Gene/Proteome Database (LMPD)

LMPD ID
LMP008855
Gene ID
41678
Species
Drosophila melanogaster (Drosophila)
Gene Name
neither inactivation nor afterpotential B
Gene Symbol
ninaB
Synonyms
anon-WO0148162.1; anon-WO0148163.1; beta-diox; CG9347; Dmel\CG9347; DRPE65; RPE65
Alternate Names
CG9347-PA; beta-carotene dioxygenase; neither inactivation nor afterpotential B; ninaB-PA
Chromosome
3R
Map Location
87F11-87F11
EC Number
1.13.11.65

Proteins

neither inactivation nor afterpotential B
Refseq ID NP_650307
Protein GI 24646669
UniProt ID Q9VFS2
mRNA ID NM_142050
Length 620
RefSeq Status REVIEWED
MAAGVFKSFMRDFFAVKYDEQRNDPQAERLDGNGRLYPNCSSDVWLRSCEREIVDPIEGHHSGHIPKWICGSLLRNGPGSWKVGDMTFGHLFDCSALLHRFAIRNGRVTYQNRFVDTETLRKNRSAQRIVVTEFGTAAVPDPCHSIFDRFAAIFRPDSGTDNSMISIYPFGDQYYTFTETPFMHRINPCTLATEARICTTDFVGVVNHTSHPHVLPSGTVYNLGTTMTRSGPAYTILSFPHGEQMFEDAHVVATLPCRWKLHPGYMHTFGLTDHYFVIVEQPLSVSLTEYIKAQLGGQNLSACLKWFEDRPTLFHLIDRVSGKLVQTYESEAFFYLHIINCFERDGHVVVDICSYRNPEMINCMYLEAIANMQTNPNYATLFRGRPLRFVLPLGTIPPASIAKRGLVKSFSLAGLSAPQVSRTMKHSVSQYADITYMPTNGKQATAGEESPKRDAKRGRYEEENLVNLVTMEGSQAEAFQGTNGIQLRPEMLCDWGCETPRIYYERYMGKNYRYFYAISSDVDAVNPGTLIKVDVWNKSCLTWCEENVYPSEPIFVPSPDPKSEDDGVILASMVLGGLNDRYVGLIVLCAKTMTELGRCDFHTNGPVPKCLHGWFAPNAI

Gene Information

Entrez Gene ID
41678
Gene Name
neither inactivation nor afterpotential B
Gene Symbol
ninaB
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0003834 IDA:FlyBase F beta-carotene 15,15'-monooxygenase activity
GO:0010436 IDA:FlyBase F carotenoid dioxygenase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004497 IEA:UniProtKB-KW F monooxygenase activity
GO:0004744 IDA:FlyBase F retinal isomerase activity
GO:0016119 IDA:FlyBase P carotene metabolic process
GO:0007602 TAS:FlyBase P phototransduction
GO:0042574 IDA:FlyBase P retinal metabolic process
GO:0042572 IEA:UniProtKB-UniPathway P retinol metabolic process
GO:0016063 IDA:FlyBase P rhodopsin biosynthetic process
GO:0035238 IDA:FlyBase P vitamin A biosynthetic process
GO:0009110 IMP:FlyBase P vitamin biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6225976 Diseases associated with visual transduction
6226810 Retinoid metabolism and transport
6226029 The canonical retinoid cycle in rods (twilight vision)
6225974 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR004294 Carotenoid oxygenase

UniProt Annotations

Entry Information

Gene Name
neither inactivation nor afterpotential B
Protein Entry
NINAB_DROME
UniProt ID
Q9VFS2
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Zeaxanthin + O(2) = (3R)-11-cis-3- hydroxyretinal + (3R)-all-trans-3-hydroxyretinal. {ECO:0000269|PubMed:10766819, ECO:0000269|PubMed:19889630}.
Cofactor Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250};
Function Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception. {ECO:0000269|PubMed:11158606, ECO:0000269|PubMed:14982930, ECO:0000269|PubMed:17344064, ECO:0000269|PubMed:17452532, ECO:0000269|PubMed:19889630}.
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the carotenoid oxygenase family. {ECO:0000305}.
Tissue Specificity Expression follows organogenesis of the larval Bolwig's organ (BO), which mediates larval photophobic behavior. In the adult, expression is restricted exclusively to the brain. Expressed in both neuronal cells and glia cells. Not active within photoreceptors. Active within neuronal cells within the central nervous system. {ECO:0000269|PubMed:10766819, ECO:0000269|PubMed:14982930, ECO:0000269|PubMed:17344064, ECO:0000269|PubMed:17452532, ECO:0000269|PubMed:19889630}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008855 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24646669 RefSeq NP_650307 620 neither inactivation nor afterpotential B

Identical Sequences to LMP008855 proteins

Reference Database Accession Length Protein Name
GI:24646669 EMBL CAC50772.1 620 unnamed protein product [Drosophila melanogaster]
GI:24646669 EMBL CAC50781.1 620 unnamed protein product [Drosophila melanogaster]
GI:24646669 GenBank AAM51944.1 620 GH03958p [Drosophila melanogaster]
GI:24646669 GenBank ACL85996.1 620 ninaB-PA, partial [synthetic construct]
GI:24646669 GenBank ACL90783.1 620 ninaB-PA [synthetic construct]
GI:24646669 SwissProt Q9VFS2.1 620 RecName: Full=Carotenoid isomerooxygenase; AltName: Full=Beta-carotene 15,15'-monooxygenase and retinoid isomerase; AltName: Full=Beta-carotene dioxygenase and retinoid isomerase; AltName: Full=Neither inactivation nor afterpotential mutant B [Drosophila melanogaster]

Related Sequences to LMP008855 proteins

Reference Database Accession Length Protein Name
GI:24646669 DBBJ BAA94508.1 620 DRPE65 [Drosophila melanogaster]
GI:24646669 GenBank EDW42280.1 620 GM24124 [Drosophila sechellia]
GI:24646669 GenBank EDX13039.1 620 GD18923 [Drosophila simulans]
GI:24646669 RefSeq XP_001980231.1 620 GG19789 [Drosophila erecta]
GI:24646669 RefSeq XP_002031294.1 620 GM24124 [Drosophila sechellia]
GI:24646669 RefSeq XP_002103536.1 620 GD18923 [Drosophila simulans]