Gene/Proteome Database (LMPD)
LMPD ID
LMP008790
Gene ID
Species
Drosophila melanogaster (Drosophila)
Gene Name
HMG Coenzyme A reductase
Gene Symbol
Synonyms
BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; Dmel\CG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; hmgrc; l(3)01152; l(3)04684
Chromosome
3R
Map Location
95B1-95B1
Proteins
| HMG coenzyme A reductase | |
|---|---|
| Refseq ID | NP_732900 |
| Protein GI | 24649399 |
| UniProt ID | P14773 |
| mRNA ID | NM_170089 |
| Length | 920 |
| RefSeq Status | REVIEWED |
| MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDKNNTLDASSGLGTATASAAAAGGSGSGAGSGASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQAEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFYPACLSLIFDLSRSGVDMSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVHIYSRVAFSGSDYDAVDKTLTPTLSLNVSNNRTESGEIADIIIKWLTMSADHIVISIVLIALVVKFICFDNRDPLPDQLRQSGPVAIAAKASQTTPIDEEHVEQEKDTENSAAVRTLLFTIEDQSSANASTQTDLLPLRHRLVGPIKPPRPVQECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSANNPLNVTVSSCSTIS | |
Gene Information
Entrez Gene ID
Gene Name
HMG Coenzyme A reductase
Gene Symbol
Species
Drosophila melanogaster
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IEA:InterPro | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:InterPro | C | integral component of membrane |
| GO:0050661 | IEA:InterPro | F | NADP binding |
| GO:0004420 | IEA:UniProtKB-EC | F | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| GO:0015936 | IEA:InterPro | P | coenzyme A metabolic process |
| GO:0008299 | IEA:InterPro | P | isoprenoid biosynthetic process |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR023282 | Hydroxymethylglutaryl-CoA reductase, N-terminal |
| IPR002202 | Hydroxymethylglutaryl-CoA reductase, class I/II |
| IPR009023 | Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain |
| IPR023074 | Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain |
| IPR023076 | Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site |
| IPR009029 | Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain |
| IPR004554 | Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type |
| IPR004816 | Hydroxymethylglutaryl-CoA reductase, metazoan |
| IPR000731 | Sterol-sensing domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | (R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH. |
| Pathway | Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. |
| Similarity | Belongs to the HMG-CoA reductase family. |
| Subcellular Location | Endoplasmic reticulum membrane ; Multi-pass membrane protein . |
Identical and Related Proteins
Unique RefSeq proteins for LMP008790 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24649399 | RefSeq | NP_732900 | 920 | HMG coenzyme A reductase |
Identical Sequences to LMP008790 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24649399 | GenBank | AGW24091.1 | 920 | FI22020p1 [Drosophila melanogaster] |
| GI:24649399 | gnl | FlyBase | 920 | HMG coenzyme A reductase [Drosophila melanogaster] |
| GI:24649399 | SwissProt | P14773.2 | 920 | RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase [Drosophila melanogaster] |
Related Sequences to LMP008790 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24649399 | GenBank | ABY20416.1 | 920 | AT09917p [Drosophila melanogaster] |
| GI:24649399 | GenBank | EDV53973.1 | 973 | GG11225 [Drosophila erecta] |
| GI:24649399 | GenBank | EDW43371.1 | 944 | GM26526 [Drosophila sechellia] |
| GI:24649399 | GenBank | EDW98180.1 | 954 | GE10390 [Drosophila yakuba] |
| GI:24649399 | RefSeq | XP_002032385.1 | 944 | GM26526 [Drosophila sechellia] |
| GI:24649399 | RefSeq | XP_002098468.1 | 954 | GE10390 [Drosophila yakuba] |