Gene/Proteome Database (LMPD)

LMPD ID
LMP008875
Gene ID
32858
Species
Drosophila melanogaster (Drosophila)
Gene Name
Cytochrome P450-18a1
Gene Symbol
Cyp18a1
Synonyms
181H6T; 18a1; CG6816; CT20826; cyp18; Cyp18; CYP18; cyp18a1; Cyp18A1; CYP18A1-Dm; Cyt-P450-17C; CytP450; Dmel\CG6816; Eig17-1; ESTS:181H6T; P-450; P450
Alternate Names
CG6816-PA; CG6816-PB; Cyp18a1-PA; Cyp18a1-PB; cytochrome P450 17C; cytochrome P450-18a1
Chromosome
X
Map Location
17D1-17D1
EC Number
1.14.-.-

Proteins

cytochrome P450-18a1, isoform A
Refseq ID NP_728191
Protein GI 24643092
UniProt ID Q95078
mRNA ID NM_167628
Length 538
RefSeq Status REVIEWED
Protein sequence is identical to GI:24643094 (mRNA isoform)
cytochrome P450-18a1, isoform B
Refseq ID NP_523403
Protein GI 24643094
UniProt ID Q95078
mRNA ID NM_078679
Length 538
RefSeq Status REVIEWED
MLADSYLIKFVLRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGSEKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREEFTGRPDTPFMQTLNGYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEIHTVDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGRHRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNGYTIPAGSHVIPLINSVHMDPNLWEKPEEFRPSRFIDTEGKVRKPEYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVGATITPESFKVCLKRRPLGPTAADPHHMRNVGAN

Gene Information

Entrez Gene ID
32858
Gene Name
Cytochrome P450-18a1
Gene Symbol
Cyp18a1
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008395 IDA:FlyBase F steroid hydroxylase activity
GO:0007304 IMP:FlyBase P chorion-containing eggshell formation
GO:0046344 IMP:FlyBase P ecdysteroid catabolic process
GO:0007480 IMP:FlyBase P imaginal disc-derived leg morphogenesis
GO:0007552 IMP:FlyBase P metamorphosis
GO:0035210 IMP:FlyBase P prepupal development
GO:0035074 IMP:FlyBase P pupation

KEGG Pathway Links

KEGG Pathway ID Description
dme00981 Insect hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6226226 Aflatoxin activation and detoxification
6226070 Methylation
6226956 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
Cytochrome P450-18a1
Protein Entry
CP18A_DROME
UniProt ID
Q95078
Species
Drosophila

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental Stage Low levels throughout postembryonic development.
Function Probably involved in steroid hormones biosynthesis. {ECO:0000269|PubMed:9256362}.
Induction By 20-hydroxyecdysone during the three larval stages, at pupariation and in pupae. {ECO:0000269|PubMed:9256362}.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in body wall (epidermal and muscle cells) and mid-and hind-gut. {ECO:0000269|PubMed:9256362}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008875 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24643094 RefSeq NP_523403 538 cytochrome P450-18a1, isoform B

Identical Sequences to LMP008875 proteins

Reference Database Accession Length Protein Name
GI:24643094 EMBL CAL69944.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]
GI:24643094 EMBL CAL69946.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]
GI:24643094 EMBL CAL69948.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]
GI:24643094 EMBL CAL69950.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]
GI:24643094 EMBL CAL69952.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]
GI:24643094 EMBL CAL69954.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]

Related Sequences to LMP008875 proteins

Reference Database Accession Length Protein Name
GI:24643094 EMBL CAL69940.1 538 cytochrome P450 Cyp18a1 [Drosophila melanogaster]
GI:24643094 GenBank AAB69750.1 538 cytochrome P450 [Drosophila melanogaster]
GI:24643094 GenBank EDW56057.1 538 GM22791 [Drosophila sechellia]
GI:24643094 GenBank EDX16681.1 538 GD24470 [Drosophila simulans]
GI:24643094 RefSeq XP_002039315.1 538 GM22791 [Drosophila sechellia]
GI:24643094 RefSeq XP_002077087.1 538 GD24470 [Drosophila simulans]