Gene/Proteome Database (LMPD)

LMPD ID
LMP008310
Gene ID
180485
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein D1005.1
Gene Symbol
D1005.1
Synonyms
CELE_D1005.1
Alternate Names
Protein D1005.1
Chromosome
X
EC Number
2.3.3.8

Proteins

Protein D1005.1
Refseq ID NP_508280
Protein GI 17551266
UniProt ID P53585
mRNA ID NM_075879
Length 1106
RefSeq Status REVIEWED
MSAKAVSELSGKEVLYKYFEPSGLLSAPHAFHVKAGENFDEIANKYEWLARDNKGVIKPDQLIKRRGKLGLVKIGTPQELKAWFEKTGDSYVRVGQTEGRLHTFIVEPFCAHTEKDEMYIAIYSERFRDVIMFYEQGGVDIGDVEEKARTVSVPVQLNENAMTPSDEELTTLLGPLKDSDIVRRFVVELYKAYKDLHFTYLEINPFVLLNNQIHVLDLAARLDETANFLCADKWKSRLTPYGGPNHVEFPAPFGRDLTSEEQYISEMDAKTGASLKLTILNRKGRVWTMVAGGGASVVFTDTVCDLGGASELANYGEYSGDPSESQTYEYAKTLLSVMTEGTPRPDGKVLIIGGSIANFTNVAKTFGGIVRAFETFVSKLKEHKVTIFVRRGGPNYQEGLRRIKDAATKLELPIHVFGPETHMTAIVGAALGVKPMPTVPTAPQTTGQFLLSPERNTGGTERAPPSPAANATPTEHPLTTAQQNKLKSFRGLFEDDTKAIIWGQQAKAIQGMLDFDYVCRRSSPSVVASTYPFTGDNKQKYYFGQKEILIPAYKSMAKAFATHPDASIMVTFASMRSVFETVLEALEFPQIKVIAIIAEGVPENQTRKLLKIAHDRGVTLVGPATVGGIKPGCFKIGNTGGMMDNILASKLYRPGSVAYVSRSGGMSNELNNIISQNTNGVYEGIAIGGDRYPGSTYTDHVIRYQNDDRVKMIVLLGEVGGVEEYKIVDLLKQKKVTKPLVAWCIGTCADHITSEVQFGHAGASANALGETAACKNAALRASGALVPESFDDLGNKIRQTYDELVSQQIIVPQPEVPPPAVPMDYAWARELGLIRKPASFMTSICDERGEELNYAGVPITKVLESDMGIGGVLGLLWFQKRLPPHANKFIEICLMLTADHGPAVSGAHNTIVCARAGKDLISSLTSGLLTIGDRFGGALDGAARQFSEAFDQGWSANQFVSEMRKKGKHIMGIGHRVKSINNPDKRVEILKRFAMDKKEFAQETPLFEYALEVEKITTAKKPNLILNVDGAIAILFVDILRHSGMFTKQEAEETIEIGSLNGLFVLGRSIGFIGHYLDQSRLKQGLYRHPWDDISYIMPESNLVKF

Gene Information

Entrez Gene ID
180485
Gene Name
Protein D1005.1
Gene Symbol
D1005.1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003878 IEA:UniProtKB-EC F ATP citrate synthase activity
GO:0048037 IEA:InterPro F cofactor binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004775 IEA:InterPro F succinate-CoA ligase (ADP-forming) activity
GO:0044262 IEA:InterPro P cellular carbohydrate metabolic process
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
cel00020 Citrate cycle (TCA cycle)
cel01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5652875 ChREBP activates metabolic gene expression

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
IPR014608 ATP-citrate synthase
IPR013816 ATP-grasp fold, subdomain 2
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR002020 Citrate synthase-like
IPR016141 Citrate synthase-like, core
IPR016142 Citrate synthase-like, large alpha subdomain
IPR016143 Citrate synthase-like, small alpha subdomain
IPR003781 CoA-binding
IPR016040 NAD(P)-binding domain
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
Protein D1005.1
Protein Entry
ACLY_CAEEL
UniProt ID
P53585
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
Function ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. {ECO:0000250}.
Similarity In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000305}.
Similarity In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008310 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17551266 RefSeq NP_508280 1106 Protein D1005.1

Identical Sequences to LMP008310 proteins

Reference Database Accession Length Protein Name
GI:17551266 EMBL CCD68276.1 1106 Protein D1005.1 [Caenorhabditis elegans]
GI:17551266 SwissProt P53585.1 1106 RecName: Full=Probable ATP-citrate synthase; AltName: Full=ATP-citrate (pro-S-)-lyase; AltName: Full=Citrate cleavage enzyme [Caenorhabditis elegans]

Related Sequences to LMP008310 proteins

Reference Database Accession Length Protein Name
GI:17551266 EMBL CAP21104.2 1106 Protein CBG24512 [Caenorhabditis briggsae]
GI:17551266 GenBank EFO96702.1 1112 hypothetical protein CRE_17185 [Caenorhabditis remanei]
GI:17551266 GenBank EGT54923.1 1109 hypothetical protein CAEBREN_17405 [Caenorhabditis brenneri]
GI:17551266 RefSeq XP_002648327.1 1112 Hypothetical protein CBG24512 [Caenorhabditis briggsae]
GI:17551266 RefSeq XP_003106862.1 1112 hypothetical protein CRE_17185 [Caenorhabditis remanei]
GI:17551266 RefSeq XP_003112530.1 1099 hypothetical protein CRE_30753 [Caenorhabditis remanei]