Gene/Proteome Database (LMPD)

LMPD ID
LMP008145
Gene ID
174517
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SQV-8
Gene Symbol
sqv-8
Synonyms
CELE_ZK1307.5
Alternate Names
Protein SQV-8
Chromosome
II
EC Number
2.4.1.135

Proteins

Protein SQV-8
Refseq ID NP_496076
Protein GI 17535739
UniProt ID Q09363
mRNA ID NM_063675
Length 356
RefSeq Status REVIEWED
MFPSRLLEKWWLRAFIALVIFFVWQLFYAINRVQSLEEERATLQATIEVLTRKSDGLRTQIFEKERNLVRLNGKVEEIDTQIRDHLSLLPRVNRSTPFIYFITPTHFRAAQRADLTRLSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDQKMRYDDPNWTLPRGVEQRNRALLWIQNQLSGVKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILEKNGSISHFNAVWKPERPFPIDMAAFAVNISLVLSNANALFSFDVPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTEKPKLSKESIDRLTKKTGFNSLEAHALGVDN

Gene Information

Entrez Gene ID
174517
Gene Name
Protein SQV-8
Gene Symbol
sqv-8
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:WormBase C membrane
GO:0015018 IEA:UniProtKB-EC F galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
GO:0015020 IDA:WormBase F glucuronosyltransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0030206 IMP:WormBase P chondroitin sulfate biosynthetic process
GO:0009792 IMP:WormBase P embryo development ending in birth or egg hatching
GO:0002009 IMP:WormBase P morphogenesis of an epithelium
GO:0018991 IMP:WormBase P oviposition
GO:0060465 IMP:WormBase P pharynx development
GO:0000003 IMP:WormBase P reproduction
GO:0007286 IMP:WormBase P spermatid development
GO:0040025 IMP:WormBase P vulval development

KEGG Pathway Links

KEGG Pathway ID Description
cel00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
cel00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
cel_M00057 Glycosaminoglycan biosynthesis, linkage tetrasaccharide

REACTOME Pathway Links

REACTOME Pathway ID Description
5653446 A tetrasaccharide linker sequence is required for GAG synthesis

Domain Information

InterPro Annotations

Accession Description
IPR005027 Glycosyl transferase, family 43
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
Protein SQV-8
Protein Entry
SQV8_CAEEL
UniProt ID
Q09363
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity UDP-glucuronate + 3-beta-D-galactosyl-4-beta- D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D- glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D- xylosylprotein.
Function May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins. Also involved in wild-type vulval invagination.
Similarity Belongs to the glycosyltransferase 43 family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008145 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17535739 RefSeq NP_496076 356 Protein SQV-8

Identical Sequences to LMP008145 proteins

Reference Database Accession Length Protein Name
GI:17535739 EMBL CAA87436.1 356 Protein SQV-8 [Caenorhabditis elegans]
GI:17535739 EMBL CAA06741.1 356 Sqv-8 protein [Caenorhabditis elegans]
GI:17535739 SwissProt Q09363.1 356 RecName: Full=Probable glucuronosyltransferase sqv-8; AltName: Full=Squashed vulva protein 8; AltName: Full=Vulval invagination protein sqv-8 [Caenorhabditis elegans]

Related Sequences to LMP008145 proteins

Reference Database Accession Length Protein Name
GI:17535739 EMBL CAI63871.1 356 beta3-glucuronyltransferase [Caenorhabditis briggsae]
GI:17535739 EMBL CAP22198.1 356 Protein CBR-SQV-8 [Caenorhabditis briggsae]
GI:17535739 GenBank EFO91751.1 428 CRE-SQV-8 protein [Caenorhabditis remanei]
GI:17535739 GenBank EGT51833.1 356 hypothetical protein CAEBREN_11722 [Caenorhabditis brenneri]
GI:17535739 RefSeq XP_002629821.1 356 C. briggsae CBR-SQV-8 protein [Caenorhabditis briggsae]
GI:17535739 RefSeq XP_003094377.1 428 CRE-SQV-8 protein [Caenorhabditis remanei]