical protein CAEBREN_03271 [Caenorhabditis brenneri]
GI:17533915 RefSeq XP_002629663.1 302 C. briggsae CBR-SDHB-1 protein [Caenorhabditis briggsae]
GI:17533915 SwissProt A8WPF0.2 282 RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; AltName: Full=Iron-sulfur subunit of complex II; Short=Ip; Flags: Precursor [Caenorhabditis briggsae]