Gene/Proteome Database (LMPD)

LMPD ID
LMP008890
Gene ID
31849
Species
Drosophila melanogaster (Drosophila)
Gene Name
Oligosaccharyltransferase 48kD subunit
Gene Symbol
Ost48
Synonyms
anon-EST:Liang-1.11; CG9022; clone 1.11; Dmel\CG9022; DmOST50; DrOST; ost48; OST48; OST48/WBP1; Ots48
Alternate Names
CG9022-PA; Ost48-PA; oligosaccaryltransferase 48kDa subunit; oligosaccharyltransferase 48kD subunit
Chromosome
X
Map Location
8C14-8C14
EC Number
2.4.99.18

Proteins

oligosaccharyltransferase 48kD subunit
Refseq ID NP_511096
Protein GI 24640745
UniProt ID Q24319
mRNA ID NM_078541
Length 449
RefSeq Status REVIEWED
MMWKALLIAVLAIAHCQAVLETDANTLVLLDNLAIRETHSIFFKSLQDRGFKLTYKLADDSSLLLSKYGEYLYKNVIIFAPSVEEFGGDVSVERLAQFVDDGGNVLVAGSEKSGDALREFASECGFELDEENAAVIDHLHYDVSDAGEHTTILTSAKNLIQADTIVGKANRQADAAPLLYRGTGLIADKENPLVLKLLTAESTAYSYNPEASVSDYPHAVGRGTLLIAALQARNNARVVFSGSLLFFSDESFTTAVQYAQSGVFHKLAGNRDVAESISKWVFGETGRLRVASVQHHKEGELLPPDQAYTITDPVVYTIGIEELVQGEWRAFKASDIQLEFVRIDPFVRTYLKQTNTGAYQAKFKIPDVYGVYQFKVDYNRVGYTHLYSTTQVSVRPLEHTQYERFIPSAFPYYTSAFSMMIGVFVFSFVFLHFKDEPVGRAAKEDKKSQ

Gene Information

Entrez Gene ID
31849
Gene Name
Oligosaccharyltransferase 48kD subunit
Gene Symbol
Ost48
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IDA:FlyBase C lipid particle
GO:0004579 IEA:InterPro F dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0007030 IMP:FlyBase P Golgi organization
GO:0034389 IMP:FlyBase P lipid particle organization
GO:0022008 IMP:FlyBase P neurogenesis
GO:0018279 IEA:InterPro P protein N-linked glycosylation via asparagine

KEGG Pathway Links

KEGG Pathway ID Description
dme00510 N-Glycan biosynthesis
dme_M00072 N-glycosylation by oligosaccharyltransferase
dme04141 Protein processing in endoplasmic reticulum

REACTOME Pathway Links

REACTOME Pathway ID Description
6226917 SRP-dependent cotranslational protein targeting to membrane

Domain Information

InterPro Annotations

Accession Description
IPR005013 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

UniProt Annotations

Entry Information

Gene Name
Oligosaccharyltransferase 48kD subunit
Protein Entry
OST48_DROME
UniProt ID
Q24319
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Dolichyl diphosphooligosaccharide + [protein]- L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
Function Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the DDOST 48 kDa subunit family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Subunit Component of the oligosaccharyltransferase (OST) complex. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008890 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24640745 RefSeq NP_511096 449 oligosaccharyltransferase 48kD subunit

Identical Sequences to LMP008890 proteins

Reference Database Accession Length Protein Name
GI:24640745 GenBank AAQ22519.1 449 LD21941p [Drosophila melanogaster]
GI:24640745 GenBank ABL48157.1 449 Sequence 990 from patent US 7135558
GI:24640745 GenBank ACL88290.1 449 Ost48-PA, partial [synthetic construct]
GI:24640745 GenBank ACL92402.1 449 Ost48-PA [synthetic construct]
GI:24640745 gnl FlyBase 449 oligosaccharyltransferase 48kD subunit [Drosophila melanogaster]
GI:24640745 SwissProt Q24319.2 449 RecName: Full=Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Short=DDOST 48 kDa subunit; Short=Oligosaccharyl transferase 48 kDa subunit; AltName: Full=DmOST50; Short=DrOST; AltName: Full=OST5OP; Flags: Precursor [Drosophila melanogaster]

Related Sequences to LMP008890 proteins

Reference Database Accession Length Protein Name
GI:24640745 GenBank EDW51276.1 449 GM13675 [Drosophila sechellia]
GI:24640745 GenBank EDX02175.1 449 GE17411 [Drosophila yakuba]
GI:24640745 GenBank EDX17475.1 449 GD16081 [Drosophila simulans]
GI:24640745 RefSeq XP_002043988.1 449 GM13675 [Drosophila sechellia]
GI:24640745 RefSeq XP_002101067.1 449 GE17411 [Drosophila yakuba]
GI:24640745 RefSeq XP_002106521.1 449 GD16081 [Drosophila simulans]