Gene/Proteome Database (LMPD)

LMPD ID
LMP008182
Gene ID
176104
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein CUP-4
Gene Symbol
cup-4
Synonyms
CELE_C02C2.3
Alternate Names
Protein CUP-4
Chromosome
III

Proteins

Protein CUP-4
Refseq ID NP_498710
Protein GI 25149303
UniProt ID P34271
mRNA ID NM_066309
Length 433
RefSeq Status REVIEWED
MKIIIFVCFILIFYLPIQKKHVNSQQQGIDSDDGDAESFFNKSYSEHQSALEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIHVSINQREQTMTVHGHIYMRWFDEFLVWDPKDFNNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKVGCAFDFTDYPYDLNKCAINLFSTSTMADVQLQNLYAIPPTLSFGWEEQKMKRIISDFKIQNVSSSALYYTNGNITSSAPITGFDLGSTWSMLAVTVSFVRHSPLFEAAVVTPCIVVASLISMTFFIDSLSSTFLLMMLHFYVQLIFLHDLVEKLPLSVSEIPFCIKLIGILMYTNGLTLVLHSSLLCGSYYKCPVPQQLNKIFVIEEYIPNTFKEKVQIKKEESNKSWRDLMKLIRPIIGFVLIILLICMFFVCLLL

Gene Information

Entrez Gene ID
176104
Gene Name
Protein CUP-4
Gene Symbol
cup-4
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031410 IDA:WormBase C cytoplasmic vesicle
GO:0030659 IDA:UniProtKB C cytoplasmic vesicle membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0015464 NAS:UniProtKB F acetylcholine receptor activity
GO:0005230 IEA:InterPro F extracellular ligand-gated ion channel activity
GO:0005216 TAS:UniProtKB F ion channel activity
GO:0006897 IMP:WormBase P endocytosis
GO:0034220 TAS:GOC P ion transmembrane transport
GO:0030100 IMP:UniProtKB P regulation of endocytosis
GO:0007268 NAS:GOC P synaptic transmission

REACTOME Pathway Links

REACTOME Pathway ID Description
5653198 Ion channel transport
5653329 Ligand-gated ion channel transport
5652506 Transmembrane transport of small molecules

Domain Information

InterPro Annotations

Accession Description
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
IPR018000 Neurotransmitter-gated ion-channel, conserved site

UniProt Annotations

Entry Information

Gene Name
Protein CUP-4
Protein Entry
CUP4_CAEEL
UniProt ID
P34271
Species
C. elegans

Comments

Comment Type Description
Disruption Phenotype Worms display a lack of uptake of GFP from the pseudocoelom into coelomocytes, suggesting a decrease or absence of endocytosis in coelomocytes. Mutants also display a slightly dumpy appearance with a low penetrance defect in distal tip cell leader function, indicating defects in coelomocyte function. {ECO:0000269|PubMed:11560892}.
Function Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor. {ECO:0000269|PubMed:11560892, ECO:0000269|PubMed:15936276}.
Similarity Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
Subcellular Location Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15936276}; Multi-pass membrane protein {ECO:0000269|PubMed:15936276}.
Tissue Specificity Expressed in coelomocytes. {ECO:0000269|PubMed:15936276}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008182 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25149303 RefSeq NP_498710 433 Protein CUP-4

Identical Sequences to LMP008182 proteins

Reference Database Accession Length Protein Name
GI:25149303 EMBL CCD62529.1 433 Protein CUP-4 [Caenorhabditis elegans]
GI:25149303 GenBank AAT42012.1 433 CUP-4 [Caenorhabditis elegans]
GI:25149303 SwissProt P34271.2 433 RecName: Full=Acetylcholine receptor-like protein cup-4; AltName: Full=Coelomocyte uptake defective protein 4; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008182 proteins

Reference Database Accession Length Protein Name
GI:25149303 EMBL CAP31276.2 435 Protein CBR-CUP-4 [Caenorhabditis briggsae]
GI:25149303 GenBank EFP04230.1 435 CRE-CUP-4 protein [Caenorhabditis remanei]
GI:25149303 GenBank EGT56552.1 439 CBN-CUP-4 protein [Caenorhabditis brenneri]
GI:25149303 RefSeq XP_002642687.1 530 C. briggsae CBR-CUP-4 protein [Caenorhabditis briggsae]
GI:25149303 RefSeq XP_003103172.1 435 CRE-CUP-4 protein [Caenorhabditis remanei]
GI:25149303 SwissProt A8XF54.2 435 RecName: Full=Acetylcholine receptor-like protein cup-4; AltName: Full=Coelomocyte uptake defective protein 4; Flags: Precursor [Caenorhabditis briggsae]