Gene/Proteome Database (LMPD)

LMPD ID
LMP008862
Gene ID
42131
Species
Drosophila melanogaster (Drosophila)
Gene Name
Peroxinectin-like
Gene Symbol
Pxt
Synonyms
anon-WO0172774.128; CG7660; Dmel\CG7660; Dpxt; pxd; pxt
Chromosome
3R
Map Location
90C2-90C

Proteins

Peroxinectin-like
Refseq ID NP_650648
Protein GI 28571758
UniProt ID Q9VEG6
mRNA ID NM_142391
Length 809
RefSeq Status REVIEWED
MSRILFILLLLIVTQLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLKKCLPCSDGIRCVPQIQCPAHVRMESHEKPQICDLPAGKFGYCCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLSDVDRPHPKYNLMVMQFGQVLAHDISQTSSIRLEDGSLVQCCSPEGKVALSPQQSHFACMPIHVEPDDEFFSAFGVRCLNFVRLSLVPSPDCQLSYGKQLTKVTHFVDASPVYGSSDEASRSLRAFRGGRLRMMNDFGRDLLPLTNDKKACPSEEAGKSCFHSGDGRTNQIISLITLQILLAREHNRVAGALHELNPSASDETLFQEARRIVIAEMQHITYNEFLPIIIGPQQMKRFRLVPLHQGYSHDYNVNVNPAITNEFSGAAYRMGHSSVDGKFQIRQEHGRIDEVVNIPDVMFNPSRMRKREFYDDMLRTLYSQPMQQVDSSISQGLSRFLFRGDNPFGLDLAAINIQRGRDQGLRSYNDYLELMGAPKLHSFEQFPIEIAQKLSRVYRTPDDIDLWVGGLLEKAVEGGVVGVTFAEIIADQFARFKQGDRYYYEYDNGINPGAFNPLQLQEIRKVTLARLLCDNSDRLTLQAVPLAAFVRADHPGNQMIGCDDPNLPSVNLEAWRA

Gene Information

Entrez Gene ID
42131
Gene Name
Peroxinectin-like
Gene Symbol
Pxt
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:UniProtKB C extracellular space
GO:0005875 IDA:FlyBase C microtubule associated complex
GO:0020037 IEA:InterPro F heme binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004601 ISS:UniProtKB F peroxidase activity
GO:0004666 ISM:FlyBase F prostaglandin-endoperoxide synthase activity
GO:0007304 IMP:FlyBase P chorion-containing eggshell formation
GO:0007306 ISS:UniProtKB P eggshell chorion assembly
GO:0042744 IEA:UniProtKB-KW P hydrogen peroxide catabolic process
GO:0042743 ISS:UniProtKB P hydrogen peroxide metabolic process
GO:0030707 IMP:UniProtKB P ovarian follicle cell development
GO:0001516 IMP:FlyBase P prostaglandin biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR010255 Haem_peroxidase
IPR019791 Haem peroxidase, animal
IPR029590 Pxt

UniProt Annotations

Entry Information

Gene Name
Peroxinectin-like
Protein Entry
Q9VEG6_DROME
UniProt ID
Q9VEG6
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
Cofactor Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence= ; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per heterodimer. ;
Developmental Stage Expressed both maternally and zygotically.
Disruption Phenotype Females are sterile, and maturing follicles show defects in actin filament formation, nurse cell membrane stability and border cell migration.
Function Required for ovarian follicle maturation. Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization.
Sequence Caution Sequence=AAF78217.1; Type=Erroneous termination; Positions=810; Note=Translated as stop.; Evidence= ; Sequence=AAF78217.1; Type=Frameshift; Positions=220, 233, 238, 244, 331, 336, 381, 384, 644, 688; Evidence= ;
Similarity Belongs to the peroxidase family. XPO subfamily.
Subcellular Location Secreted . Note=In the chorion layer of the mature eggs.
Subunit Heterodimer.
Tissue Specificity Expressed at low levels in the germarium and early follicles. Expression becomes progressively stronger during vitellogenesis, and is highly expressed in germ cells and somatic cells. A subset of follicle cells, termed border cells (BC), exhibit a high level of expression.

Identical and Related Proteins

Unique RefSeq proteins for LMP008862 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28571758 RefSeq NP_650648 809 Peroxinectin-like

Identical Sequences to LMP008862 proteins

Reference Database Accession Length Protein Name
GI:28571758 GenBank AAM50270.1 809 LD43174p [Drosophila melanogaster]
GI:28571758 gnl FlyBase 809 Peroxinectin-like [Drosophila melanogaster]
GI:28571758 SwissProt Q9VEG6.3 809 RecName: Full=Chorion peroxidase; AltName: Full=Peroxinectin-related protein; Short=Dpxt; Flags: Precursor [Drosophila melanogaster]

Related Sequences to LMP008862 proteins

Reference Database Accession Length Protein Name
GI:28571758 GenBank EDV48685.1 809 GG22459 [Drosophila erecta]
GI:28571758 GenBank EDW44698.1 809 GM15259 [Drosophila sechellia]
GI:28571758 GenBank EDX12533.1 809 GD19183 [Drosophila simulans]
GI:28571758 RefSeq XP_001979727.1 809 GG22459 [Drosophila erecta]
GI:28571758 RefSeq XP_002041050.1 809 GM15259 [Drosophila sechellia]
GI:28571758 RefSeq XP_002103030.1 809 GD19183 [Drosophila simulans]