Gene/Proteome Database (LMPD)

LMPD ID
LMP008928
Gene ID
32585
Species
Drosophila melanogaster (Drosophila)
Gene Name
easily shocked
Gene Symbol
eas
Synonyms
ala; CG3525; Dmel\CG3525; EP770; EtnK; PC80; RE10142; RH11
Alternate Names
CG3525-PA; CG3525-PB; CG3525-PC; CG3525-PF; CG3525-PG; CG3525-PH; CG3525-PI; CG3525-PJ; alpha lobes absent; alpha-lobe absent; eas-PA; eas-PB; eas-PC; eas-PF; eas-PG; eas-PH; eas-PI; eas-PJ; easily shocked; easily-shocked; ethanolamine kinase
Chromosome
X
Map Location
14B7-14B7
EC Number
2.7.1.82

Proteins

easily shocked, isoform A
Refseq ID NP_523364
Protein GI 24642424
UniProt ID P54352
mRNA ID NM_078640
Length 495
RefSeq Status REVIEWED
MGTETKSNSYTGQISTSGGNPKVMKDSLSLVRQTVNQQTLSLSQSNQVQNQLNSHSNSNSYPNPSGSENKNENEQNSRDIRAKPEDKSRKEAIVPFVPIFVEEADVIQGAKELLKVIRPTWDLSHVEFKSFTDGITNKLVGCFHKEISKLNDENGGSYLPIKTQGLSPVQSEDPVIIEKEDDDEFTDDRAADDGSPVQYSDNVVLVRIYGNKTDLLIDRKAETQNFLLLHTYGLAPSLYATFKNGLVYEYVPGTTLNTDSVLCPEIWPLVARRMAEMHRKVRKHGDSSATKPMPMIWKKTQSFLDLVPERFSDAEKHKRVKETFLPIGRLREEFNKLYEYLEALDSPIVFSHNDLLLGNVIYTQSLNTVNFIDYEYADYNFQAFDIGNHFAEMCGVDEVDYSRYPKREFQLQWLRVYLEEYLQRSNIQNDEVELLYVQVNQFALASHIFWTVWSLLQAEHSTIDFDYVGYAFLRYNEYLARKVEFLSLTAAKNNK
easily shocked, isoform B
Refseq ID NP_727942
Protein GI 24642426
UniProt ID P54352
mRNA ID NM_167490
Length 495
RefSeq Status REVIEWED
Protein sequence is identical to GI:24642424 (mRNA isoform)
easily shocked, isoform C
Refseq ID NP_727943
Protein GI 24642428
UniProt ID P54352
mRNA ID NM_167491
Length 495
RefSeq Status REVIEWED
Protein sequence is identical to GI:24642424 (mRNA isoform)
easily shocked, isoform F
Refseq ID NP_001245706
Protein GI 386764534
UniProt ID X2JFQ7
mRNA ID NM_001258777
Length 171
RefSeq Status REVIEWED
MGTETKSNSYTGQISTSGGNPKVMKDSLSLVRQTVNQQTLSLSQSNQVQNQLNSHSNSNSYPNPSGSENKNENEQNSRDIRAKPEDKSRKEAIVPFVPIFVEEADVIQGAKELLKVIRPTWDLSHVEFKIRVVPQIEDRYPAQNAMVMMTLVLPMASQTNWSDVFIRRSPN
easily shocked, isoform G
Refseq ID NP_001245707
Protein GI 386764536
UniProt ID P54352
mRNA ID NM_001258778
Length 150
RefSeq Status REVIEWED
MSTIRSKKNVRQTVNQQTLSLSQSNQVQNQLNSHSNSNSYPNPSGSENKNENEQNSRDIRAKPEDKSRKEAIVPFVPIFVEEADVIQGAKELLKVIRPTWDLSHVEFKIRVVPQIEDRYPAQNAMVMMTLVLPMASQTNWSDVFIRRSPN
easily shocked, isoform H
Refseq ID NP_788914
Protein GI 386764538
UniProt ID P54352
mRNA ID NM_176741
Length 495
RefSeq Status REVIEWED
Protein sequence is identical to GI:24642424 (mRNA isoform)
easily shocked, isoform I
Refseq ID NP_727941
Protein GI 665391773
UniProt ID P54352
mRNA ID NM_167489
Length 495
RefSeq Status REVIEWED
Protein sequence is identical to GI:24642424 (mRNA isoform)
easily shocked, isoform J
Refseq ID NP_001285319
Protein GI 665391775
UniProt ID X2JFQ7
mRNA ID NM_001298390
Length 171
RefSeq Status REVIEWED
Protein sequence is identical to GI:386764534 (mRNA isoform)

Gene Information

Entrez Gene ID
32585
Gene Name
easily shocked
Gene Symbol
eas
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004103 NAS:FlyBase F choline kinase activity
GO:0004305 IDA:FlyBase F ethanolamine kinase activity
GO:0006657 NAS:GOC P CDP-choline pathway
GO:0008306 TAS:FlyBase P associative learning
GO:0055059 IMP:FlyBase P asymmetric neuroblast division
GO:0007420 IMP:FlyBase P brain development
GO:0046959 TAS:FlyBase P habituation
GO:0007616 TAS:FlyBase P long-term memory
GO:0007638 IMP:FlyBase P mechanosensory behavior
GO:0016319 IMP:FlyBase P mushroom body development
GO:0006646 IEA:UniProtKB-UniPathway P phosphatidylethanolamine biosynthetic process
GO:0046337 IDA:FlyBase P phosphatidylethanolamine metabolic process
GO:0016310 NAS:FlyBase P phosphorylation
GO:0001666 IDA:FlyBase P response to hypoxia
GO:0009612 IMP:FlyBase P response to mechanical stimulus

KEGG Pathway Links

KEGG Pathway ID Description
dme00564 Glycerophospholipid metabolism
dme01100 Metabolic pathways
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE
dme_M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

Domain Information

InterPro Annotations

Accession Description
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
easily shocked
Protein Entry
EAS_DROME
UniProt ID
X2JFQ7
Species
Drosophila

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=E; IsoId=P54352-1; Sequence=Displayed; Name=A; Synonyms=B, C, H, I; IsoId=P54352-2; Sequence=VSP_001068; Name=G; IsoId=P54352-4; Sequence=VSP_053946, VSP_053947, VSP_053948; Note=No experimental confirmation available.; Name=F; IsoId=P54352-5; Sequence=VSP_053947, VSP_053948; Note=No experimental confirmation available.;
Catalytic Activity ATP + ethanolamine = ADP + O- phosphoethanolamine.
Disruption Phenotype Bang sensitive phenotype; induction of paralysis with electrical stimulation results in a brief seizure, followed by a failure of the muscles to respond to giant fiber stimulation. This is due to an excitability defect caused by altered membrane phospholipid composition. {ECO:0000269|PubMed:7923374}.
Function Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. {ECO:0000269|PubMed:7923374}.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. {ECO:0000269|PubMed:7923374}.
Sequence Caution Sequence=ABE73230.1; Type=Frameshift; Positions=152; Evidence={ECO:0000305}; Sequence=ABE73230.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=ACV91649.1; Type=Frameshift; Positions=152, 215; Evidence={ECO:0000305};
Similarity Belongs to the choline/ethanolamine kinase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP008928 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24642424 RefSeq NP_523364 495 easily shocked, isoform A
386764534 RefSeq NP_001245706 171 easily shocked, isoform F
386764536 RefSeq NP_001245707 150 easily shocked, isoform G

Identical Sequences to LMP008928 proteins

Reference Database Accession Length Protein Name
GI:386764534 GenBank ABL47935.1 171 Sequence 324 from patent US 7135558
GI:24642424 GenBank ABL47976.1 495 Sequence 447 from patent US 7135558
GI:386764534 gnl FlyBase 171 easily shocked, isoform F [Drosophila melanogaster]
GI:386764536 gnl FlyBase 150 easily shocked, isoform G [Drosophila melanogaster]
GI:24642424 gnl FlyBase 495 easily shocked, isoform H [Drosophila melanogaster]
GI:24642424 gnl FlyBase 495 easily shocked, isoform I [Drosophila melanogaster]
GI:386764534 gnl FlyBase 171 easily shocked, isoform J [Drosophila melanogaster]
GI:24642424 RefSeq NP_727943.1 495 easily shocked, isoform C [Drosophila melanogaster]
GI:24642424 RefSeq NP_788914.2 495 easily shocked, isoform H [Drosophila melanogaster]
GI:24642424 RefSeq NP_727941.2 495 easily shocked, isoform I [Drosophila melanogaster]
GI:386764534 RefSeq NP_001285319.1 171 easily shocked, isoform J [Drosophila melanogaster]

Related Sequences to LMP008928 proteins

Reference Database Accession Length Protein Name
GI:386764534 GenBank AAC37209.1 517 ethanolamine kinase [Drosophila melanogaster]
GI:24642424 GenBank AAC37209.1 517 ethanolamine kinase [Drosophila melanogaster]
GI:386764536 GenBank ABL47935.1 171 Sequence 324 from patent US 7135558
GI:24642424 GenBank EDV46898.1 496 GG17946 [Drosophila erecta]
GI:24642424 GenBank EDX16632.1 494 GD24830 [Drosophila simulans]
GI:386764534 GenBank EDX16632.1 494 GD24830 [Drosophila simulans]
GI:386764536 gnl FlyBase 171 easily shocked, isoform F [Drosophila melanogaster]
GI:386764534 gnl FlyBase 150 easily shocked, isoform G [Drosophila melanogaster]
GI:386764536 gnl FlyBase 171 easily shocked, isoform J [Drosophila melanogaster]
GI:24642424 RefSeq XP_001977971.1 496 GG17946 [Drosophila erecta]
GI:386764534 RefSeq XP_002077038.1 494 GD24830 [Drosophila simulans]
GI:24642424 RefSeq XP_002077038.1 494 GD24830 [Drosophila simulans]
GI:386764536 RefSeq NP_001245706.1 171 easily shocked, isoform F [Drosophila melanogaster]
GI:386764534 RefSeq NP_001245707.1 150 easily shocked, isoform G [Drosophila melanogaster]
GI:386764536 RefSeq NP_001285319.1 171 easily shocked, isoform J [Drosophila melanogaster]
GI:386764534 SwissProt P54352.2 518 RecName: Full=Ethanolamine kinase; Short=EK; AltName: Full=Protein easily shocked [Drosophila melanogaster]
GI:24642424 SwissProt P54352.2 518 RecName: Full=Ethanolamine kinase; Short=EK; AltName: Full=Protein easily shocked [Drosophila melanogaster]
GI:386764536 SwissProt P54352.2 518 RecName: Full=Ethanolamine kinase; Short=EK; AltName: Full=Protein easily shocked [Drosophila melanogaster]