Gene/Proteome Database (LMPD)

LMPD ID
LMP008859
Gene ID
40015
Species
Drosophila melanogaster (Drosophila)
Gene Name
reaper
Gene Symbol
rpr
Synonyms
anon-WO0162936.19; CG4319; Dmel\CG4319; rp; Rpr; RPR
Alternate Names
CG4319-PA; reaper; reaper L; rpr-PA
Chromosome
3L
Map Location
75C6-75C6

Proteins

reaper
Refseq ID NP_524138
Protein GI 17737621
UniProt ID Q24475
mRNA ID NM_079414
Length 65
RefSeq Status REVIEWED
MAVAFYIPDQATLLREAEQKEQQILRLRESQWRFLATVVLETLRQYTSCHPKTGRKSGKYRKPSQ

Gene Information

Entrez Gene ID
40015
Gene Name
reaper
Gene Symbol
rpr
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 TAS:FlyBase C cytoplasm
GO:0005741 IDA:FlyBase C mitochondrial outer membrane
GO:0005739 IDA:FlyBase C mitochondrion
GO:0005543 IDA:FlyBase F phospholipid binding
GO:0042803 IDA:FlyBase F protein homodimerization activity
GO:0031625 IPI:FlyBase F ubiquitin protein ligase binding
GO:0006915 IDA:FlyBase P apoptotic process
GO:0097190 IMP:FlyBase P apoptotic signaling pathway
GO:0008219 IMP:FlyBase P cell death
GO:0071480 IMP:FlyBase P cellular response to gamma radiation
GO:0035072 IEP:FlyBase P ecdysone-mediated induction of salivary gland cell autophagic cell death
GO:0048803 IMP:FlyBase P imaginal disc-derived male genitalia morphogenesis
GO:0008630 IMP:FlyBase P intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008627 TAS:FlyBase P intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0035193 TAS:FlyBase P larval central nervous system remodeling
GO:0035096 IGI:FlyBase P larval midgut cell programmed cell death
GO:0043524 IMP:FlyBase P negative regulation of neuron apoptotic process
GO:0031398 IDA:FlyBase P positive regulation of protein ubiquitination
GO:2000060 IGI:FlyBase P positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0012501 IMP:FlyBase P programmed cell death
GO:0042176 IDA:FlyBase P regulation of protein catabolic process
GO:0035071 IGI:FlyBase P salivary gland cell autophagic cell death

Domain Information

InterPro Annotations

Accession Description

UniProt Annotations

Entry Information

Gene Name
reaper
Protein Entry
RPR_DROME
UniProt ID
Q24475
Species
Drosophila

Comments

Comment Type Description
Developmental Stage Expression coincides with the onset of programmed cell death (PCD) at all stages of embryonic development. {ECO:0000269|PubMed:8171319}.
Function Activator of apoptosis, as well as grim and W, that acts on the effector, Dredd. {ECO:0000269|PubMed:8171319, ECO:0000269|PubMed:9740659}.
Interaction Q24306:th; NbExp=6; IntAct=EBI-106786, EBI-456419;
Miscellaneous Ectopic expression in the developing eye results in a small eye owing to excess cell death.

Identical and Related Proteins

Unique RefSeq proteins for LMP008859 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17737621 RefSeq NP_524138 65 reaper

Identical Sequences to LMP008859 proteins

Reference Database Accession Length Protein Name
GI:17737621 GenBank AAY55700.1 65 IP02530p [Drosophila melanogaster]
GI:17737621 GenBank ABJ28672.1 65 Sequence 1 from patent US 7094529
GI:17737621 GenBank ABK57070.1 65 IP02529p [Drosophila melanogaster]
GI:17737621 GenBank ACL88162.1 65 rpr-PA, partial [synthetic construct]
GI:17737621 GenBank ACO34941.1 65 raper [P element transformation vector pGX-attP]
GI:17737621 gnl FlyBase 65 reaper [Drosophila melanogaster]

Related Sequences to LMP008859 proteins

Reference Database Accession Length Protein Name
GI:17737621 GenBank AAN95597.1 63 Sequence 28 from patent US 6469144
GI:17737621 GenBank EDV51871.1 65 GG15745 [Drosophila erecta]
GI:17737621 GenBank EDX10950.1 65 GD12346 [Drosophila simulans]
GI:17737621 RefSeq XP_001972845.1 65 GG15745 [Drosophila erecta]
GI:17737621 RefSeq XP_002042576.1 65 GM14944 [Drosophila sechellia]
GI:17737621 RefSeq XP_002085365.1 65 GD12346 [Drosophila simulans]