Gene/Proteome Database (LMPD)

LMPD ID
LMP008290
Gene ID
179879
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein NRF-5
Gene Symbol
nrf-5
Synonyms
CELE_F55B12.5
Chromosome
V

Proteins

Protein NRF-5
Refseq ID NP_506424
Protein GI 32566904
UniProt ID Q93796
mRNA ID NM_074023
Length 551
RefSeq Status REVIEWED
MSRNFHIFFLLVSIIQVGNSADSSEITHKPAGIYVRLNQKAVDYVADLASDALPAILNNLSPPDIVTDMAKITKLHISNVAKPNLSAKFIDGKGVAYNISLASFRASAYAEISVFVWSYEGDFTAELRELSIESELHFDYNGTTTVNASVCNVTHSELSLVFPPGSSLSALQSEIKGQIVSALRDAVCTTAVEALTFVMAQKPIPPESPNYQKPEAGDPNGFSVAELGASLCQVDTVNGFEDSEQEEGNVETTVAPTPDDDNSTLTTEETQKSYWGVDLSVNHPPTFTDEDMIIGLDGGILFNGWKADSAQQLQILNKTRLDKKMVGILLSEYIPNTLFHHIYMYDLGNFKHRYTPSSLPKILQKLSKAVCSKCYVEVSANLTEQPILQIDAHLGARVQLSGNVSIMFHGREQLHDVLHANTKLHVTLKPTVRHSRIFGDVSLTNVDVNVFDLGLGGPLAAPIEKLFSFVVPRVLWPQVKKRLRFAMNRRGVKLPIFCGVELEHTELDFVDHAVLLNTDFSFDLPLFLAKFKKYLDAKSKINPNLPKYVII

Gene Information

Entrez Gene ID
179879
Gene Name
Protein NRF-5
Gene Symbol
nrf-5
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IDA:WormBase C extracellular region
GO:0001786 IDA:WormBase F phosphatidylserine binding
GO:0006869 IDA:WormBase P lipid transport
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:1901076 IMP:WormBase P positive regulation of engulfment of apoptotic cell

Domain Information

InterPro Annotations

Accession Description
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal

UniProt Annotations

Entry Information

Gene Name
Protein NRF-5
Protein Entry
Q93796_CAEEL
UniProt ID
Q93796
Species
C. elegans

Comments

Comment Type Description
Disruption Phenotype Increased resistance to fluoxetine-induced nose muscle contraction. Slow development, embryonic lethality and defect in yolk transport to oocytes leading to accumulation of yolk granules in the pseudocoelomic fluid and appearance of pale eggs. Reduced level of sensitivity to dihomo-gamma-linolenic acid- induced sterility. Cell corpses persist significantly longer than in the wild-type, indicating a cell corpse clearance defect. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:16487504, ECO:0000269|PubMed:22727700}.
Function Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16487504, ECO:0000269|PubMed:22727700, ECO:0000305}.
Similarity Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular Location Secreted .
Subunit Interacts with ttr-52.
Tissue Specificity Expressed in the body wall muscle cells and detected at the basal surface of pharyngeal cells and basal- lateral membranes of the intestine. {ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:22727700}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008290 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
32566904 RefSeq NP_506424 551 Protein NRF-5

Identical Sequences to LMP008290 proteins

Reference Database Accession Length Protein Name
GI:32566904 EMBL CAB02126.2 551 Protein NRF-5 [Caenorhabditis elegans]
GI:32566904 SwissProt Q93796.2 551 RecName: Full=Nose resistant to fluoxetine protein 5; Short=Protein nrf-5; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008290 proteins

Reference Database Accession Length Protein Name
GI:32566904 EMBL CAP30494.2 544 Protein CBR-NRF-5 [Caenorhabditis briggsae]
GI:32566904 GenBank AAS18681.1 573 nose resistant to fluoxetine, partial [Caenorhabditis elegans]
GI:32566904 GenBank EFO87620.1 548 CRE-NRF-5 protein [Caenorhabditis remanei]
GI:32566904 GenBank EGT42513.1 548 CBN-NRF-5 protein [Caenorhabditis brenneri]
GI:32566904 RefSeq XP_002635230.1 561 C. briggsae CBR-NRF-5 protein [Caenorhabditis briggsae]
GI:32566904 RefSeq XP_003110327.1 548 CRE-NRF-5 protein [Caenorhabditis remanei]