Gene/Proteome Database (LMPD)

LMPD ID
LMP008323
Gene ID
181108
Species
Caenorhabditis elegans (C. elegans)
Gene Name
Protein SDHA-1
Gene Symbol
sdha-1
Synonyms
CELE_C03G5.1
Alternate Names
Protein SDHA-1
Chromosome
X
EC Number
1.3.5.1

Proteins

Protein SDHA-1
Refseq ID NP_509446
Protein GI 17550100
UniProt ID Q09508
mRNA ID NM_077045
Length 646
RefSeq Status REVIEWED
MLRAASNGLRNTVAARSVSLSAANHSDAKRSDIAQYKVVDHAYDAVVVGAGGAGLRAAMGLAEGGLKTAVITKLFPTRSHTVAAQGGINAALGNMNPDNWRWHFYDTVKGSDWLGDQDAIHYMTREAERAVIELENYGMPFSRTTDGKIYQRAFGGQSNDFGRGGQAHRTCCVADRTGHSLLHTLYGASLQYNCNYFVEYFALDLIMENGVCVGVIAMDLEDGTIHRFRSKNTVLATGGYGRAFFSCTSAHTCTGDGTALTARAGINNSDMEFVQFHPTGIYGAGCLITEGSRGEGGYLVNSAGERFMERYAPNAKDLASRDVVSRSMTVEIMEGRGVGPDKDHIYLQLHHLPAEQLQQRLPGISETAMIFAGVDVTKEPIPVIPTVHYNMGGVPTNYKGQVLNYTPKKGDEVVPGLYAAGECGAHSVHGANRLGANSLLDLVIFGRACAIDILKNTSAGVGVPELPKNAGEASVANIDKLRHNKGDISTAELRLTMQKSMQNHAAVFRRGDILKEGVKVLSKLYKDQAHLNVADKGLVWNSDLIETLELQNLLINATQTIVAAENREESRGAHARDDFPDRLDELDYSKPLEGQTKKELKDHWRKHSIIRSNIETGEVSLDYRPVIDTTLDKSETDWVPPKVRSY

Gene Information

Entrez Gene ID
181108
Gene Name
Protein SDHA-1
Gene Symbol
sdha-1
Species
Caenorhabditis elegans

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0005739 IDA:WormBase C mitochondrion
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0008177 IEA:UniProtKB-EC F succinate dehydrogenase (ubiquinone) activity
GO:0022900 IEA:InterPro P electron transport chain
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
cel01200 Carbon metabolism
cel00020 Citrate cycle (TCA cycle)
cel_M00009 Citrate cycle (TCA cycle, Krebs cycle)
cel_M00148 Succinate dehydrogenase (ubiquinone)

Domain Information

InterPro Annotations

Accession Description
IPR003953 FAD binding domain
IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
IPR011281 Succinate dehydrogenase, flavoprotein subunit
IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

UniProt Annotations

Entry Information

Gene Name
Protein SDHA-1
Protein Entry
SDHA_CAEEL
UniProt ID
Q09508
Species
C. elegans

Comments

Comment Type Description
Catalytic Activity Succinate + a quinone = fumarate + a quinol.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Similarity Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.
Subcellular Location Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Subunit Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008323 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17550100 RefSeq NP_509446 646 Protein SDHA-1

Identical Sequences to LMP008323 proteins

Reference Database Accession Length Protein Name
GI:17550100 EMBL CCD62793.1 646 Protein SDHA-1 [Caenorhabditis elegans]
GI:17550100 GenBank ABZ32907.1 646 Sequence 6845 from patent US 7314974
GI:17550100 SwissProt Q09508.3 646 RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; AltName: Full=Flavoprotein subunit of complex II; Short=FP; Flags: Precursor [Caenorhabditis elegans]

Related Sequences to LMP008323 proteins

Reference Database Accession Length Protein Name
GI:17550100 DBBJ BAA21637.1 646 flavoprotein subunit of complex II [Caenorhabditis elegans]
GI:17550100 EMBL CAP39299.1 645 Protein CBR-SDHA-1 [Caenorhabditis briggsae]
GI:17550100 GenBank EFP09673.1 652 CRE-SDHA-1 protein [Caenorhabditis remanei]
GI:17550100 GenBank EGT34444.1 646 CBN-SDHA-1 protein [Caenorhabditis brenneri]
GI:17550100 RefSeq XP_002645529.1 645 C. briggsae CBR-SDHA-1 protein [Caenorhabditis briggsae]
GI:17550100 RefSeq XP_003100196.1 652 CRE-SDHA-1 protein [Caenorhabditis remanei]