Gene/Proteome Database (LMPD)

LMPD ID
LMP008189
Gene ID
176332
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein BRE-3
Gene Symbol
bre-3
Synonyms
CELE_B0464.4
Alternate Names
Protein BRE-3
Chromosome
III
EC Number
2.4.1.-

Proteins

Protein BRE-3
Refseq ID NP_499087
Protein GI 71980894
UniProt ID Q03562
mRNA ID NM_066686
Length 455
RefSeq Status REVIEWED
MNCEVKHALHCAVLVAWIVCFAYFCGVFTEPVEGSVPESPVASYGLIWTVCLYLLRFTALLVLPQCLCNLGGLMMFNAFREKVQLKAAPLLSPFVCFRVVTKGNFPLLVKENIDTNMKTCFEAGMENFIFEVVTDKAINLPPNPRVREVVVPTVYKTKSGAKFKARALQYCLEDDVNILQPTDWIVHLDEETLLTTNAICGILNFCEDGKHQFGQGVITYANGDIVNWLTTLSDSFRVADDMGKLRFQFKLFHKPLFGWKGSYVVTQVEAERDVSYDHGMEGSIAEDCFFSMVAMKHGYSFDFIEGEMHEKSPFTMWDFLQQRKRWLQGILLTVHSSKIAVVHKALLALSLYAWATMPLTSLQVFLCPLFPLPRCLPFDFLLSFVGALNLYMYIFGVVKSFSHKYRNSLLRLAMYLAGALMTIPFNILIENAAVLVGMFGRKDQFYIVNKDIQTV

Gene Information

Entrez Gene ID
176332
Gene Name
Protein BRE-3
Gene Symbol
bre-3
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0019187 IDA:UniProtKB F beta-1,4-mannosyltransferase activity
GO:0075015 IMP:UniProtKB P formation of infection structure on or near host
GO:0006688 ISS:UniProtKB P glycosphingolipid biosynthetic process
GO:0097502 IDA:GOC P mannosylation
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
cel04320 Dorso-ventral axis formation
ko04320 Dorso-ventral axis formation

Domain Information

InterPro Annotations

Accession Description
IPR027389 Beta-1,4-mannosyltransferase Bre-3/Egh
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
Protein BRE-3
Protein Entry
BRE3_CAEEL
UniProt ID
Q03562
Species
C. elegans

Comments

Comment Type Description
Disruption Phenotype Worms exhibit resistance to the Cry5B toxin produced by Bacillus thuringiensis. This is thought to be due to mutants having reduced population of glycolipids which are targeted by the Cry5B protein. Mutants also have reduced brood sizes at only 17% of wild-type N2. {ECO:0000269|PubMed:10924467, ECO:0000269|PubMed:12944392}.
Function Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre- 4 and bre-5. Has a role in determining brood size. {ECO:0000269|PubMed:10924467, ECO:0000269|PubMed:12944392}.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12944392}. Note=In punctate structures throughout the cell.
Tissue Specificity Endothelial cells. {ECO:0000269|PubMed:12944392}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008189 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71980894 RefSeq NP_499087 455 Protein BRE-3

Identical Sequences to LMP008189 proteins

Reference Database Accession Length Protein Name
GI:71980894 EMBL CAA79538.2 455 Protein BRE-3 [Caenorhabditis elegans]
GI:71980894 GenBank AAS21307.1 455 BRE-3 [Caenorhabditis elegans]
GI:71980894 GenBank ADS21444.1 455 Sequence 8 from patent US 7771978
GI:71980894 SwissProt Q03562.2 455 RecName: Full=Beta-1,4-mannosyltransferase bre-3; AltName: Full=Bacillus thuringiensis toxin-resistant protein 3; Short=Bt toxin-resistant protein 3 [Caenorhabditis elegans]

Related Sequences to LMP008189 proteins

Reference Database Accession Length Protein Name
GI:71980894 EMBL CAP29592.3 455 Protein CBR-BRE-3 [Caenorhabditis briggsae]
GI:71980894 GenBank EFP09355.1 455 CRE-BRE-3 protein [Caenorhabditis remanei]
GI:71980894 GenBank EGT33800.1 455 CBN-BRE-3 protein [Caenorhabditis brenneri]
GI:71980894 RefSeq XP_002641743.1 455 C. briggsae CBR-BRE-3 protein [Caenorhabditis briggsae]
GI:71980894 RefSeq XP_003113101.1 455 CRE-BRE-3 protein [Caenorhabditis remanei]
GI:71980894 SwissProt A8XAC4.1 455 RecName: Full=Beta-1,4-mannosyltransferase bre-3; AltName: Full=Bacillus thuringiensis toxin-resistant protein 3; Short=Bt toxin-resistant protein 3 [Caenorhabditis briggsae]