Gene/Proteome Database (LMPD)

LMPD ID
LMP008826
Gene ID
36760
Species
Drosophila melanogaster (Drosophila)
Gene Name
ATP citrate lyase
Gene Symbol
ATPCL
Synonyms
anon-WO0140519.179; BcDNA:LD21334; CG8322; dATPCL; DmATPCL; Dmel\CG8322; l(2)01466; l(2)k09217; n(2)k09217
Chromosome
2R
Map Location
52D10-52D12

Proteins

ATP citrate lyase, isoform D
Refseq ID NP_523755
Protein GI 281363473
UniProt ID Q7KN85
mRNA ID NM_079031
Length 1112
RefSeq Status REVIEWED
MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLLPGGQQAQADLKAASDASEALGSGSALSPTAAKPIKLPPISADEADSAGISGAQRNGSSLNRKFFSNTTKAIVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHKEVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGVKPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPGSTFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFGHAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKFFEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNLHPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKPNLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLYRHPWDDISYVIPEQYN
ATP citrate lyase, isoform E
Refseq ID NP_001137674
Protein GI 281363475
UniProt ID Q7KN85
mRNA ID NM_001144202
Length 1112
RefSeq Status REVIEWED
MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLLPGGQQAQADLKAASDASEALGSGSALSPTAAKPIKLPPISADEADSAGISGAQRNGSSLNRKFFSNTTKAIVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHKEVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGVKPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPGSTFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFGHAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKFFEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNLHPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKPNLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLYRHPWDDISYVIPEQYN
ATP citrate lyase, isoform F
Refseq ID NP_725514
Protein GI 281363477
UniProt ID E2QCF1
mRNA ID NM_166131
Length 1095
RefSeq Status REVIEWED
MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLLPGGQQAQADLKAASDASEALGSGSDEADSAGISGAQRNGSSLNRKFFSNTTKAIVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHKEVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGVKPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPGSTFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFGHAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKFFEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNLHPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKPNLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLYRHPWDDISYVIPEQYN
ATP citrate lyase, isoform G
Refseq ID NP_001286470
Protein GI 665401237
UniProt ID E2QCF1
mRNA ID NM_001299541
Length 1096
RefSeq Status REVIEWED
MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLLPGGQQAQADLKAASDASEALGSGSADEADSAGISGAQRNGSSLNRKFFSNTTKAIVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHKEVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGVKPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPGSTFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFGHAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKFFEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNLHPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKPNLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLYRHPWDDISYVIPEQYN

Gene Information

Entrez Gene ID
36760
Gene Name
ATP citrate lyase
Gene Symbol
ATPCL
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:InterPro C cytoplasm
GO:0005811 IDA:FlyBase C lipid particle
GO:0005524 IEA:InterPro F ATP binding
GO:0003878 ISS:FlyBase F ATP citrate synthase activity
GO:0048037 IEA:InterPro F cofactor binding
GO:0016829 IEA:UniProtKB-KW F lyase activity
GO:0004775 IEA:UniProtKB-EC F succinate-CoA ligase (ADP-forming) activity
GO:0044262 IEA:InterPro P cellular carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme00020 Citrate cycle (TCA cycle)
ko00020 Citrate cycle (TCA cycle)
dme01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6226268 ChREBP activates metabolic gene expression
6225964 Fatty acid, triacylglycerol, and ketone body metabolism
6226048 Fatty Acyl-CoA Biosynthesis
6226181 Integration of energy metabolism
6225882 Metabolism
6225965 Metabolism of lipids and lipoproteins
6226049 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site
IPR014608 ATP-citrate synthase
IPR013816 ATP-grasp fold, subdomain 2
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR002020 Citrate synthase-like
IPR016141 Citrate synthase-like, core
IPR016142 Citrate synthase-like, large alpha subdomain
IPR016143 Citrate synthase-like, small alpha subdomain
IPR003781 CoA-binding
IPR016040 NAD(P)-binding domain
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
IPR016102 Succinyl-CoA synthetase-like

UniProt Annotations

Entry Information

Gene Name
ATP citrate lyase
Protein Entry
Q7KN85_DROME
UniProt ID
Q7KN85
Species
Drosophila

Identical and Related Proteins

Unique RefSeq proteins for LMP008826 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
281363473 RefSeq NP_523755 1112 ATP citrate lyase, isoform D
281363475 RefSeq NP_001137674 1112 ATP citrate lyase, isoform E
281363477 RefSeq NP_725514 1095 ATP citrate lyase, isoform F
665401237 RefSeq NP_001286470 1096 ATP citrate lyase, isoform G

Identical Sequences to LMP008826 proteins

Reference Database Accession Length Protein Name
GI:281363473 GenBank AAD34754.2 1112 LD21334p [Drosophila melanogaster]
GI:281363475 GenBank AAD34754.2 1112 LD21334p [Drosophila melanogaster]
GI:281363475 GenBank AAD34754.2 1112 LD21334p [Drosophila melanogaster]
GI:281363475 GenBank AGN68582.1 1112 Sequence 39 from patent US 8431381
GI:281363475 GenBank AGN68582.1 1112 Sequence 39 from patent US 8431381
GI:281363473 GenBank AGN68582.1 1112 Sequence 39 from patent US 8431381
GI:281363475 gnl FlyBase 1112 ATP citrate lyase, isoform D [Drosophila melanogaster]
GI:281363475 gnl FlyBase 1112 ATP citrate lyase, isoform D [Drosophila melanogaster]
GI:281363473 gnl FlyBase 1112 ATP citrate lyase, isoform D [Drosophila melanogaster]
GI:281363475 gnl FlyBase 1112 ATP citrate lyase, isoform E [Drosophila melanogaster]
GI:281363473 gnl FlyBase 1112 ATP citrate lyase, isoform E [Drosophila melanogaster]
GI:281363475 gnl FlyBase 1112 ATP citrate lyase, isoform E [Drosophila melanogaster]
GI:281363477 gnl FlyBase 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:665401237 gnl FlyBase 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]
GI:281363475 RefSeq NP_523755.2 1112 ATP citrate lyase, isoform D [Drosophila melanogaster]
GI:281363475 RefSeq NP_523755.2 1112 ATP citrate lyase, isoform D [Drosophila melanogaster]
GI:281363473 RefSeq NP_001137674.2 1112 ATP citrate lyase, isoform E [Drosophila melanogaster]

Related Sequences to LMP008826 proteins

Reference Database Accession Length Protein Name
GI:281363473 GenBank AAT94429.1 1112 RE70805p [Drosophila melanogaster]
GI:281363475 GenBank AAT94429.1 1112 RE70805p [Drosophila melanogaster]
GI:281363477 GenBank EDW48057.1 1095 GM20101 [Drosophila sechellia]
GI:281363473 GenBank EDW92008.1 1096 GE14108 [Drosophila yakuba]
GI:281363475 GenBank EDW92008.1 1096 GE14108 [Drosophila yakuba]
GI:665401237 GenBank EDW92008.1 1096 GE14108 [Drosophila yakuba]
GI:665401237 GenBank EDX07279.1 1095 GD25577 [Drosophila simulans]
GI:281363477 GenBank EDX07279.1 1095 GD25577 [Drosophila simulans]
GI:665401237 gnl FlyBase 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:281363473 gnl FlyBase 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:281363475 gnl FlyBase 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:281363473 gnl FlyBase 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]
GI:281363477 gnl FlyBase 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]
GI:281363475 gnl FlyBase 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]
GI:281363477 RefSeq XP_002034044.1 1095 GM20101 [Drosophila sechellia]
GI:665401237 RefSeq XP_002092296.1 1096 GE14108 [Drosophila yakuba]
GI:281363477 RefSeq XP_002081694.1 1095 GD25577 [Drosophila simulans]
GI:665401237 RefSeq XP_002081694.1 1095 GD25577 [Drosophila simulans]
GI:665401237 RefSeq NP_725514.2 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:281363475 RefSeq NP_725514.2 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:281363473 RefSeq NP_725514.2 1095 ATP citrate lyase, isoform F [Drosophila melanogaster]
GI:281363473 RefSeq NP_001286470.1 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]
GI:281363475 RefSeq NP_001286470.1 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]
GI:281363477 RefSeq NP_001286470.1 1096 ATP citrate lyase, isoform G [Drosophila melanogaster]