Gene/Proteome Database (LMPD)

LMPD ID
LMP008844
Gene ID
31358
Species
Drosophila melanogaster (Drosophila)
Gene Name
brainiac
Gene Symbol
brn
Synonyms
brc; Brn; CG4934; Dmel\CG4934; EG:EG0007.6; fs(1)107; fs(1)A107; l(1)6P6
Chromosome
X
Map Location
4A5-4A5

Proteins

brainiac
Refseq ID NP_476901
Protein GI 17136782
UniProt ID Q24157
mRNA ID NM_057553
Length 325
RefSeq Status REVIEWED
MQSKHRKLLLRCLLVLPLILLVDYCGLLTHLHELNFERHFHYPLNDDTGSGSASSGLDKFAYLRVPSFTAEVPVDQPARLTMLIKSAVGNSRRREAIRRTWGYEGRFSDVHLRRVFLLGTAEDSEKDVAWESREHGDILQAEFTDAYFNNTLKTMLGMRWASDQFNRSEFYLFVDDDYYVSAKNVLKFLGRGRQSHQPELLFAGHVFQTSPLRHKFSKWYVSLEEYPFDRWPPYVTAGAFILSQKALRQLYAASVHLPLFRFDDVYLGIVALKAGISLQHCDDFRFHRPAYKGPDSYSSVIASHEFGDPEEMTRVWNECRSANYA

Gene Information

Entrez Gene ID
31358
Gene Name
brainiac
Gene Symbol
brn
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005795 ISS:UniProtKB C Golgi stack
GO:0005576 ISS:FlyBase C extracellular region
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008375 TAS:FlyBase F acetylglucosaminyltransferase activity
GO:0046981 IDA:FlyBase F beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity
GO:0047915 IEA:UniProtKB-EC F ganglioside galactosyltransferase activity
GO:0007219 IEA:UniProtKB-KW P Notch signaling pathway
GO:0007298 IMP:FlyBase P border follicle cell migration
GO:0007293 IMP:FlyBase P germarium-derived egg chamber formation
GO:0006688 IDA:FlyBase P glycosphingolipid biosynthetic process
GO:0042248 IMP:FlyBase P maintenance of polarity of follicular epithelium
GO:0016333 IMP:FlyBase P morphogenesis of follicular epithelium
GO:0048477 NAS:FlyBase P oogenesis
GO:0001744 IMP:FlyBase P optic lobe placode formation
GO:0030707 IMP:FlyBase P ovarian follicle cell development
GO:0007299 IMP:FlyBase P ovarian follicle cell-cell adhesion
GO:0006486 IEA:InterPro P protein glycosylation

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
brainiac
Protein Entry
Q24157_DROME
UniProt ID
Q24157
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity UDP-alpha-D-galactose + an N-acetyl-beta-D- galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta- D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha- N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D- glucosyl-(1<->1)-ceramide.
Function Neurogenic protein essential for the development and maintenance of epithelial structure. Required in the germline for establishing the follicular epithelium and for determining the dorsal-ventral polarity. Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Brn has a role in chorion formation.
Sequence Caution Sequence=AAL48007.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the glycosyltransferase 31 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP008844 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17136782 RefSeq NP_476901 325 brainiac

Identical Sequences to LMP008844 proteins

Reference Database Accession Length Protein Name
GI:17136782 EMBL CAA21833.1 325 EG:EG0007.6 [Drosophila melanogaster]
GI:17136782 GenBank AAX33398.1 325 RE62856p [Drosophila melanogaster]
GI:17136782 gnl FlyBase 325 brainiac [Drosophila melanogaster]
GI:17136782 SwissProt Q24157.2 325 RecName: Full=Beta-1,3-galactosyltransferase brn; AltName: Full=Brainiac protein; AltName: Full=Neurogenic secreted-signaling protein brn [Drosophila melanogaster]

Related Sequences to LMP008844 proteins

Reference Database Accession Length Protein Name
GI:17136782 GenBank AAA85211.1 325 neurogenic secreted signaling protein [Drosophila melanogaster]
GI:17136782 GenBank AAE27292.1 325 Sequence 5 from patent US 5955282
GI:17136782 GenBank AAR77956.1 325 Sequence 5 from patent US 6649737
GI:17136782 GenBank EDW53206.1 325 GM12324 [Drosophila sechellia]
GI:17136782 GenBank EDX17037.1 325 GD16669 [Drosophila simulans]
GI:17136782 RefSeq XP_002037047.1 325 GM12324 [Drosophila sechellia]