Gene/Proteome Database (LMPD)

LMPD ID
LMP008793
Gene ID
37196
Species
Drosophila melanogaster (Drosophila)
Gene Name
5-hydroxytryptamine (serotonin) receptor 1A
Gene Symbol
5-HT1A
Synonyms
5-HT-dro2A; 5-HT1ADro; 5-HT[1A]Dro; 5-HT[[1ADro]]; 5-HT[[1A]]; 5-HT[[1A]]DRO; 5HT-dro2A; 5HT-drp[[2A]]; 5HT-R2A; 5HT1A; 5htdro2a; 5HT[[1ADro]]; CG16720; d5-HT1A; Dm5HTdro2A; Dmel\CG16720; DRO2A
Alternate Names
5-HT1A-PB; 5-hydroxytryptamine (serotonin) receptor 1A; CG16720-PB; serotonin receptor 1A; serotonin receptor 2A; serotonin-receptor-2A
Chromosome
2R
Map Location
56B2-56B5

Proteins

5-hydroxytryptamine (serotonin) receptor 1A
Refseq ID NP_725849
Protein GI 24655424
UniProt ID P28285
mRNA ID NM_166322
Length 834
RefSeq Status REVIEWED
MAHETSFNDALDYIYIANSMNDRAFLIAEPHPEQPNVDGQDQDDAELEELDDMAVTDDGQLEDTNNNNNSKRYYSSGKRRADFIGSLALKPPPTDVNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTKQDATSSPASSPALQLIDMDNNYTNVAVGLGAMLLNDTLLLEGNDSSLFGEMLANRSGQLDLINGTGGLNVTTSKVAEDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTNIDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQFGWKDPDYLQRIEQQKCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRPRPVDAAVNNNQPDGGAATDTKLHRLRLRLGRFSTAKSKTGSAVGVSGPASGGRALGLVDGNSTNTVNTVEDTEFSSSNVDSKSRAGVEAPSTSGNQIATVSHLVALAKQQGKSTAKSSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKANGVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGPMTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHNNLSSIANPMQKVNKRKETLEAKRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGGHRPVHYRSGKL

Gene Information

Entrez Gene ID
37196
Gene Name
5-hydroxytryptamine (serotonin) receptor 1A
Gene Symbol
5-HT1A
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 ISS:FlyBase C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008227 ISS:FlyBase F G-protein coupled amine receptor activity
GO:0001586 NAS:FlyBase F Gi/o-coupled serotonin receptor activity
GO:0004993 IDA:FlyBase F serotonin receptor activity
GO:0007198 IDA:FlyBase P adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007615 IDA:FlyBase P anesthesia-resistant memory
GO:0007208 IDA:FlyBase P phospholipase C-activating serotonin receptor signaling pathway
GO:0045187 IMP:FlyBase P regulation of circadian sleep/wake cycle, sleep
GO:0007210 IDA:FlyBase P serotonin receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
dme04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
6226617 G alpha (i) signalling events
6226200 GPCR downstream signaling
6226651 Serotonin receptors

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
5-hydroxytryptamine (serotonin) receptor 1A
Protein Entry
5HT2A_DROME
UniProt ID
P28285
Species
Drosophila

Comments

Comment Type Description
Function This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.
Sequence Caution Sequence=AAY84887.1; Type=Erroneous termination; Positions=49; Note=Translated as Glu.; Evidence={ECO:0000305};
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP008793 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24655424 RefSeq NP_725849 834 5-hydroxytryptamine (serotonin) receptor 1A

Identical Sequences to LMP008793 proteins

Reference Database Accession Length Protein Name
GI:24655424 gnl FlyBase 834 5-hydroxytryptamine (serotonin) receptor 1A [Drosophila melanogaster]

Related Sequences to LMP008793 proteins

Reference Database Accession Length Protein Name
GI:24655424 EMBL CAA77570.1 834 5HT-dro2A receptor (serotonin receptor) [Drosophila melanogaster]
GI:24655424 GenBank EDX07771.1 832 GD11428 [Drosophila simulans]
GI:24655424 GenBank AGV77177.1 834 FI21522p1 [Drosophila melanogaster]
GI:24655424 RefSeq XP_001974771.1 833 GG21944 [Drosophila erecta]
GI:24655424 RefSeq XP_002082186.1 832 GD11428 [Drosophila simulans]
GI:24655424 SwissProt P28285.2 834 RecName: Full=5-hydroxytryptamine receptor 2A; Short=5-HT receptor 2A; AltName: Full=Serotonin receptor 2A [Drosophila melanogaster]